The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effects of Improving Plasma Lipid Profiles and Antioxidant Metabolism of Superjami Extract Supplementation

슈퍼자미벼 미강 추출물 보충 섭취에 의한 항산화 대사 및 혈중 지질 개선 효과

  • Nam, Su-Jin (Dept. of Food Sciences and Nutrition, Kyungpook National University) ;
  • Chung, Soo-Im (International Agricultural Training Center, Kyungpook National University) ;
  • Kang, Mi-Youn (Dept. of Food Sciences and Nutrition, Kyungpook National University)
  • 남수진 (경북대학교 식품영양학과) ;
  • 정수임 (경북대학교 농업과학기술연구소) ;
  • 강미영 (경북대학교 식품영양학과)
  • Received : 2019.01.31
  • Accepted : 2019.05.10
  • Published : 2019.06.30
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Abstract

This study was to confirm the effect of supplementation of superjami bran extract on lipid and antioxidant metabolism. Twenty-five subjects were recruited, and divided into Superjami group (n=12), and Placebo group (n=13) random assignment. Among the groups, the Superjami group took a Superjami bran extract (2 g/2 capsule/day), and the Placebo group took dextrin (2 g/2 capsule/day), for 12 weeks. As a result of the experiment, concentrations of TG, TC, and HDL-C in the blood, were significantly lower than those in the control group, and HDL-C was significantly higher. AI and HTR also showed positive values. Leptin did not differ significantly, but as a result of adipectin, the Superjami group displayed a higher value, compared to the Placebo group, and LAR also had significantly lower value. Antioxidant results showed that GPx, CAT, and RGLU, were significantly higher before as well as after intakes of the Superjami group, and significantly higher levels of the Superjami group, compared to the Placebo group. AOPP showed significantly lower values for the Superjami group, compared to the Placebo group. So, based on this study, ingestion of Superjami bran extract is effective in improving blood lipid concentrations as well as inflammatory substances, and has positive effects relative to increasing antioxidant activity.

Keywords

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Fig. 1. Experimental design for a trial.

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Fig. 2. Changes of plasma CAT, GPx, RGLU and AOPP concentration in subjects fed extract of Superjami rice bran.

Table 1. The average values of anthropometric measurements in subjects

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Table 2. Changes of plasma lipid profile, TBARS, GOT and GPT concentration in subjects fed extract of Superjami rice bran

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Table 3. Changes of plasma leptin, adiponectin and LAR concentration in subjects fed extract of Superjami rice bran

