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Prebiotics: An overview of current researches and industrial applications

프리바이오틱스 최신 연구 현황 및 제품 개발 동향

  • Hwang, Hye Won (Department of Bioindustrial Engineering, Yonsei University) ;
  • Lee, Dong-Woo (Department of Bioindustrial Engineering, Yonsei University)
  • 황혜원 (연세대학교 바이오산업공학협동과정) ;
  • 이동우 (연세대학교 바이오산업공학협동과정)
  • Received : 2019.08.16
  • Accepted : 2019.09.13
  • Published : 2019.09.30

Abstract

Prebiotics are defined as substrates that are selectively utilized by host microorganisms conferring various health benefits. Current prebiotic researches not only focus on non-digestible oligosaccharides, but also extend to polyphenols and peptides. However, the extended scope of prebiotic research pertains its original purposes: promotion of beneficial bacteria in host guts and production of valuable metabolites. Maintenance of optimal gut microflora plays a key role in host health care benefits including anti-cancer activity, immune response modulation, blood lipid level reduction, increased mineral absorption, and weight loss. With increasing probiotics markets, prebiotics have also received much attention in functional food markets. Hence, many global food companies tempt to develop new prebiotics applicable for preventing human diseases as well as modulating immune system. In this review, we discuss current status of prebiotics research, market progress, and future perspectives of prebiotics.

Keywords

References

  1. Alander M, Matto J, Kneifel W, Johansson M, Kogler B, Crittenden R, Mattila-Sandholm T, Saarela M. Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis BB-12 in the gastrointestinal tract. Int. Dairy J. 11: 817-825 (2001) https://doi.org/10.1016/S0958-6946(01)00100-5
  2. Alles MS, de Roos NM, Bakx JC, van de Lisdonk E, Zock PL, Hautvast JGAJ. Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. Am. J. Clin. Nutr. 69: 64-69 (1999) https://doi.org/10.1093/ajcn/69.1.64
  3. Anadon A, Martinez-Larranaga MR, Ares I, Martinez MA. Prebiotics: Safety and toxicity considerations. pp. 757-775. In: Nutraceuticals. Gupta RC (ed). Academic Press, Boston, MA, USA. (2016)
  4. Anandharaj M, Sivasankari B, Parveen Rani R. Effects of probiotics, prebiotics, and synbiotics on hypercholesterolemia: A review. Chin. J. Biol. 2014: 7 (2014)
  5. Bindels LB, Segura Munoz RR, Gomes-Neto JC, Mutemberezi V, Martinez I, Salazar N, Cody EA, Quintero-Villegas MI, Kittana H, de los Reyes-Gavilan CG, Schmaltz RJ, Muccioli GG, Walter J, Ramer-Tait AE. Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome 5: 12 (2017) https://doi.org/10.1186/s40168-017-0230-5
  6. Boets E, Gomand SV, Deroover L, Preston T, Vermeulen K, De Preter V, Hamer HM, Van den Mooter G, De Vuyst L, Courtin CM. Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: A stable isotope study. J. Physiol. 595: 541-555 (2017) https://doi.org/10.1113/JP272613
  7. Borges S, Barbosa J, Teixeira P. Gynecological health and probiotics. pp. 741-752. In: Probiotics, prebiotics, and synbiotics. Watson RR, Preedy VR (eds). Academic Press, Boston, MA, USA. (2016)
  8. Brownawell AM, Caers W, Gibson GR, Kendall CW, Lewis KD, Ringel Y, Slavin JL. Prebiotics and the health benefits of fiber: Current regulatory status, future research, and goals. J. Nutr. 142: 962-74 (2012) https://doi.org/10.3945/jn.112.158147
