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Intraventricular Vancomycin Therapy for Intractable Bacillus cereus Ventriculitis

  • Hahn, Jong Woo (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Ju, Hee young (Center for Pediatric Cancer, National Cancer Center) ;
  • Park, Meerim (Center for Pediatric Cancer, National Cancer Center) ;
  • Yi, Eun Sang (Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Park, Byung-Kiu (Center for Pediatric Cancer, National Cancer Center) ;
  • Shin, Sang-Hoon (Neuro-Oncology Clinic, National Cancer Center) ;
  • Lee, Sang-Hyun (Department of Radiology, National Cancer Center) ;
  • Park, Hyeon Jin (Center for Pediatric Cancer, National Cancer Center) ;
  • Kang, Ji-Man (Center for Pediatric Cancer, National Cancer Center)
  • Received : 2018.11.26
  • Accepted : 2019.05.27
  • Published : 2019.08.25

Abstract

Bacillus cereus causes serious central nervous system infections, especially in immunocompromised patients. Successful treatment requires adequate antimicrobial concentrations in the cerebrospinal fluid; however, in some cases, achieving this with systemic treatment alone is difficult. We treated intractable B. cereus ventriculitis with intraventricular vancomycin, with no major adverse events.

의료관련 뇌실염/수막염(Healthcare-associated ventriculitis and meningitis)은 지역사회 수막염과 다른 역학적 특성과 병리 기전을 가진다. 일부에서는 전신 항생제투여 방법만으로 치료 반응이 불충분할 수 있으며, 이러한 경우 뇌실내로 적절한 항생제를 직접 주입하는 치료를 시도해 볼 수 있다. 본 저자들은 기존의 전신 항생제치료에 불응하는 Bacillus cereus에 의한 의료관련 뇌실염/수막염 환자를 뇌실내 반코마이신 주입요법으로 주요 부작용없이 성공적으로 치료하여 이를 보고하는 바이다.

Keywords

References

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