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References

  1. Akcakaya H, Tok S, Dal F, Cinar SA, Nurten R. 2017. ${\beta}$-Carotene treatment alters the cellular death process in oxidative stress-induced K562 cells. Cell Biol Int 41:309-319 https://doi.org/10.1002/cbin.10727
  2. Bae HJ, Rio CW, Ryu SN, Kang MY. 2014. Hypolipidemic, hypoglycemic, and antioxidative effects of a new pigmented rice cultivar “Superjami” in high fat-fed mice. J Korean Soc Appl Biol Chem 57:685-691 https://doi.org/10.1007/s13765-014-4095-z
  3. Bast A, Haenen GR, Doelman CJ. 1991. Oxidants and antioxidants: state of the art. Am J Med 91:S2-S13
  4. Block G. 1992. The data support a role for antioxidants in reducing cancer risk. Nutr Rev 50:207-213 https://doi.org/10.1111/j.1753-4887.1992.tb01329.x
  5. Bonomini F, Rodella LF, Rezzani R. 2015. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 6:109-120 https://doi.org/10.14336/AD.2014.0305
  6. Campos H, Wilson PW, Jimenez D, Mcnamara JR, Ordovas J, Schaefer EJ. 1990. Differences in apolipoproteins and lowdensity lipoprotein subfractions in postmenopausal women on and off estrogen therapy: Results from the framingham offspring study. Metabolism 39:1033-1038 https://doi.org/10.1016/0026-0495(90)90162-6
  7. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. 1996. Leptin: The tale of an obesity gene. Diabetes 45:1455-1462 https://doi.org/10.2337/diab.45.11.1455
  8. Chen J, He J, Hamm L, Batuman V, Whelton PK. 2002. Serum antioxidant vitamins and blood pressure in the United States population. Hypertension 40:810-816 https://doi.org/10.1161/01.HYP.0000039962.68332.59
  9. Cho JH, Song YC, Lee KS, Choi SW, Lee MJ, Jang KC, Kim HY, Kang HJ, Park KD, Seo WD. 2017. Physicochemical characteristics of cultivated aromatic rice germplasm and comparative analysis of flavor components during transplanting time. Korean J Environ Agric 36:175-183 https://doi.org/10.5338/KJEA.2017.36.3.26
  10. Choi HJ, Yoon JH, Kim SH, Yoon KS, Hong SH. 2007. Effect of lipid profile and inflammatory marker on serum ${\gamma}$-GT in pre- and post-menopausal women. J Korean Soc Menopause 13:14-20 https://doi.org/10.1258/175404507780456782
  11. Choi SP, Kim SP, Kang MY, Nam SH, Friedman M. 2010. Protective effects of black rice bran against chemicallyinduced inflammation of mouse skin. J Agri Food Chem 58:10007-11015 https://doi.org/10.1021/jf102224b
  12. Choi Y, Jeong HS, Lee J. 2007. Antioxidant activity of methanolic extracts from some grains consumed in Korea. Food Chem 103:130-138 https://doi.org/10.1016/j.foodchem.2006.08.004
  13. Choung MG, Lim JD. 2012. Antioxidant, anticancer and immune activation of anthocyanin fraction from Rubus coreanus Miquel fruits (Bokbunja). Korean J Med Crop Sci 20:259-269 https://doi.org/10.7783/KJMCS.2012.20.4.259
  14. Chung SI, Lee SC, Kang MY. 2017. Physicochemical properties of giant embryo rice Seonong 17 and Keunnunjami. Biosci Biotechnol Biochem 81:972-978 https://doi.org/10.1080/09168451.2016.1277510
  15. Chung SI, Ryu SN, Kang MY. 2016. Germinated pigmented rice (Oryza sativa L. cv. Superhongmi) improves glucose and bone metabolisms in ovariectomized rats. Nutrients 8:E658 https://doi.org/10.3390/nu8100658
  16. Cicero AFG, Derosa G. 2005. Rice bran and its main components: potential role in the management of coronary risk factors. Curr Top Nutraceutical Res 3:29-46
  17. Codoner-Franch P, Tavarez-Alonso S, Murria-Estal R, Tortajada-Girbes M, Simo-Jorda R, Alonso-Iglesias E. 2012. Elevated advanced oxidation protein products (AOPPs) indicate metabolic risk in severely obese children. Nutr Metab Cardiovasc Dis 22:237-243 https://doi.org/10.1016/j.numecd.2010.06.002
  18. Deisseroth A, Dounce AL. 1970. Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role. Physiol Rev 50:319-375 https://doi.org/10.1152/physrev.1970.50.3.319
  19. Diaz MN, Frei B, Vita JA, Keaney JF Jr. 1997. Antioxidants and atherosclerotic heart disease. N Eng J Med 337:408-416 https://doi.org/10.1056/NEJM199708073370607