  9. Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, Burcelin R. Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55: 1484-90 (2006) https://doi.org/10.2337/db05-1360
  10. Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D, De Backer F, Neyrinck AM, Delzenne NM. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am. J. Clin. Nutr. 90: 1236-43 (2009) https://doi.org/10.3945/ajcn.2009.28095
  11. Chang OK, Seol KH, Jeong SG, Oh MH, Park BY, Perrin C, Ham JS. Casein hydrolysis by Bifidobacterium longum KACC 91563 and antioxidant activities of peptides derived therefrom. J. Dairy Sci. 96: 5544-5555 (2013) https://doi.org/10.3168/jds.2013-6687
  12. Chen Q, Ren Y, Lu J, Bartlett M, Chen L, Zhang Y, Guo X, Liu C. A novel prebiotic blend product prevents irritable bowel syndrome in mice by improving gut microbiota and modulating immune response. Nutrients 9: 1341 (2017) https://doi.org/10.3390/nu9121341
  13. Crittenden RG, Playne MJ. Production, properties and applications of food-grade oligosaccharides. Trends Food Sci. Tech. 7: 353-361 (1996) https://doi.org/10.1016/S0924-2244(96)10038-8
  14. de Aguilar-Nascimento JE. Probiotics and prebiotics: Role in surgery recuperation? pp. 171-179. In: Bioactive foods in promoting health. Watson RR, Preedy VR (eds). Academic Press, Boston, MA, USA. (2010)
  15. Del Valle EMM. Cyclodextrins and their uses: A review. Process Biochem. 39: 1033-1046 (2004) https://doi.org/10.1016/S0032-9592(03)00258-9
  16. Delzenne NM, Williams CM. Prebiotics and lipid metabolism. Curr. Opin. Lipidol. 13: 61-67 (2002) https://doi.org/10.1097/00041433-200202000-00009
  17. den Besten G, Lange K, Havinga R, van Dijk TH, Gerding A, van Eunen K, Muller M, Groen AK, Hooiveld GJ, Bakker BM. Gutderived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids. Am. J. Physiol. 305: G900-G910 (2013)
  18. Frost & Sullivan, Functional and luxury foods market analysis. (2015)
  19. Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat. Rev. Gastroenterol. Hepatol. 14: 491 (2017) https://doi.org/10.1038/nrgastro.2017.75
  20. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J. Nutr. 125: 1401-12 (1995) https://doi.org/10.1093/jn/125.6.1401
  21. Global Industry Analysts, Inc, Prebiotics-Market Analysis, Trends, and Forecasts. (2019)
  22. Goldin BR, Gorbach SL. The effect of milk and Lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr. 39: 756-761 (1984) https://doi.org/10.1093/ajcn/39.5.756
  23. Goulas AK, Cooper JM, Grandison AS, Rastall RA. Synthesis of isomaltooligosaccharides and oligodextrans in a recycle membrane bioreactor by the combined use of dextransucrase and dextranase. Biotechnol. Bioeng. 88: 778-87 (2004) https://doi.org/10.1002/bit.20257
  24. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. The role of butyrate on colonic function. Aliment. Pharmacol. Ther. 27: 104-119 (2008) https://doi.org/10.1111/j.1365-2036.2007.03562.x
  25. Harmsen HJM, Wildeboer-Veloo ACM, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J. Pediatr. Gastroenterol. Nutr. 30: 61-67 (2000) https://doi.org/10.1097/00005176-200001000-00019
  26. Hegazi RA, Seth A. The role of prebiotics in gastrointestinal and liver diseases. pp. 569-583. In: Bioactive food as dietary interventions for liver and gastrointestinal disease. Watson RR, Preedy VR (eds). Academic Press, San Diego, CA, USA. (2013)
