Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection

  • Tsai, Hung-Chin (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Chen, Yu-Hsin (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Yen, Chuan-Min (Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University) ;
  • Chung, Li-Yu (Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University) ;
  • Wann, Shue-Ren (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Lee, Susan Shin-Jung (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Chen, Yao-Shen (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University)
  • Received : 2019.02.03
  • Accepted : 2019.04.09
  • Published : 2019.06.30
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Abstract

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform ${\beta}$ and ${\gamma}$ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 ${\beta}$, ${\gamma}$, ${\varepsilon}$, and ${\theta}$ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

Keywords

References

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