  20. Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC. 2007. Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women. Am J Clin Nutr 85:910-918 https://doi.org/10.1093/ajcn/85.3.910
  21. Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Cli Chem 18:499-502 https://doi.org/10.1093/clinchem/18.6.499
  22. Godala MM, Materek-Kusmierkiewicz I, Moczulski D, Rutkowski M, Szatko F, Gaszynska E, Tokarski S, Kowalski J. 2016. Lower plasma levels of antioxidant vitamins in patients with metabolic syndrome: A case control study. Adv Cin Exp Med 25:689-700 https://doi.org/10.17219/acem/41049
  23. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, SmithJr SC, Spertus JA, Costa F. 2005. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735-2752 https://doi.org/10.1161/CIRCULATIONAHA.105.169404
  24. Gu BS. 1996. Gynecology endocrinology. Goryeo Med Sci 481-489
  25. Ham TH, Kwon SW, Ryu SN, Koh HJ. 2015. Correlation analysis between grain color and cyanidin-3-glucoside content of rice grain in segregate population. Plant Breed Biotechnol 3:160-166 https://doi.org/10.9787/PBB.2015.3.2.160
  26. Ham TH, Kwon SW, Ryu SN. 2017. A late maturing and high content of cyanidin 3-glucoside (C3G) rice variety 'Neugeunsuperjami'. Korean J Breed Sci 49:47-51 https://doi.org/10.9787/KJBS.2017.49.1.47
  27. Hamann A, Matthaei S. 1996. Regulation of energy balance by leptin. Exp Clin Endocrinol Diabetes 104:293-300 https://doi.org/10.1055/s-0029-1211457
  28. Hiramatsu K, Nishida J, Naito A, Yoshikura H. 1987. Molecular cloning of the closed circular provirus of human T cell leukaemia virus type I: A new open reading frame in the Gag-Pol region. J gen Virol 68:213-218 https://doi.org/10.1099/0022-1317-68-1-213
  29. Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. 2000. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol 35:1860-1866 https://doi.org/10.1016/S0735-1097(00)00616-1
  30. Hong HC, Kim YG, Choi YH, Yang SJ, Lee KS, Lee JH, Jung OY, Yang CI, Cho YC, Choi IS, Baek MK, Kim MK, Yea JD, Hwang HG, Roh JH, Kim SL, Choi HC, Lee YT, Lee SH. 2012a. A medium-maturing, giant-embryo, and germination brown rice cultivar 'Keunnun'. Korean J Breed Sci 44:160-164
  31. Hong S, Song YJ, Lee KH, Lee HS, Lee MS, Lee SH, Joung HJ. 2012b. A fruit and dairy dietary pattern is associated with a reduced risk of metabolic syndrome. Metabolism 61:883-890 https://doi.org/10.1016/j.metabol.2011.10.018
  32. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. 2000. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Bio 20:1595-1599 https://doi.org/10.1161/01.ATV.20.6.1595
  33. Ishikawa S, Kayaba K, Gotoh T, Nakamura Y, Kajii E. 2007. Metabolic syndrome and C-reactive protein in the general population: JMS Cohort Study. Circ J 71:26-31 https://doi.org/10.1253/circj.71.26
  34. Jacob RA. 1995. The integrated antioxidant system. Nutr Res 15:755-766 https://doi.org/10.1016/0271-5317(95)00041-G
  35. Jang HH, Park MY, Kim HW, Lee YM, Hwang KA, Park JH, Park DS, Kwon O. 2012. Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. Nutr Metab (Lond) 9:27 https://doi.org/10.1186/1743-7075-9-27
  36. Jang WS, Seo CR, Jang HH, Song NJ, Kim JK, Ahn JY, Han JJ, Seo WD, Lee YM, Park KW. 2015. Black rice (Oryza sativa L.) extracts induce osteoblast differentiation and protect against bone loss in ovariectomized rats. Food Funct 6:265-275 https://doi.org/10.1039/c4fo00836g
  37. Jun SY, Hong EJ, Joung HJ. 2015. Flavonoid intake according to food security in Korean adults: Based on the Korea National Health and Nutrition Examination Survey 2007- 2012. J Nutr Health 48:507-518 https://doi.org/10.4163/jnh.2015.48.6.507
  38. Jun SY, Shin SA, Joung HJ. 2016. Estimation of dietary flavonoid intake and major food sources of Korean adults. Br J Nutr 115:480-489 https://doi.org/10.1017/S0007114515004006
  39. Kang JS, Kang HS, Yun EK, Choi HR. 2012. Factors influencing health behavior compliance of patients with metabolic syndrome. Korean J Adult Nurs 24:191-199 https://doi.org/10.7475/kjan.2012.24.2.191