  27. Henderson WE, King W, Shetty JK. In situ fructooligosaccharide production and sucrose reduction. WO2007/061918A3 (2008)
  28. Hervert-Hernandez D, Pintado C, Rotger R, Goni I. Stimulatory role of grape pomace polyphenols on Lactobacillus acidophilus growth. Int. J. Food Microbiol. 136: 119-122 (2009) https://doi.org/10.1016/j.ijfoodmicro.2009.09.016
  29. Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microbiol. 19: 349-59 (2011) https://doi.org/10.1016/j.tim.2011.05.006
  30. Hume MP, Nicolucci AC, Reimer RA. Prebiotic supplementation improves appetite control in children with overweight and obesity: A randomized controlled trial. Am. J. Clin. Nutr. 105: 790-799 (2017) https://doi.org/10.3945/ajcn.116.140947
  31. Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey G, Goh YJ, Hamaker B, Martens EC, Mills DA, Rastal RA, Vaughan E, Sanders ME. Prebiotics: Why definitions matter. Curr. Opin. Biotech. 37: 1-7 (2016) https://doi.org/10.1016/j.copbio.2015.09.001
  32. Iannitti T, Palmieri B. Therapeutical use of probiotic formulations in clinical practice. Clin. Nutr. 29: 701-725 (2010) https://doi.org/10.1016/j.clnu.2010.05.004
  33. Ito M, Deguchi Y, Miyamori A, Matsumoto K, Kikuchi H, Matsumoto K, Kobayashi Y, Yajima T, Kan T. Effects of administration of galactooligosaccharides on the human faecal microflora, stool weight and abdominal sensation. Microb. Ecol. Health Dis. 3: 285-292 (1990) https://doi.org/10.3109/08910609009140251
  34. Ito M, Kimura M, Deguchi Y, Miyamori-Watabe A, Yajima T, Kan T. Effects of transgalactosylated disaccharides on the human intestinal microflora and their metabolism. J. Nutr. Sci. Vitaminol. 39: 279-288 (1993) https://doi.org/10.3177/jnsv.39.279
  35. Ivakhnenko OS, Nyankovskyy SL. Effect of the specific infant formula mixture of oligosaccharides on local immunity and development of allergic and infectious disease in young children: Randomized study. Pediatr. Pol. 88: 398-404 (2013) https://doi.org/10.1016/j.pepo.2013.07.002
  36. Kelly G. Inulin-type prebiotics-a review: Part 1. Altern. Med. Rev. 13 (2008)
  37. Kim T, Heinrich V, Johann FG, Gerhardt C A modified ${\beta}$-fructofuranosidase for fructooligosaccharide production, US10167459B2 (2017)
  38. Lena D. L. KMJ-F, Francois A. A. H. Process for producing a fructooligosaccharide composition, EP2294093B1 (2017)
  39. Letexier D, Diraison F, Beylot M. Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. Am. J. Clin. Nutr. 77: 559-564 (2003) https://doi.org/10.1093/ajcn/77.3.559
  40. Liepke C, Adermann K, Raida M, Magert H, Forssmann WG, Zucht HD. Human milk provides peptides highly stimulating the growth of bifidobacteria. Eur. J. Biochem. 269: 712-718 (2002) https://doi.org/10.1046/j.0014-2956.2001.02712.x
  41. Lin YT, Vattem D, Labbe RG, Shetty K. Enhancement of antioxidant activity and inhibition of Helicobacter pylori by phenolic phytochemical-enriched alcoholic beverages. Process Biochem. 40: 2059-2065 (2005) https://doi.org/10.1016/j.procbio.2004.07.019
  42. Macfarlane GT, Macfarlane S. Fermentation in the human large intestine: Its physiologic consequences and the potential contribution of prebiotics. J. Clin. Gastroenterol. 45 Suppl: S120-7 (2011) https://doi.org/10.1097/MCG.0b013e31822fecfe
  43. Markowiak P, Slizewska K. The role of probiotics, prebiotics and synbiotics in animal nutrition. Gut Pathog. 10: 21 (2018) https://doi.org/10.1186/s13099-018-0250-0
