식품과학과 산업 (Food Science and Industry)

한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지
DOI QR코드

DOI QR Code

프로바이오틱스, 프리바이오틱스 및 신바이오틱스 연구동향

Trends in studies on probiotics, prebiotics, and synbiotics

  • 문기성 (한국교통대학교 생명공학전공)
  • Moon, Gi-Seong (Department of Biotechnology, Korea National University of Transportation)
  • 투고 : 2019.08.11
  • 심사 : 2019.09.09
  • 발행 : 2019.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Probiotics are very closely related to gut microbiome and recognized as beneficial microorganisms for our health. They have various biological effects such as inhibition of pathogenic bacteria, activation of beneficial bacteria, prevention of diarrhea and constipation, enhanced immune activity etc. Prebiotics, non-digestible carbohydrates such as galactooligosaccharide and fructooligosaccharide, are utilized by beneficial gut bacteria such as bifidobacteria and lactobacilli, resulting in production of short chain fatty acids which inhibit pathogenic bacteria in the gut and function for human health. Synbiotics are introduced for synergistic effects when probiotics are combined with prebiotics and now commercially available. At the moment many functional ingredients are developed and commercialized. Probiotics, prebiotics, and synbiotics might be hot items in the functional food market and the values will increase according to the results of human gut microbiome researches. To meet the situation, systematic and scientific studies as well as marketing effects should be accompanied.