  40. Kim DJ, Choi SM, Kim HY, Kim JH, Ryu SN, Han SJ, Hong SG. 2011b. Evaluation of biological activities of fermented rice bran from novel black colored rice cultivar SuperC3GHi. Korean J Crop Sci 56:420-426 https://doi.org/10.7740/kjcs.2011.56.4.420
  41. Kim DJ, Ryu SN, Han SJ, Kim HY, Kim JH, Hong SG. 2011a. In vivo immunological activity in fermentation with black rice bran. Korean J Food Nutr 24:273-281 https://doi.org/10.9799/ksfan.2011.24.3.273
  42. Kim EO, Oh JH, Lee KT, Im JG, Kim SS, Suh HS, Choi SW. 2008a. Chemical compositions and antioxidant activity of the colored rice cultivars. Korean J Food Preserv 15:118-124
  43. Kim HJ, Cha JY, Choi ML, Cho YS. 2000. Antioxidative activities by water-soluble extracts of Morus alba and Cudrania tricuspidata. J Korean Soc Appl Biol Chem 43:148-152
  44. Kim HY, Kim JH, Lee SA, Ryu SN, Han SJ, Hong SG. 2010. Antioxidative and anti-diabetic activity of C3GHi, novel black rice breed. Korean J Crop Sci 55:38-46
  45. Kim JS, Ahn SN, Cho YH, Gwag JG, Kim TS, Lee JR, Lee SY. 2008b. Estimation of agronomic characteristics of domestic aromatic rice germplasm and foreign aromatic rice germplasm in RDA genebank, Korea. Korean J Crop Sci 53:261-272
  46. Kim JS, Park OS, Ahn SN, Lee JR, Gwag JG, Kim TS, Lee SY. 2008c. Quantification of 2-acetyl-1-pyrroline from the aroma rice germplasm by gas chromatography. Korean J Food Sci Technol 40:516-521
  47. Kim KB, Choi SK, Kim DS. 2012. Physicochemical properties and antioxidant activity of Superjami. Korean J Food Cook Sci 28:789-796 https://doi.org/10.9724/kfcs.2012.28.6.789
  48. Kim SA, Jun SY, Joung HJ. 2016. Estimated dietary intake of vitamin A in Korean adults: based on the Korea National Health and Nutrition Examination Survey 2007-2012. J Nutr Health 49:258-268 https://doi.org/10.4163/jnh.2016.49.4.258
  49. Kim YH, Hong SP, Yang R. 1995. Differential scanning calorimetry of skin collagen. Korean J Food Sci Technol 27:571-575
  50. Kim YW. 2007. Leptin resistance. Korean Endocr Soc 22:311-316 https://doi.org/10.3803/jkes.2007.22.5.311
  51. Koh HJ, Park SZ, Won YJ, Heu MH. 1993. Nutritional and agronomic characteristics of super-giant embryo mutant in rice. Korean J Crop Sci 38:537-544
  52. Koleva DI, Orbetzova MM, Atanassova PK. 2013. Adipose tissue hormones and appetite and body weight regulators in insulin resistance. Folia Medi (Plovdiv) 55:25-32 https://doi.org/10.2478/folmed-2013-0002
  53. Lee HH, Kim HY, Koh HJ, Ryu SN. 2006. Varietal difference of chemical composition in pigmented rice varieties. Korean J Crop Sci 51:113-118
  54. Lee KH, Kim YH, Park EJ, Cho SR. 2008. Study on dietary habit and effect of onion powder supplementation on serum lipid levels in early diagnosed hyperlipidemic patients. J Korean Soc Food Sci Nutr 37:561-570 https://doi.org/10.3746/jkfn.2008.37.5.561
  55. Liu H, Han T, Tian J, Zhu ZY, Liu Y, Li Y, Xiao SX, Li Y, Feng YY. 2012. Monitoring oxidative stress in acute-onchronic liver failure by advanced oxidation protein products. Hepatol Res 42:171-180 https://doi.org/10.1111/j.1872-034X.2011.00911.x
  56. Machlin LJ, Bendich A. 1987. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1:441-445 https://doi.org/10.1096/fasebj.1.6.3315807
  57. Nemzer BV, Rodriguez LC, Hammond L, Disilvestro R, Hunter JM, Pietrzkowski Z. 2011. Acute reduction of serum 8-iso-$PGF_{2}$-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage: A pilot clinical study with phytochemical and in vitro antioxidant characterization. Nutr J 10:67 https://doi.org/10.1186/1475-2891-10-67
  58. Nizamutdinova IT, Jin YC, Chung JI, Shin SC, Lee SJ, Seo HG, Lee JH, Chang KC, Kim HJ. 2009. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res 53:1419-1429 https://doi.org/10.1002/mnfr.200800526
  59. Noda M, Rodan GA. 1989. Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone. J Cell Biol 108:713-718 https://doi.org/10.1083/jcb.108.2.713
