Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Dehydrocostus Lactone Suppresses the Expression of iNOS Induced by TLR Agonists

  • Kim, Su Yeon (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Heo, Sunghye (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Kim, Seung Han (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Kwon, Minji (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Park, Sin-Aye (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Youn, Hyung-Sun (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University)
  • Received : 2019.07.04
  • Accepted : 2019.08.17
  • Published : 2019.09.30
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Abstract

Toll-like receptors (TLRs) are one of the families of pattern recognition receptors (PRR) to recognize pathogen-associated molecular patterns (PAMPs). PAMPs stimulate TLRs to initiate specific immunoactivity. The activation of TLRs signaling leads to the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of dehydrocostus lactone (DHL), which is a natural sesquiterpene lactone derived from various medicinal plants, iNOS expression induced by LPS (TLR4 agonist), MALP-2 (TLR2 and TLR6 agonist), or Poly[I:C] (TLR3 agonist) were examined. DHL suppressed the iNOS expression induced by LPS, MALP-2, or Poly[I:C]. DHL also inhibited nitrite production induced by LPS, MALP-2, or Poly[I:C]. These results suggest that DHL can modulate TLRs signaling pathways resulting in anti-inflammatory effect.

Keywords

References

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