Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Langerhans cell histiocytosis of the mandible: two case reports and literature review

  • Hwang, Dae-Seok (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Lee, Jun Sang (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Uk-Kyu (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Park, Hae Ryoun (Department of Translational Dental Science, School of Dentistry, Pusan National University) ;
  • Ryu, Mi Heon (Department of Translational Dental Science, School of Dentistry, Pusan National University) ;
  • Lee, Ji Hye (Department of Translational Dental Science, School of Dentistry, Pusan National University) ;
  • Jung, Yun-Hoa (Department of Translational Dental Science, School of Dentistry, Pusan National University) ;
  • Kim, Gyoo Cheon (Department of Translational Dental Science, School of Dentistry, Pusan National University)
  • Received : 2018.05.04
  • Accepted : 2018.06.20
  • Published : 2019.06.30
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Abstract

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the proliferation of dendritic cells resulting in local or systemic symptoms. The clinical symptoms of patients with Langerhans cell histiocytosis depend on the site and the degree of involvement. This article describes two case histories of unifocal bony Langerhans cell histiocytosis with mandibular involvement and further discusses the appropriate management of such via a review of the literature.

Keywords

References

  1. Favara BE, Feller AC, Pauli M, Jaffe ES, Weiss LM, Arico M, et al. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol 1997;29:157-66. https://doi.org/10.1002/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C
  2. Grois N, Potschger U, Prosch H, Minkov M, Arico M, Braier J, et al. Risk factors for diabetes insipidus in langerhans cell histiocytosis. Pediatr Blood Cancer 2006;46:228-33. https://doi.org/10.1002/pbc.20425
  3. Hartman KS. Histiocytosis X: a review of 114 cases with oral involvement. Oral Surg Oral Med Oral Pathol 1980;49:38-54. https://doi.org/10.1016/0030-4220(80)90030-4
  4. Ardekian L, Peled M, Rosen D, Rachmiel A, Abu el-Naaj I, Laufer D. Clinical and radiographic features of eosinophilic granuloma in the jaws: review of 41 lesions treated by surgery and low-dose radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:238-42. https://doi.org/10.1016/S1079-2104(99)70279-9
  5. Guiglia R, Pizzo G, Arico M, Maresi E, Compilato D, Campisi G. Bifocal manifestation of eosinophilic granuloma in a pediatric patient. Med Sci Monit 2009;15:CS95-9.
  6. Dagenais M, Pharoah MJ, Sikorski PA. The radiographic characteristics of histiocytosis X. A study of 29 cases that involve the jaws. Oral Surg Oral Med Oral Pathol 1992;74:230-6. https://doi.org/10.1016/0030-4220(92)90388-7
  7. Kim BE, Koh KN, Suh JK, Im HJ, Song JS, Lee JW, et al.; Korea Histiocytosis Working Party. Clinical features and treatment outcomes of Langerhans cell histiocytosis: a nationwide survey from Korea Histiocytosis Working Party. J Pediatr Hematol Oncol 2014;36:125-33. https://doi.org/10.1097/MPH.0000000000000054
  8. Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, et al. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood 2010;116:1919-23. https://doi.org/10.1182/blood-2010-04-279083
  9. Yasko AW, Fanning CV, Ayala AG, Carrasco CH, Murray JA. Percutaneous techniques for the diagnosis and treatment of localized Langerhans-cell histiocytosis (eosinophilic granuloma of bone). J Bone Joint Surg Am 1998;80:219-28. https://doi.org/10.2106/00004623-199802000-00009
  10. Karagoz Guzey F, Bas NS, Emel E, Alatas I, Kebudi R. Polyostotic monosystemic calvarial and spinal langerhans' cell histiocytosis treated by surgery and chemotherapy. Pediatr Neurosurg 2003;38:206-11. https://doi.org/10.1159/000069100
  11. Gadner H, Minkov M, Grois N, Potschger U, Thiem E, Arico M, et al. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood 2013;121:5006-14. https://doi.org/10.1182/blood-2012-09-455774
  12. Haupt R, Minkov M, Astigarraga I, Schafer E, Nanduri V, Jubran R, et al.; Euro Histio Network. Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer 2013;60:175-84. https://doi.org/10.1002/pbc.24367

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