  60. Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, Kakizawa H, Hayakawa N, Suzuki A, Takeda J, Horikawa Y, Itoh M. 2008. The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metababolism 57:268-273 https://doi.org/10.1016/j.metabol.2007.09.011
  61. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y. 2000. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Cirulation 102:1296-1301 https://doi.org/10.1161/01.CIR.102.11.1296
  62. Park DS, Hwang UH, Park SK, Lee JH, Han SI, Cho JH, Lee JY, Oh SH, Jang KC, Seo WD, Shin DJ, Kim SY, Song YC, Yeo US, Park NB, Nam MH, Lee JK. 2015. A waxy black giant embryo early maturing rice variety 'Nunkeunheugchal'. Korean J Breed Sci 47:68-74 https://doi.org/10.9787/KJBS.2015.47.1.068
  63. Park JH, Lee JY, Chun JB, You OJ, Son EH. 2018. Multivariate analysis of variation of growth and quality characteristics in colored rice germplasm. Korean J Crop Sci 63:175-185 https://doi.org/10.7740/kjcs.2018.63.3.175
  64. Park JS, Kim MH. 2011. Anti-inflammatory effects of rice bran ethanol extract in murine macrophage RAW 264.7 cells. J Pharm Soc Korea 55:456-461
  65. Park TS, Lee SY, Kim HJ, Kim KT, Kim YJ, Jeong IH, Do WN, Lee HJ. 2009. Extracts of adlay, barley and rice bran have antioxidant activity and modulate fatty acid metabolism in adipocytes. Korean J Food Nutr 22:456-462
  66. Rana P, Vadhera S, Soni G. 2004. In vivo antioxidant potential of rice bran oil (RBO) in albino rats. Indian J Physiol Pharmacol 48:428-436
  67. Ross RK, Paganini-Hill A, Mack TM, Henderson BE. 1989. Cardiovascular benefits of estrogen replacement therapy. Am J Obstet Gynecol 160:1301-1306 https://doi.org/10.1016/S0002-9378(89)80017-1
  68. Slavin JL, Martini MC, Jacobs DR Jr, Marquart L. 1999. Plausible mechanisms for the protectiveness of whole grains. Am J Clin Nutr 70:459S-463S https://doi.org/10.1093/ajcn/70.3.459s
  69. Som S, Basu S, Mukherjee D, Deb S, Choudhury PR, Mukherjee S, Chatterjee SN, Chatterjee IB. 1981. Ascorbic acid metabolism in diabetes mellitus. Metabolism 30:572-577 https://doi.org/10.1016/0026-0495(81)90133-5
  70. Song SJ, Kim EK, Hong SY, Shin SA, Song YJ, Baik HW, Joung HJ, Paik HY. 2015. Low consumption of fruits and dairy foods is associated with metabolic syndrome in Korean adults from outpatient clinics in and near Seoul. Nutr Res Pract 9:554-562 https://doi.org/10.4162/nrp.2015.9.5.554
  71. Tiku ML, Allison GT, Naik K, Karry SK. 2003. Malondialdehyde oxidation of cartilage collagen by chondrocytes. Osteoarthritis Cartilage 11:159-166 https://doi.org/10.1016/S1063-4584(02)00348-5
  72. Tilg H, Moschen AR. 2006. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772-783 https://doi.org/10.1038/nri1937
  73. Van De Wier B, Koek GH, Bast A, Haenen GR. 2017. The potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Crit Rev Food Sci Nutr 57:834-855 https://doi.org/10.1080/10408398.2014.952399
  74. Wager JF, Hitt JC, Baukol BA, Bender JP, Keszler DA. 2002. Luminescent impurity doping trends in alternating-current thin-film electroluminescent phosphors. J Lumin 97:68-81 https://doi.org/10.1016/S0022-2313(01)00429-X
  75. Woo KM, Lee YS, Kim YH. 2005. Antioxidant effects of tocotrienol in rice bran. Korean Soc Crop Sci 50:4-7
  76. Wu Q, Zhong ZM, Pan Y, Zeng JH, Zheng S, Zhu SY, Chen JT. 2015. Advanced oxidation protein products as a novel marker of oxidative stress in postmenopausal osteoporosis. Med Sci Monit 21:2428-2432 https://doi.org/10.12659/MSM.894347
  77. Zawistowski J, Kopec A, Kitts DD. 2009. Effects of a black rice extract (Oryza sativa L. indica) on cholesterol levels and plasma lipid parameters in Wistar Kyoto rats. J Funct Foods 1:50-56 https://doi.org/10.1016/j.jff.2008.09.008
  78. Zhuo Q, Wang Z, Fu P, Piao J, Tian Y, Xu J, Yang X. 2009. Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities. Diabetes Res Clin Pract 84:27-33 https://doi.org/10.1016/j.diabres.2008.12.019

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