Korean Journal of Radiology

  • 제20권5호
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  • Pages.830-843
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  • 2019
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

  • Yongfang Wang (Department of Radiology, First Hospital of China Medical University) ;
  • Xin Zhang (Department of Radiology, First Hospital of China Medical University) ;
  • Bin Wang (Department of Radiology, First Hospital of Shanxi Medical University) ;
  • Yang Xie (Department of Radiology, First Hospital of China Medical University) ;
  • Yi Wang (Department of Radiology, The Qianfoshan Hospital of Shandong Province) ;
  • Xuan Jiang (Cardiac Surgery, First Hospital of China Medical University) ;
  • Rongjia Wang (Department of Radiology, First Hospital of China Medical University) ;
  • Ke Ren (Department of Radiology, First Hospital of China Medical University)
  • 투고 : 2018.10.29
  • 심사 : 2019.01.03
  • 발행 : 2019.05.01
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초록

Objective: To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model. Materials and Methods: Sixty-two rabbits were randomized into 2 groups: diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points. Iohexol was administrated at a dose of 2.5 g I/kg of body weight. Further, the apparent transverse relaxation rate (R2*), average pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f) were calculated. Results: The D and f values of the renal cortex (CO) and outer medulla (OM) were significantly decreased compared to baseline values in the 2 groups 1 day after the iohexol injection (p < 0.05). A marked reduction in the D* values for both the CO and OM was also observed after 1 hour in each group (p < 0.05). In the OM, a persistent elevation of the R2* was detected for 4 days in the DCA group (p < 0.05). Histopathological changes were prominent, and the pathological features of CI-AKI aggravated in the DCA group until day 4. The D, f, and R2* values significantly correlated with the histological damage scores, hypoxia-inducible transcription factor-1α expression scores, and serum creatinine levels. Conclusion: A combination of IVIM and BOLD imaging may serve as a noninvasive method for detecting and monitoring CI-AKI in the early stages in the diabetic kidney.

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과제정보

The authors thank GuiboYu for technical assistance (Key Laboratory of Imaging Diagnosis and Interventional Radiology of Liaoning Province, Shenyang, Liaoning, China).

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