Korean Journal of Radiology

  • 제20권12호
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  • Pages.1616-1626
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  • 2019
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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DOI QR코드

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Intraindividual Comparison between Gadoxetate-Enhanced Magnetic Resonance Imaging and Dynamic Computed Tomography for Characterizing Focal Hepatic Lesions: A Multicenter, Multireader Study

  • An, Chansik (Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Chang Hee (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Byun, Jae Ho (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Lee, Min Hee (Department of Radiology, Soonchunhyang University Bucheon Hospital) ;
  • Jeong, Woo Kyoung (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, Sang Hyun (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Do Young (Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine) ;
  • Lim, Young-Suk (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Young Seok (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Kim, Ji Hoon (Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Choi, Moon Seok (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Myeong-Jin (Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine)
  • 투고 : 2019.05.29
  • 심사 : 2019.08.15
  • 발행 : 2019.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To compare the diagnostic accuracy of dynamic computed tomography (CT) and gadoxetate-enhanced magnetic resonance imaging (MRI) for characterization of hepatic lesions by using the Liver Imaging Reporting and Data System (LI-RADS) in a multicenter, off-site evaluation. Materials and Methods: In this retrospective multicenter study, we evaluated 231 hepatic lesions (114 hepatocellular carcinomas [HCCs], 58 non-HCC malignancies, and 59 benign lesions) confirmed histologically in 217 patients with chronic liver disease who underwent both gadoxetate-enhanced MRI and dynamic CT at one of five tertiary hospitals. Four radiologists at different institutes independently reviewed all MR images first and the CT images 4 weeks later. They evaluated the major and ancillary imaging features and categorized each hepatic lesion according to the LI-RADS v2014. Diagnostic performance was calculated and compared using generalized estimating equations. Results: MRI showed higher sensitivity and accuracy than CT for diagnosing hepatic malignancies; the pooled sensitivities, specificities, and accuracies for categorizing LR-5/5V/M were 59.0% vs. 72.4% (CT vs. MRI; p < 0.001), 83.5% vs. 83.9% (p = 0.906), and 65.3% vs. 75.3% (p < 0.001), respectively. CT and MRI showed comparable capabilities for differentiating between HCC and other malignancies, with pooled accuracies of 79.9% and 82.4% for categorizing LR-M, respectively (p = 0.139). Conclusion: Gadoxetate-enhanced MRI showed superior accuracy for categorizing LR-5/5V/M in hepatic malignancies in comparison with dynamic CT. Both modalities had comparable accuracies for distinguishing other malignancies from HCC.

키워드

과제정보

The authors would like to thank Sungwon Kim, MD, Jun Tae Kim, and Kyunghwa Han, PhD, from the Department of Radiology, Yonsei University College of Medicine, for their assistance in data collection and preparation (S.K. and J.K.) and statistical analysis (K.H.).

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