키워드

참고문헌

  1. Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst. Rev. CD003048 (2010)
  2. Al-Sheraji SH, Ismail A, Manap MY, Mustafa S, Yusof RM, Hassan FA. Prebiotics as functional foods: A review. J. Funct. Foods 5: 1542-1553 (2013) https://doi.org/10.1016/j.jff.2013.08.009
  3. Anandharaj M, Sivasankari B, Rani RP. Effects of probiotics, prebiotics, and synbiotics on hypercholesterolemia: a review. Chin. J. Biol. Article ID 572754 (2014)
  4. Bielecka M, Biedrzycka E, Majkowska A, Juskiewicz J, Wroblewska M. Effect of non-digestible oligosaccharides on gut microecosystem in rats. Food Res. Int. 35: 139-144 (2002) https://doi.org/10.1016/S0963-9969(01)00175-2
  5. Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J. Gastroenterol. 44: 26-46 (2009) https://doi.org/10.1007/s00535-008-2296-0
  6. Brennan C, Samyue E. Evaluation of starch degradation and textural characteristics of dietary fiber enriched biscuits. Int. J. Food Prop. 7: 647-657 (2004) https://doi.org/10.1081/JFP-200033070
  7. Butel MJ. Probiotics, gut microbiota and health. Med. Mal. Infect. 44: 1-8 (2014) https://doi.org/10.1016/j.medmal.2013.10.002
  8. Chen XY, Ganzle MG. Lactose and lactose-derived oligosaccharides: More than prebiotics? Int. Dairy J. 67: 61-72 (2017) https://doi.org/10.1016/j.idairyj.2016.10.001
  9. Chonan O, Takahashi R, Watanuki M. Role and activity of gastrointestinal microflora in absorption of calcium and magnesium in rats fed ${\beta}$1-4 linked galactooligosaccharides. Biosci. Biotechnol. Biochem. 65: 1872-1875 (2001) https://doi.org/10.1271/bbb.65.1872
  10. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13: 701-712 (2012) https://doi.org/10.1038/nrn3346
  11. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am. J. Clin. Nutr. 73: 415S-420S (2001) https://doi.org/10.1093/ajcn/73.2.415s
  12. Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, Berenjian A, Ghasemi Y. Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Foods 8: 92 (2019) https://doi.org/10.3390/foods8030092
  13. Davis LMG, Martinez I, Walter J, Goin C, Hutkins RW. Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLos One 6: e25200 (2011) https://doi.org/10.1371/journal.pone.0025200
  14. den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J. Lipid Res. 54: 2325-2340 (2013) https://doi.org/10.1194/jlr.R036012
  15. Desai A, Powell I, Shah N. Survival and activity of probiotic lactobacilli in skim milk containing prebiotics. J. Food Sci. 69: FMS57-FMS60 (2004) https://doi.org/10.1111/j.1365-2621.2004.tb13371.x
  16. De Vrese M, Schrezenmeir J. Probiotics, prebiotics and synbiotics. pp. 1-66. In: Food Biotechnology, Advances in Biochemical Engineering/Biotechnology Stahl U, Donalies UEB, Nevoigt E (eds.). Springer, Berlin, Germany (2008)
  17. Farid R, Ahanchian H, Jabbari F, Moghiman T. Effect of a new synbiotic mixture on atopic dermatitis in children: A randomizedcontrolled trial. Iran. J. Pediatr. 21: 225-230 (2011)
  18. Farmer AD, Randall HA, Aziz Q. It's a gut feeling: how the gut microbiota affects the state of mind. J. Physiol. 592: 2981-2988 (2014) https://doi.org/10.1113/jphysiol.2013.270389
  19. Figueroa-Gonzalez I, Quijano G, Ramirez G, Cruz-Guerrero A. Probiotics and prebiotics-perspectives and challenges. J. Sci. Food Agric. 91: 1341-1348 (2011) https://doi.org/10.1002/jsfa.4367
  20. Foligne B, Daniel C, Pot B. Probiotics from research to market: the possibilities, risks and challenges. Curr. Opin. Microbiol. 16: 284-292 (2013) https://doi.org/10.1016/j.mib.2013.06.008
  21. Gasbarrini G, Bonvicini F, Gramenzi A. Probiotics history. J. Clin. Gastroenterol. 50: S116-S119 (2016) https://doi.org/10.1097/MCG.0000000000000697
  22. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 125: 1401-1412 (1995) https://doi.org/10.1093/jn/125.6.1401
  23. Gibson GR, Scott KP, Rastall RA, Tuohy KM, Hotchkiss A, Dubert-Ferrandon A, Gareau M, Murphy EF, Saulnier D, Loh G, Macfarlane S, Delzenne N, Ringel Y, Kozianowski G, Dickmann R, Lenoir-Wijnkoop I, Walker C, Buddington R. Dietary prebiotics: current status and new definition. Food Sci. Technol. Bull.: Func. Foods 7: 1-19 (2010) https://doi.org/10.1616/1476-2137.15880
  24. Gourbeyre P, Denery S, Bodinier M. Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions. J. Leukoc. Biol. 89: 685-95 (2011) https://doi.org/10.1189/jlb.1109753
  25. Hoveyda N, Heneghan C, Mahtani KR, Perera R, Roberts N, Glasziou P. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol. 9: 15 (2009) https://doi.org/10.1186/1471-230X-9-15
  26. Howard M, Kerley M, Mann F, Sunvold G, Reinhart G. Blood flow and epithelial cell proliferation of the canine colon are altered by source of dietary fiber. Vet. Clin. Nutr. 6: 8-15 (1999)
  27. Irvine SL, Hekmat S. Evaluation of sensory properties of probiotic yogurt containing food products with prebiotic fibres in Mwanza, Tanzania. Food Nutr. Sci. 2: 434-439 (2011) https://doi.org/10.4236/fns.2011.25061
