Journal of Marine Life Science (한국해양생명과학회지)

The Korean Society of Marine Life Science (한국해양생명과학회)
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Effects of Tiamulin on Starry Flounder, Platichthys stellatus Infected with Streptococcus parauberis HFTC0083

Tiamulin이 Streptococcus parauberis HFTC0083에 감염된 강도다리(Platichthys stellatus)에 미치는 영향

  • Joo, Min-Soo (Institute of Marine Industry, Department of Marine Biology and Aquaculture, College of Marine Science, Gyeongsang National University) ;
  • Kim, Boseong (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Kim, Do-Hyung (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Seo, Jung-Soo (Aquatic Life Disease Control Division, National Institute of Fisheries Science) ;
  • Kwon, Mun-Gyeong (Aquatic Life Disease Control Division, National Institute of Fisheries Science) ;
  • Jee, Bo-Young (Aquatic Life Disease Control Division, National Institute of Fisheries Science) ;
  • Park, Chan-Il (Institute of Marine Industry, Department of Marine Biology and Aquaculture, College of Marine Science, Gyeongsang National University)
  • 주민수 (경상대학교 해양과학대학 해양생명과학과) ;
  • 김보성 (부경대학교 수산생명의학과) ;
  • 김도형 (부경대학교 수산생명의학과) ;
  • 서정수 (국립수산과학원 수산방역과) ;
  • 권문경 (국립수산과학원 수산방역과) ;
  • 지보영 (국립수산과학원 수산방역과) ;
  • 박찬일 (경상대학교 해양과학대학 해양생명과학과)
  • Received : 2019.05.21
  • Accepted : 2019.06.11
  • Published : 2019.06.17
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Abstract

In order to control disease caused by multi-drug resistant bacteria in the aquaculture, the use of veterinary antibiotics, which are prohibited to fish, is increasing, instead of the existing fisheries antibiotics. Among them, tiamulin is illegally used in some cultured fish because it exhibits effective antibacterial activity against Gram-positive bacteria. To prevent unauthorized use, treatment of fish should be accompanied by a prescription from veterinarians or fisheries disease managers through research on fish of tiamulin. Tiamulin was injected intramuscularly at 5, 10 and 15 mg kg-1 for the streptococcus-infected starry flounder, but did not show any therapeutic effect. Oral administration at a concentration of 15 and 30 mg kg-1 was similarly ineffective. The concentrations of 30 and 60 mg kg-1 resulted in death due to toxicity of antibiotics. Therefore, it is inappropriate to treat antibiotics with streptococcus-infected starry flounder.

수산 양식 산업에서 발생하는 다제내성균에 의한 질병을 통제하기 위해 기존에 사용하던 수산용 의약품 대신 어류에 사용이 금지된 동물용 의약품 사용이 증가하고 있다. 그 중, 티아물린은 그람 양성균에 효과적인 항균성을 나타내기 때문에 일부 양식 어가에서 불법적으로 사용되고 있다. 불법적 사용을 막기 위해서는 티아물린의 수산동물에 대한 연구를 통해 수의사나 수산질병관리사의 처방전에 따라 수산생물의 치료행위가 수반되어야 한다. 연쇄구균에 감염된 강도다리에 대해 티아물린을 5, 10, 15 mg kg-1의 농도로 근육주사 하였으나 치료 효과가 나타나지 않았고 15, 30 mg kg-1의 농도로 경구투여 하였으나 마찬가지로 치료 효과가 미비하였다. 안전성 확인을 위해 30, 60 mg kg-1의 농도로 근육주사와 경구투여한 경우 항생제의 독성에 의한 폐사가 발생하였고 따라서 연쇄구균에 감염된 강도다리에 티아물린으로 항생제 처리를 하는 것은 부적절하다고 할 수 있다.

Keywords

Acknowledgement

이 논문은 2019년 해양수산부 재원으로 해양수산과학기술진흥원의 지원을 받아 수행된 연구임(스마트 수산양식 연구센터).

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