  44. McCabe L, Britton RA, Parameswaran N. Prebiotic and probiotic regulation of bone health: Role of the intestine and its microbiome. Curr. Osteoporos. Rep. 13: 363-71 (2015) https://doi.org/10.1007/s11914-015-0292-x
  45. Meyer D, Blaauwhoed JP. Inulin. pp. 829-848. In: Handbook of Hydrocolloids. Woodhead Publishing, Sawston, UK. (2009)
  46. Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch. Dis. Child. 91: 814-9 (2006) https://doi.org/10.1136/adc.2006.098251
  47. Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Boehm G. Dosage-related bifidogenic effects of galacto-and fructooligosaccharides in formula-fed term infants. J. Pediatr. Gastroenterol. Nutr. 34: 291-295 (2002) https://doi.org/10.1097/00005176-200203000-00014
  48. Ooi LG, Liong MT. Cholesterol-lowering effects of probiotics and prebiotics: A review of in vivo and in vitro findings. Int. J. Mol. Sci. 11: 2499-522 (2010) https://doi.org/10.3390/ijms11062499
  49. Ott SJ, Musfeldt M, Wenderoth DF, Hampe J, Brant O, Folsch UR, Timmis KN, Schreiber S. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 53: 685-93 (2004) https://doi.org/10.1136/gut.2003.025403
  50. Ouwehand AC, Tiihonen K, Makivuokko H, Rautonen N. Synbiotics: Combining the benefits of pre-and probiotics. pp. 195-213. In: Functional Dairy Products. Saarela M (ed). Woodhead Publishing, Sawston, UK. (2007)
  51. Reddy BS, Sharma C, Simi B, Engle A, Laakso K, Puska P, Korpela R. Metabolic epidemiology of colon cancer: Effect of dietary fiber on fecal mutagens and bile acids in healthy subjects. Cancer Res. 47: 644-648 (1987)
  52. Remaud-Simeon M, Willemot RM, Sarcabal P, de Montalk GP, Monsan P. Glucansucrases: Molecular engineering and oligosaccharide synthesis. J. Mol. Catal. B Enzym 10: 117-128 (2000) https://doi.org/10.1016/S1381-1177(00)00119-3
  53. Rycroft CE, Jones MR, Gibson GR, Rastall RA. A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J. Appl. Microbiol. 91: 878-887 (2001) https://doi.org/10.1046/j.1365-2672.2001.01446.x
  54. Sako T, Matsumoto K, Tanaka R. Recent progress on research and applications of non-digestible galacto-oligosaccharides. Int. Dairy J. 9: 69-80 (1999) https://doi.org/10.1016/S0958-6946(99)00046-1
  55. Sanders ME, Lenoir-Wijnkoop I, Salminen S, Merenstein DJ, Gibson GR, Petschow BW, Nieuwdorp M, Tancredi DJ, Cifelli CJ, Jacques P, Pot B. Probiotics and prebiotics: Prospects for public health and nutritional recommendations. Ann. NY Acad. Sci. 1309: 19-29 (2014) https://doi.org/10.1111/nyas.12377
  56. Sangeetha PT, Ramesh MN, Prapulla SG. Recent trends in the microbial production, analysis and application of fructooligosaccharides. Trends Food Sci. Tech. 16: 442-457 (2005) https://doi.org/10.1016/j.tifs.2005.05.003
  57. Schley PD, Field CJ. The immune-enhancing effects of dietary fibres and prebiotics. Brit. J. Nutr. 87: S221-S230 (2002) https://doi.org/10.1079/BJN/2002541
  58. Shan B, Cai YZ, Brooks JD, Corke H. Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): Activity against foodborne pathogenic bacteria. J. Agric. Food Chem. 55: 5484-5490 (2007) https://doi.org/10.1021/jf070424d
  59. Silk DBA, Davis A, Vulevic J, Tzortzis G, Gibson GR. Clinical trial: The effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment. Pharmacol. Ther. 29: 508-518 (2009) https://doi.org/10.1111/j.1365-2036.2008.03911.x