  28. Islam SU. Clinical uses of probiotics. Medicine (Baltimore) 95: e2658 (2016) https://doi.org/10.1097/MD.0000000000002658
  29. Ito M, Deguchi Y, Miyamori A, Matsumoto K, Kikuchi H, Matsumoto K, Kobayashi Y, Yajima T, Kan T. Effects of administration of galactooligosaccharide on the human feacal microflora, stool weight and abdominal sensation. Microb. Ecol. Health Dis. 3: 285-292 (1990) https://doi.org/10.3109/08910609009140251
  30. Kang DW, Park JG, Ilhan ZE, Wallstrom G, Labaer J, Adams JB, Krajmalnik-Brown R. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLos One 8: e68322 (2013) https://doi.org/10.1371/journal.pone.0068322
  31. Karetkin BA, Guseva EV, Evdokimova SA, Mishchenko AS, Khabibulina NV, Grosheva VD, Menshutina NV, Panfilov VI. A quantitative model of Bacillus cereus ATCC 9634 growth inhibition by bifidobacteria for synbiotic effect evaluation. World J. Microbiol. Biotechnol. 35: 89 (2019) https://doi.org/10.1007/s11274-019-2665-2
  32. Karlsson, KA. Animal glycosphingolipids as membrane attachment sites for bacteria. Annu. Rev. Biochem. 58: 309-350 (1989) https://doi.org/10.1146/annurev.bi.58.070189.001521
  33. Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D, Gyftopoulou K, Skarmoutsou N, Fakiri EM. Health benefits of probiotics: a review. ISRN Nutr. 2013: 481651 (2013) https://doi.org/10.5402/2013/481651
  34. Kerry RG, Patra JK, Gouda S, Park Y, Shin HS, Das G. Benefaction of probiotics for human health: A review. J. Food Drug Anal. 26: 927-939 (2018) https://doi.org/10.1016/j.jfda.2018.01.002
  35. Kolida S, Gibson GR. Synbiotics in health and disease. Annu. Rev. Food Sci. Technol. 2: 373-393 (2011) https://doi.org/10.1146/annurev-food-022510-133739
  36. Krumbeck JA, Maldonado-Gomez MX, Martinez I, Frese SA, Burkey TE, Rasineni K, Ramer-Tait AE, Harris EN, Hutkins RW, Walter J. In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications. Appl. Environ. Microbiol. 81: 2455-2465 (2015) https://doi.org/10.1128/AEM.03903-14
  37. Krumbeck JA, Walter J, Hutkins RW. Synbiotics for improved human health: Recent developments, challenges, and opportunities. Annu. Rev. Food Sci. Technol. 9: 451-479 (2018) https://doi.org/10.1146/annurev-food-030117-012757
  38. Levkovich T, Poutahidis T, Smillie C, Varian BJ, Ibrahim YM, Lakritz JR, Alm EJ, Erdman SE. Probiotic bacteria induce a ‘glow of health’. PLos One 8: e53867 (2013) https://doi.org/10.1371/journal.pone.0053867
  39. Lew LC, Liong MT. Bioactives from probiotics for dermal health: functions and benefits. J. Appl. Microbiol. 114: 1241-1253 (2013) https://doi.org/10.1111/jam.12137
  40. Meijer BJ, Dieleman LA. Probiotics in the treatment of human inflammatory bowel diseases: update 2011. J. Clin. Gastroenterol. 45(Suppl.): S139-144 (2011) https://doi.org/10.1097/MCG.0b013e31822103f7
  41. Menard O, Butel MJ, Gaboriau-Routhiau V, Waligora-Dupriet AJ. Gnotobiotic mouse immune response induced by Bifidobacterium sp. strains isolated from infants. Appl. Environ. Microbiol. 74: 660-666 (2008) https://doi.org/10.1128/AEM.01261-07
  42. Miller LE, Ouwehand AC, Ibarra A. Effects of probiotic-containing products on stool frequency and intestinal transit in constipated adults: systematic review and meta-analysis of randomized controlled trials. Ann. Gastroenterol. 30: 629-639 (2017)
  43. Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EM. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut 59: 325-332 (2010) https://doi.org/10.1136/gut.2008.167270
  44. Moroti C, Souza Magri LF, Rezende-Costa M, Cavallini D, Sivieri K. Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus. Lipids Health Dis. 11: 29 (2012) https://doi.org/10.1186/1476-511X-11-29
  45. Mussatto SI, Mancilha IM. Non-digestible oligosaccharides: A review. Carbohydr. Polym. 68: 587-597 (2007) https://doi.org/10.1016/j.carbpol.2006.12.011
  46. Okada H, Kuhn C, Feillet H, Bach JF. The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Clin. Exp. Immunol. 160: 1-9 (2010)
  47. O'Toole PW, Marchesi JR, Hill C. Next-generation probiotics: the spectrum from probiotics to live biotherapeutics. Nat. Microbiol. 2: 17057 (2017) https://doi.org/10.1038/nmicrobiol.2017.57
  48. Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, Klinder A, O'Riordan M, O'Sullivan GC, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins JK. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am. J. Clin. Nutr. 85: 488-496 (2007) https://doi.org/10.1093/ajcn/85.2.488
  49. Rastall B, Gibson G. Prebiotics: Development and application. John Wiley & Sons Ltd., West Sussex, England (2006)
  50. Rastogi P, Saini H, Dixit J, Singhal R. Probiotics and oral health. Natl. J. Maxillofac. Surg. 2: 6-9 (2011) https://doi.org/10.4103/0975-5950.85845
  51. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol. 9: 313-323 (2009) https://doi.org/10.1038/nri2515
