Comparison of Fornix and Stria Terminalis Connectivity among First-Episode Schizophrenia, Chronic Schizophrenia and Healthy Controls

초발 조현병, 만성 조현병과 건강 대조군의 뇌활과 분계섬유줄 연결성 비교

  • Lee, Arira (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Yun, Mirim (Department of Psychiatry, Hanyang University College of Medicine) ;
  • Yook, Ki Hwan (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Choi, Tai Kiu (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Lee, Kang Soo (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Bang, Minji (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Lee, Sang-Hyuk (Department of Psychiatry, CHA Bundang Medical Center, CHA University)
  • 이아리라 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 윤미림 (한양대학교 의과대학 정신건강의학교실) ;
  • 육기환 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 최태규 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 이강수 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 방민지 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 이상혁 (차의과학대학교 분당차병원 정신건강의학과)
  • Received : 2018.08.03
  • Accepted : 2018.12.20
  • Published : 2019.04.30

Abstract

Objectives Disrupted integrities of the fornix and stria terminalis have been suggested in schizophrenia. However, very few studies have focused on the fornix and stria terminalis comparing first-episode schizophrenia (FESZ), chronic schizophrenia (CS), and healthy controls (HCs) with the application of diffusion-tensor imaging (DTI) technique. The objective of this study is to compare the connectivity of the fornix and stria terminalis among FESZ, CS, and HCs. Methods We included the 44 FESZ patients, 39 CS patients and 20 HCs in this study. Voxel-wise statistical analysis of the fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics to analyze the connectivity of fornix and stria terminalis. In addition, the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were used to evaluate clinical symptom severities. Results There were no significant differences between the FESZ, CS, and HCs in age, sex, education years. The SAPS and SANS scores of the schizophrenia groups showed no significant differences. FA values of the right fornix cres/stria terminalis in the CS group were significantly lower than those in FESZ and HCs. There were no significant differences of FA values of the right fornix cres/stria terminalis between the FESZ and the HCs. Pearson correlation analyses revealed that significant correlation between FA values of the right fornix cres/stria terminalies of the the FESZ group and positive, negative symptom scales, and FA values of the right fornix cres/stria terminalis of the CS group and negative symptom scales. Conclusions This study shows that FA values of the fornix and stria terminalis in the CS were lower than in the FESZ and the HCs. These results suggest that the fornix and stria terminalis can play a role in pathophysiology of schizophrenia. Thus current study can broaden our understanding of the pathophysiology of schizophrenia.

Keywords

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