Investigative Magnetic Resonance Imaging

  • 제23권2호
  • /
  • Pages.148-156
  • /
  • 2019
  • /
  • 2384-1095(pISSN)
  • /
  • 2384-1109(eISSN)
대한자기공명의과학회 (Korean Society of Magnetic Resonance in Medicine)
권호 표지
DOI QR코드

DOI QR Code

Multi-Parametric Quantitative MRI for Measuring Myelin Loss in Hyperglycemia-Induced Hemichorea

  • Youn, Sung Won (Department of Radiology, Catholic University of Daegu Medical Center) ;
  • Kwon, Oh Dae (Department of Neurology, Catholic University of Daegu Medical Center) ;
  • Hwang, Moon Jung (MR Application and Workflow, GE Healthcare)
  • 투고 : 2019.02.19
  • 심사 : 2019.05.10
  • 발행 : 2019.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Hyperglycemia-induced hemichorea (HGHC) is a rare but characteristic hyperkinetic movement disorder involving limbs on one side of the body. In a 75-year-old woman with a left-sided HGHC, conventional brain MR imaging showed very subtle T1-hyperintensity and unique gadolinium enhancement in the basal ganglia contralateral to movements. Multi-parametric MRI was acquired using pulse sequence with quantification of relaxation times and proton density by multi-echo acquisition. Myelin map was reconstructed based on new tissue classification modeling. In this case report of multi-parametric MRI, quantitative measurement of myelin change related to HGHC in brain structures and its possible explanations are presented. This is the first study to demonstrate myelin loss related to hyperglycemic insult in multi-parametric quantitative MR imaging.

키워드

참고문헌

  1. Oh SH, Lee KY, Im JH, Lee MS. Chorea associated with nonketotic hyperglycemia and hyperintensity basal ganglia lesion on T1-weighted brain MRI study: a meta-analysis of 53 cases including four present cases. J Neurol Sci 2002;200:57-62 https://doi.org/10.1016/S0022-510X(02)00133-8
  2. Wintermark M, Fischbein NJ, Mukherjee P, Yuh EL, Dillon WP. Unilateral putaminal CT, MR, and diffusion abnormalities secondary to nonketotic hyperglycemia in the setting of acute neurologic symptoms mimicking stroke. AJNR Am J Neuroradiol 2004;25:975-976
  3. Nath J, Jambhekar K, Rao C, Armitano E. Radiological and pathological changes in hemiballism-hemichorea with striatal hyperintensity. J Magn Reson Imaging 2006;23:564-568 https://doi.org/10.1002/jmri.20548
  4. Chu K, Kang DW, Kim DE, Park SH, Roh JK. Diffusionweighted and gradient echo magnetic resonance findings of hemichorea-hemiballismus associated with diabetic hyperglycemia: a hyperviscosity syndrome? Arch Neurol 2002;59:448-452 https://doi.org/10.1001/archneur.59.3.448
  5. Warntjes JB, Leinhard OD, West J, Lundberg P. Rapid magnetic resonance quantification on the brain: Optimization for clinical usage. Magn Reson Med 2008;60:320-329 https://doi.org/10.1002/mrm.21635
  6. Hagiwara A, Warntjes M, Hori M, et al. SyMRI of the brain: rapid quantification of relaxation rates and proton density, with synthetic MRI, automatic brain segmentation, and myelin measurement. Invest Radiol 2017;52:647-657 https://doi.org/10.1097/RLI.0000000000000365
  7. Hagiwara A, Hori M, Yokoyama K, et al. Utility of a Multiparametric quantitative MRI model that assesses myelin and edema for evaluating plaques, periplaque white matter, and normal-appearing white matter in patients with multiple sclerosis: a feasibility study. AJNR Am J Neuroradiol 2017;38:237-242 https://doi.org/10.3174/ajnr.A4977
  8. Warntjes M, Engstrom M, Tisell A, Lundberg P. Modeling the presence of myelin and edema in the brain based on multi-parametric quantitative MRI. Front Neurol 2016;7:16
  9. Laule C, Leung E, Lis DK, et al. Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology. Mult Scler 2006;12:747-753 https://doi.org/10.1177/1352458506070928
  10. Tan Y, Xin X, Xiao Q, Chen S, Cao L, Tang H. Hemiballismhemichorea induced by ketotic hyperglycemia: case report with PET study and review of the literature. Transl Neurodegener 2014;3:14 https://doi.org/10.1186/2047-9158-3-14