Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Inflammation and Oxidative Stress as related to Airflow Limitation Severity in Retired Miners with Chronic Obstructive Pulmonary Disease

광산 이직근로자의 만성폐쇄성폐질환 기류제한 중증도와 염증 및 산화스트레스

  • Lee, Jong Seong (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Shin, Jae Hoon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Baek, Jin Ee (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Jeong, Ji Yeong (Department of Medical Biotechnology, Dong-A University) ;
  • Choi, Byung-Soon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service)
  • 이종성 (근로복지공단 직업환경연구원) ;
  • 신재훈 (근로복지공단 직업환경연구원) ;
  • 백진이 (근로복지공단 직업환경연구원) ;
  • 정지영 (동아대학교 의약생명공학과) ;
  • 최병순 (근로복지공단 직업환경연구원)
  • Received : 2019.04.29
  • Accepted : 2019.06.07
  • Published : 2019.06.30
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Abstract

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Inflammation and oxidative stress are associated with COPD. The aim of this study was to evaluate the relationship among inflammation, oxidative stress, and airflow limitation severity in retired miners with COPD. Methods: The levels of serum high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation, degree of reactive oxygen metabolites(dROMs) and biological antioxidants potential(BAP) in plasma as biomarkers for oxidative stress were measured in 211 male subjects with COPD. Degree of airflow limitation severity as determined by spirometry was divided into three grades grouped according to the classification of the Global Initiatives for Obstructive Lung Disease(GOLD)(1, mild; 2, moderate; $3{\leq}$, severe or more) using a fixed ratio, post- bronchodilator $FEV_1/FVC$ < 0.7. Results: Mean levels of dROMs significantly increased in relation to airflow limitation severity(GOLD 1, 317.8 U.CARR vs. GOLD 2, 320.3 U.CARR vs. GOLD $3{\leq}$, 350.9 U.CARR, p=0.047) and dROMs levels were correlated with serum hsCRP levels(r=0.514, p<0.001). Mean levels of hsCRP were higher in current smokers(non-smoker, 1.47 mg/L vs. smoker, 2.34 mg/L, p=0.006), and tended to increase with degree of airflow limitation severity(p=0.071). Mean levels of BAP were lower in current smokers(non-smoker, $1873{\mu}mol/L$ vs. smoker, $1754{\mu}mol/L$, p=0.006). Conclusions: These results suggest that inflammation and oxidative stress are related to airflow limitation severity in retired miners with COPD, and there was a correlation between inflammation and oxidative stress.

Keywords

Table 1. General characteristics of the study subjects(N=211)