  52. Saarela M, Mogensen G, Fonden R, MattoJ, Mattila-Sandholm T. Probiotic bacteria: safety, functional and technological properties. J. Biotechnol. 84: 197-215 (2000) https://doi.org/10.1016/S0168-1656(00)00375-8
  53. Sabater C, Prodanov M, Olano A, Corzo N, Montilla A. Quantification of prebiotics in commercial infant formulas. Food Chem. 194: 6-11 (2016). https://doi.org/10.1016/j.foodchem.2015.07.127
  54. Salari P, Nikfar S, Abdollahi M. A meta-analysis and systematic review on the effect of probiotics in acute diarrhea. Inflamm. Allergy Drug Targets 11: 3-14 (2012) https://doi.org/10.2174/187152812798889394
  55. Salonen A, De Vos WM, Palva A. Gastro-intestinal microbiota in irritable bowel syndrome: present state and perspectives. Microbiology 156: 3205-3215 (2010) https://doi.org/10.1099/mic.0.043257-0
  56. Sanchez M, Darimont C, Drapeau V, Emady-Azar S, Lepage M, Rezzonico E, Ngom-Bru C, Berger B, Philippe L, Ammon-Zuffrey C, Leone P, Chevrier G, St-Amand E, Marette A, Dore J, Tremblay A. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Br. J. Nutr. 111: 1507-1519 (2014) https://doi.org/10.1017/S0007114513003875
  57. Sanders ME. Probiotics: definition, sources, selection, and uses. Clin. Infect. Dis. 46 Suppl 2: S58-61 (2008) https://doi.org/10.1086/523341
  58. Sangwan V, Tomar S, Singh R, Singh A, Ali B. Galactooligosaccharides: novel components of designer foods. J. Food Sci. 76: R103-R111 (2011) https://doi.org/10.1111/j.1750-3841.2011.02131.x
  59. Saulnier DMA. Synbiotics: making the most of probiotics by their combinations? pp. 9-19. In: Food science and technology bulletin: Functional foods vol. 4. Gibson GR (ed). IFIS Publishing, Reading, UK (2008)
  60. Scavuzzi BM, Henrique FC, Miglioranza LHS, Simao ANC, Dichi I. Impact of prebiotics, probiotics and synbiotics on components of the metabolic syndrome. Ann. Nutr. Disord. Ther. 1: 1009 (2014)
  61. Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E, Haapaniemi E, Kaakkola S, Eerola-Rautio J, Pohja M, Kinnunen E, Murros K, Auvinen P. Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov. Disord. 30: 350-358 (2015) https://doi.org/10.1002/mds.26069
  62. Scholtens PA, Alliet P, Raes M, Alles MS, Kroes H, Boehm G, Knippels LM, Knol J, Vandenplas Y. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructooligosaccharides. J. Nutr. 138: 1141-1147 (2008) https://doi.org/10.1093/jn/138.6.1141
  63. Schrezenmeir J, de Vrese M. Probiotics, prebiotics, and synbiotics-approaching a definition. Am. J. Clin. Nutr. 73(Suppl 2): 361S-364S (2001) https://doi.org/10.1093/ajcn/73.2.361s
  64. Sha S, Xu B, Wang X, Zhang Y, Wang H, Kong X, Zhu H, Wu K. The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease. Diagn. Microbiol. Infect. Dis. 75: 245-51 (2013) https://doi.org/10.1016/j.diagmicrobio.2012.11.022
  65. Shukla S, Shukla A, Mehboob S, Guha S. Meta-analysis: the effects of gut flora modulation using prebiotics, probiotics and synbiotics on minimal hepatic encephalopathy. Aliment. Pharmacol. Ther. 33: 662-671 (2011) https://doi.org/10.1111/j.1365-2036.2010.04574.x
  66. Singla V, Chakkaravarthi S. Applications of prebiotics in food industry: A review. Food Sci. Technol. Int. 23: 649-667 (2017) https://doi.org/10.1177/1082013217721769
  67. Sonnenburg ED, Zheng H, Joglekar P, Higginbottom SK, Firbank SJ, Bolam DN, Sonnenburg JL. Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations. Cell 141: 1241-1252 (2010) https://doi.org/10.1016/j.cell.2010.05.005
  68. Syngai GG, Gopi R, Bharali R, Dey S, Lakshmanan GM, Ahmed G. Probiotics-the versatile functional food ingredients. J. Food Sci. Technol. 53: 921-933 (2016) https://doi.org/10.1007/s13197-015-2011-0
  69. van den Nieuwboer M, van de Burgwal LHM, Claassen E. A quantitative key-opinion-leader analysis of innovation barriers in probiotic research and development: Valorisation and improving the tech transfer cycle. Pharma Nutr. 4: 9-18 (2016)
  70. van der Aa LB, Heymans HS, van Aalderen WM, Sprikkelman AB. Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. Pediatr. Allergy Immunol. 21: e355-e367 (2010) https://doi.org/10.1111/j.1399-3038.2009.00915.x
  71. Ventura M, O'Flaherty S, Claesson MJ, Turroni F, Klaenhammer TR, van Sinderen D, O'Toole PW. Genome-scale analyses of healthpromoting bacteria: probiogenomics. Nat. Rev. Microbiol. 7: 61-71 (2009) https://doi.org/10.1038/nrmicro2047
  72. Waligora-Dupriet AJ, Butel MJ. Microbiota and allergy: from dysbiosis to probiotics. pp. 413-434. In: Allergic diseases-highlights in the clinic, mechanisms and treatment. Pereira C (ed). InTech Europe, Rijeka, Croatia (2012)
  73. Wang H, Lee IS, Braun C, Enck P. Effect of probiotics on central nervous system functions in animals and humans: A systematic review. J. Neurogastroenterol. Motil. 22: 589-605 (2016) https://doi.org/10.5056/jnm16018