  60. Staudacher HM, Whelan K. Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet. Proc. Nutr. Soc. 75: 306-18 (2016) https://doi.org/10.1017/S0029665116000021
  61. Steinert RE, Sadabad MS, Harmsen HJM, Weber P. The prebiotic concept and human health: A changing landscape with riboflavin as a novel prebiotic candidate? Eur. J. Clin. Nutr. 70: 1348 (2016) https://doi.org/10.1038/ejcn.2016.119
  62. Tanaka R, Takayama H, Morotomi M, Kuroshima T, Ueyama S, Matsumoto K, Kuroda A, Mutai M. Effects of administration of TOS and Bifidobacterium breve 4006 on the human fecal flora. Bifidobacteria Microflora 2: 17-24 (1983) https://doi.org/10.12938/bifidus1982.2.1_17
  63. Telessy IG. Nutraceuticals. pp. 409-421. In: The Role of Functional Food Security in Global Health. Singh RB, Watson RR, Takahashi T (eds). Academic Press, Boston, MA, USA. (2019)
  64. Thompson RS, Roller R, Mika A, Greenwood BN, Knight R, Chichlowski M, Berg BM, Fleshner M. Dietary prebiotics and bioactive milk fractions improve NREM sleep, enhance REM sleep rebound and attenuate the stress-induced decrease in diurnal temperature and gut microbial alpha diversity. Front. Behav. Neurosci. 10 (2017)
  65. Topping DL. Short-chain fatty acids produced by intestinal bacteria. Asia Pac. J. Clin. Nutr. 5: 15-9 (1996)
  66. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI. A core gut microbiome in obese and lean twins. Nature 457: 480-4 (2009) https://doi.org/10.1038/nature07540
  67. Van Dokkum W, Wezendonk B, Srikumar TS, Van den Heuvel E. Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur. J. Clin. Nutr. 53: 1 (1999) https://doi.org/10.1038/sj.ejcn.1600668
  68. Vandenplas Y, Greef ED, Veereman G. Prebiotics in infant formula. Gut Microbes 5: 681-687 (2014) https://doi.org/10.4161/19490976.2014.972237
  69. Villamiel M, Corzo N, Foda MI, Montes F, Olano A. Lactulose formation catalysed by alkaline-substituted sepiolites in milk permeate. Food Chem. 76: 7-11 (2002) https://doi.org/10.1016/S0308-8146(01)00239-4
  70. Voragen AGJ. Technological aspects of functional food-related carbohydrates. Trends Food Sci. Tech. 9: 328-335 (1998) https://doi.org/10.1016/S0924-2244(98)00059-4
  71. Wang YB. Prebiotics: Present and future in food science and technology. Food Res. Int. 42: 8-12 (2009) https://doi.org/10.1016/j.foodres.2008.09.001
  72. Wollowski I, Rechkemmer G, Pool-Zobel BL. Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr 73: 451S-455S (2001) https://doi.org/10.1093/ajcn/73.2.451s
  73. Xu ZR, Hu CH, Xia MS, Zhan XA, Wang MQ. Effects of dietary fructooligosaccharide on digestive enzyme activities, intestinal microflora and morphology of male broilers. Poult. Sci. 82: 1030-1036 (2003) https://doi.org/10.1093/ps/82.6.1030
  74. Yoo JY, Kim SS. Probiotics and prebiotics: Present status and future perspectives on metabolic disorders. Nutrients 8: 173 (2016) https://doi.org/10.3390/nu8030173
  75. Zhou F, Jiang X, Wang T, Zhang B, Zhao H. Lycium barbarum polysaccharide (LBP): A novel prebiotics candidate for Bifidobacterium and Lactobacillus. Front. Microbiol. 9: 1034 (2018) https://doi.org/10.3389/fmicb.2018.01034
  76. 농림축산식품부. 장기능과 면역 증진을 위한 식품소재 개발 및 제품화 최종 보고서. 고부가가치식품기술개발사업 R&D Report (2017)
  77. 莉娜. 德利恩希尔约马基弗, 阿方斯.艾丽斯. 弗朗索瓦. 埃鲁福斯 Fructooligosaccharide composition, process for its production and use, US20110081449A1 (2014)
  78. 한국식품연구원. 자당활성효소를 활용한 신규 전분질 프리바이오틱스 소재 개발. (2018)