SOOSB1_2019_v29n2_251_t0001.png 이미지

Table 2. Mean levels of biomarkers as related to general characteristics

SOOSB1_2019_v29n2_251_t0002.png 이미지

Table 3. Covariate-adjusted levels of biomarkers among the study groups

SOOSB1_2019_v29n2_251_t0003.png 이미지

References

  1. Agusti A. Thomas a. Neff lecture. Chronic obstructive pulmonary disease-a systemic disease. Proc Am Thorac Soc 2006;3:478-481(DOI:10.1513/pats.200603-058MS)
  2. Anderson SC & Cockayne S. Clinical Chemistry. Concepts & applications. New York, The McGraw-Hill Co.; 2003. P.298, p.378-380
  3. Babior BM. NADPH-oxidase: an update. Blood, 1999;93(5):1464-1476(PMID:10029572) https://doi.org/10.1182/blood.v93.5.1464
  4. Balmes J, Becklake M, Blanc P, Henneberger P, Kreiss K et al. American Thoracic Society Statement: Occupational contribution to the burden of airway disease. Am J Respir Crit Care Med 2003;167(5):787-797(DOI:10.1164/rccm.167.5.787)
  5. ben Anes A, Fetoui H, Bchir S, ben Nasr H, Chahdoura H et al. Increased oxidative stress and altered levels of nitric oxide and peroxynitrite in Tunisian patients with chronic obstructive pulmonary disease: correlation with disease severity and airflow obstruction. Biol Trace Elem Res 2014;161(1):20-31(DOI:10.1007/ s12011-014-0087-4)
  6. Bergdahl IA, Toren K, Eriksson K, Hedlund U, Nilsson T et al. Increased mortality in COPD among construction workers exposed to inorganic dust. Eur Respir J 2004;23:402-406(DOI:10.1183/09031936.04.00034304)
  7. Chen YW, Leung JM, Sin DD. A systematic review of diagnostic biomarkers of COPD exacerbation. PLoS One 2016;11(7):e0158843(DOI:10.1371/journal.pone.0158843)
  8. Choi JK, Paek DM, Lee JO. Normal predictive values of spirometry in Korean population. Tuberc Respir Dis. 2005;58:230-242(DOI:http://dx.doi.org/10.4046/trd.2005.58.3.230)
  9. Coggon D & Anthony Newman TA. Coal mining and chronic obstructive pulmonary disease: a review of the evidence. Thorax 1998;53:398-407(PMID:9708233) https://doi.org/10.1136/thx.53.5.398
  10. Cohen RAC, Patel A, Green FHY. Lung disease caused by exposure to coal mine and silica dust. Semin Respir Crit Care Med 2008;29:651-661(DOI:10.1055/s-0028-1101275)
  11. Foschino Barbaro MP, Carpagnano GE, Spanevello A, Cagnazzo MG, Barnes PJ. Inflammation, oxidative stress and systemic effects in mild chronic obstructive pulmonary disease. Int J Immunopathol Pharmacol 2007;20(4):753-763(DOI:10.1177/039463200702000411)
  12. Fukui T, Yamauchi K, Maruyama M, Yasuda T, Kohno M et al. Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects. Hypertens Res 2011;34(9):1041-1045 (PMID:19403985) https://doi.org/10.1038/hr.2011.76
  13. Gan WQ, Man SFP, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004;59:574-580(DOI:10.1136/thx.2003.019588)
  14. Gao X, Gao X, Zhang Y, Breitling LP, Schottker B et al. Associations of self-reported smoking, cotinine levels and epigenetic smoking indicators with oxidative stress among older adults: a populationbased study. Eur J Epidemiol 2017;32(5):443-456 (DOI:10.1007/s10654-017-0248-9)
  15. Gulumian M, Borm PJA, Vallyathan, Castranova V, Donaldson K et al. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review. J Toxicol Environ Health, Part B 2006;9:357-395(DOI:10.1080/ 15287390500196537)
  16. Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem, 1995;41(12 Pt 2):1819-28(PMID:7497639) https://doi.org/10.1093/clinchem/41.12.1819
  17. Hanta I, Kocabas A, Canacankatan N, Kuleci S, Seydaoglu G. Oxidant-antioxidant balance in patients with COPD. Lung 2006;184(2):51-55(DOI:10.1007/s00408-005-2561-4)
  18. Hirose H, Kawabe H, Komiya N, Saito I. Relations between serum reactive oxygen metabolites(ROMs) and various inflammatory and metabolic parameters in a Japanese population. J Atheroscler Thromb 2009;16(2):77-82(PMID:19403985) https://doi.org/10.5551/jat.E265
  19. Hnizdo E, Sullivan PA, Bang KM, Wagner G. Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: A study of data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2002;156(8):738-746(PMID:12370162) https://doi.org/10.1093/aje/kwf105
  20. Karadag F, Kirdar S, Karul AB, Ceylan E. The value of C-reactive protein as a marker of systemic inflammation in stable chronic obstructive pulmonary disease. Eur J Intern Med 2008;19(2):104-108(DOI:10.1016/ j.ejim.2007.04.026)
  21. KATRD(Korean academy of tuberculosis and respiratory diseases). Guideline for COPD and asthma. Seoul:Seoul Medcus; 2005. p. 26-27
  22. Kirkham PA & Barnes PJ. Oxidative stress in COPD. Chest 2013;144(1):266-27( DOI:10.1378/chest.12-2664)
