한국해양생명과학회지 (Journal of Marine Life Science)

한국해양생명과학회 (The Korean Society of Marine Life Science)
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해조류 유래 Fucoidan의 어류용 백신 항원보조제로서의 가능성에 대한 고찰

Potential of Fucoidan Extracted from Seaweeds as an Adjuvant for Fish Vaccine

  • 민은영 (국립수산과학원 병리연구과) ;
  • 김광일 (국립수산과학원 병리연구과) ;
  • 조미영 (국립수산과학원 병리연구과) ;
  • 정승희 (국립수산과학원 병리연구과) ;
  • 한현자 (국립수산과학원 병리연구과)
  • Min, Eun Young (Pathology Division, National Institute of Fisheries Science) ;
  • Kim, Kwang Il (Pathology Division, National Institute of Fisheries Science) ;
  • Cho, Mi Young (Pathology Division, National Institute of Fisheries Science) ;
  • Jung, Sung-Hee (Pathology Division, National Institute of Fisheries Science) ;
  • Han, Hyun-Ja (Pathology Division, National Institute of Fisheries Science)
  • 투고 : 2019.04.11
  • 심사 : 2019.06.04
  • 발행 : 2019.06.17
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초록

Fucoidan(후코이단)은 주로 갈조류에서 추출되는 fucose를 함유한 함황 다당류의 일종으로, 항균, 항바이러스 및 항종양 효과와 함께 다양한 경로로 면역력을 향상시키는 생리 기능성물질로 알려져 있다. 최근 연구에 따르면, 인체 백신 분야에서는 fucoidan의 백신 adjuvant(항원보조제)로서의 가능성이 제시되었다. 수산업 분야에서는, 보조사료로서의 fucoidan의 기능에 관한 연구는 보고되고 있으나, 수산용 백신 개발을 위한 adjuvant 연구는 전무한 실정이다. 동물세포에서 fucoidan의 adjuvant에 대한 긍정적인 검토와 함께 안전성을 증명한 연구는 많이 있지만, fucoidan을 어류 백신용 adjuvant로 사용하기 위해서는 어류에서도 이를 확인할 필요가 있다. 또한 fucoidan의 분자량에 따라 세포 내 흡수율이 각기 다르다는 점과 병원체의 인위감염에 따른 항체 생성을 포함한 어류의 특이면역 반응 시스템에 대한 연구가 많이 부족하다는 제약이 있다. 따라서 이러한 분야에 대한 적극적인 연구가 뒷받침 된다면 안전하고 효과적인 adjuvant로 사용할 수 있을 것이다. 본 연구에서는 fucoidan이 사람과 동물을 포함하여 어류의 면역자극 즉 체액성 및 세포성 면역에 미치는 영향에 대한 연구를 검토하고, 수산업 분야에서 fucoidan의 사용과 어류 백신용 adjuvant로서의 가능성을 고찰하였다.

Fucoidan is a physiologically functional ingredient extracted from seaweed brown algae, which is a sulfated polysaccharide containing fucose as a main molecule backbone. Fucoidan has a variety of immune-modulating or -stimulating effects, including promoting antigen uptake and enhancing anti-bacterial, anti-viral and anti-tumor effects. In addition, recent studies have suggested the possibility of use of fucoidan as a vaccine adjuvant in the field of human vaccine. Use of fucoidan as supplementary feeds have already been studied, but the development of fucoidan as an adjuvant of fish vaccine is still premature. However, the intracellular uptake of fucoidan differs depending on the molecular weight of fucoidan, and there is a limit to the study on specific immune response including the production of antibodies to fish caused by an artificial infection of pathogen. Although the safety of fucoidan has been demonstrated in animal cells, there is a need to confirm the safety of fucoidan in fish. Therefore, active research in this field is needed to use fucoidan as a vaccine adjuvant. This study discussed the effects of fucoidan on immune stimulation, humoraland cellular- immunity including humans and animals. The prospect of fucoidan as a vaccine adjuvant in fisheries also reviewed.

키워드

과제정보

이 논문은 2019년도 국립수산과학원 넙치 연쇄구균(Streptococcus parauberis) 백신의 개량 연구(R2019056)의 지원으로 수행된 연구입니다.

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