  23. Koechlin C, Couillard A, Cristol JP, Chanez P, Hayot M et al. Does systemic inflammation trigger local exerciseinduced oxidative stress in COPD? Eur Respir J 2004;23(4):538-544(PMID:15083751) https://doi.org/10.1183/09031936.04.00069004
  24. Kostikas K, Papatheodorou G, Psathakis K, Panagou P, Loukides S: Oxidative stress in expired breath condensate of patients with COPD. Chest 2003;124(4):1373-1380(PMID:14555568) https://doi.org/10.1378/chest.124.4.1373
  25. Larsson K. Aspects on pathophysiological mechanisms in COPD. J Intern Med 2007;262(3):311-340 (DOI:10.1111/j.1365-2796.2007.01837.x)
  26. Lamprecht B, McBurnie MA, Vollmer WM, Gudmundsson G, Welte T et al. COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest 2011;139(4):752-763 (DOI:10.1378/chest.10-1253)
  27. MacNee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005;2(1):50-60(DOI:10.1513/pats.200411-056SF)
  28. Mak JC. Pathogenesis of COPD. Part II. Oxidativeantioxidative imbalance. Int J Tuberc Lung Dis 2008;12(4):368-374(PMID:18371260)
  29. Markoulis N, Gourgoulianis KI, Moulas A, Gerogianni E, Molyvdas AP. Reactive oxygen metabolites as an index of chronic obstructive pulmonary disease severity. Panminerva Med 2006;48(4):209-213 (PMID:17215792)
  30. Meijers JM, Swaen GM, Slangen JJ. Mortality of Dutch coal miners in relation to pneumoconiosis, chronic obstructive pulmonary disease, and lung function. Occup Environ Med 1997;54(10):708-713 (PMID:9404317) https://doi.org/10.1136/oem.54.10.708
  31. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R et al. Standardisation of spirometry. Eur Respir J 2005;26:319-338(DOI:10.1183/09031936.05.00034805)
  32. Morimoto M, Satomura S, Hashimoto T, Ito E, Kyotani S. Oxidative stress measurement and prediction of epileptic seizure in children and adults with severe motor and intellectual disabilities. J Clin Med Res 2016;8(6):437-444(DOI:10.14740/jocmr2534w)
  33. Pepys MB & Hirschfield GM. "C-reactive protein: a critical update". J Clin Invest 2003;111(12):1805-1812 (DOI:10.1172/JCI18921)
  34. Pryor WA. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity. Environ Health Perspect 1997;105(4):875-882 (DOI:10.1289/ehp.97105s4875)
  35. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA et al. Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176(6):532-555(DOI:10.1164/rccm.200703-456SO)
  36. Rahman I, Swarska E, Henry M, Stolk J, MacNee W. Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax 2000;55(3):189-193(PMID:10679536) https://doi.org/10.1136/thorax.55.3.189
  37. Repine JE, BAST A, Lankhorst I, The Oxidative stress study group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997;156(2 Pt 1):341-357(DOI:10.1164/ajrccm.156.2. 9611013)
  38. Schins RPF & Borm PJA. Mechanisms and mediators in coal dust induced toxicity: A review. Am Occup Hyg 1999;43(1):7-33(PMID:10028891) https://doi.org/10.1016/S0003-4878(98)00069-6
  39. Sethi JM & Rochester CL. Smoking and chronic obstructive pulmonary disease. Clin Chest Med 2000;21(1):67-86(PMID:10763090) https://doi.org/10.1016/S0272-5231(05)70008-3
  40. Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A et al. Evaluation of oxidative stress and antioxidant status in chronic obstructive pulmonary disease. Scand J Immunol 2017;85(2):130-137(DOI:10.1111/ sji.12498)
  41. Stanojkovic I, Kotur-Stevuljevic J, Spasic S, Milenkovic B, Vujic T et al. Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation. Clin Biochem 2013;46(16-17):1678-1682(DOI:10.1016/j.clinbiochem.2013.08.003)
  42. Strassmann R, Bausch B, Spaar A, Kleijnen J, Braendli O et al. Smoking cessation interventions in COPD: a network meta-analysis of randomised trials. Eur Respir J 2009;34: 634-640(DOI:10.1183/09031936.00167708)
  43. Su B, Liu T, Fan H, Chen F, Ding H et al. Inflammatory markers and the risk of chronic obstructive pulmonary disease: A systematic review and metaanalysis. PLoS One 2016;11(4):e0150586 (DOI: 10.1371/journal.pone.0150586)
  44. Sun Y. Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biol Med 1990;8:583-599 (PMID:2193855) https://doi.org/10.1016/0891-5849(90)90156-D
  45. Tkacova R, Kluchova Z, Joppa P, Petrasova D, Molcanyiova A. Systemic inflammation and systemic oxidative stress in patients with acute exacerbations of COPD. Respir Med 2007;101(8):1670-1676 (DOI:10.1016/j.rmed.2007.03.005)
  46. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 Report: GOLD executive summary. Eur Respir J 2017; 49: 1700214(DOI:10.1183/13993003.50214-2017)