Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Enhanced Antioxidant and Anticancer Properties of Processed Eucommiae Cortex

  • Yoon, Hye Ji (Department of Natural Medicine Resources, Semyung University) ;
  • Park, So Hyeon (Department of Natural Medicine Resources, Semyung University) ;
  • Lee, Hwa Jin (Department of Natural Medicine Resources, Semyung University)
  • Received : 2018.08.15
  • Accepted : 2018.12.14
  • Published : 2019.06.30
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Abstract

Eucommiae Cortex (EC), bark of Eucommia ulmoides, has been known as a traditional medicine to regulate hypertension and immune system. Because silk of gum in the EC blocks the release of active ingredients, EC generally has been utilized after processing with carbonization or salt-water to breakdown it. This study aimed to investigate the differences of non-processed EC and processed EC on antioxidant and anticancer properties. Antioxidant capacity was assessed by measuring the content of total polyphenols, reducing power, and ABTS radical scavenging effect. And anticancer effects were examined by evaluating the viability of pancreatic cancer cells and wound healing ability. The results demonstrated that processed EC contained more content of polyphenols and exhibited more potent reducing power and radical scavenging effect than non-processed EC. In addition, processed EC more efficiently inhibited proliferation and migration of pancreatic cancer cells. These results suggest that processing of medicinal plants can improve the biological properties such as antioxidant or anticancer activity, which may lead to the development of herbal medicine treatment technology.

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References

  1. Dai, X.; Huang, Q.; Zhou, B.; Gong, Z.; Liu, Z.; Shi, S. Food Chem. 2013, 139, 563-570. https://doi.org/10.1016/j.foodchem.2013.02.006
  2. Hsieh, C. L.; Yen, G. C. Life Sci. 2000, 66, 1387-1400. https://doi.org/10.1016/S0024-3205(00)00450-1
  3. Lang, C.; Liu, Z.; Taylor, H. W.; Baker, D. G. Am. J. Chin. Med. 2005, 33, 215-230. https://doi.org/10.1142/S0192415X05002795
  4. Choi, Y. H.; Seo, J. H.; Kim, J. S.; Heor, J. H.; Kim, S. K.; Choi, S. U.; Kim, Y. S.; Kim, Y. K.; Ryu, S. Y. Kor. J. Pharmacogn. 2003, 34, 308-313.
  5. Kim, M. C.; Kim, D. S.; Kim, S. J.; Park, J.; Kim, H. L.; Kim, S. Y.; Ahn, K. S.; Jang, H. J.; Lee, S. G.; Lee, K. M.; Hong, S. H.; Um, J. Y. Am. J. Chin. Med. 2012, 40, 135-149. https://doi.org/10.1142/S0192415X12500115
  6. Hirata, T.; Kobayashi, T.; Wada, A.; Ueda, T.; Fujikawa, T.; Miyashita, H.; Ikeda, T.; Tsukamoto, S.; Nohara, T. Bioorg. Med. Chem. Lett. 2011, 21, 1786-1791. https://doi.org/10.1016/j.bmcl.2011.01.060
  7. Zhang, R.; Liu, Z. G.; Li, C.; Hu, S. J.; Liu, L.; Wang, J. P.; Mei, Q. B. Bone 2009, 45, 553-559. https://doi.org/10.1016/j.bone.2008.08.127
  8. He, X.; Wang, J.; Li, M.; Hao, D.; Yang, Y.; Zhang, C.; He, R.; Tao, R. J. Ethnopharmacol. 2014, 151, 78-92. https://doi.org/10.1016/j.jep.2013.11.023
  9. Chai, X.; Wang, Y.; Su, Y.; Bah, A. J.; Hu, L.; Gao, Y.; Gao, X. J. Pharm. Biomed. Anal. 2012, 57, 52-61. https://doi.org/10.1016/j.jpba.2011.08.023
  10. Seo, C. S.; Kim, J. H.; Shin, H. K.; Kim, B. S. Kor. J. Pharmacogn. 2015, 46, 123-132.
  11. Singleton, V. L.; Rossi, J. A. Am. J. Enol. Vitic. 1965, 16, 144-158.
  12. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Free Radic. Biol. Med. 1999, 26, 1231-1237. https://doi.org/10.1016/S0891-5849(98)00315-3
  13. Oyaizu, M. Jpn. J. Nutr. 1986, 44, 307-315. https://doi.org/10.5264/eiyogakuzashi.44.307
  14. Chen, X. Y.; Luo, L. I.; Ren, G. C.; Qu, G. Y.; Dong, L. S. West China Journal of Pharmaceutical Sciences 2008, 5, 592-593.
  15. Tao, Y.; Sheng, C.; Li, W. D.; Cai, B. C.; Lu, T. L. Zhongguo Zhong Yao Za Zhi 2014, 39, 4352-4355.
  16. Yen, G. C.; Hsieh, C. L. J. Agric. Food Chem. 1998, 46, 3952-3957. https://doi.org/10.1021/jf9800458
  17. Hu, W.; Wang, G.; Li, P.; Wang, Y.; Si, C. L.; He, J.; Long, W.; Bai, Y.; Feng, Z.; Wang, X. Chem. Biol. Interact. 2014, 224, 108-116. https://doi.org/10.1016/j.cbi.2014.10.011
  18. Milkovic, L.; Siems, W.; Siems, R.; Zarkovic, N. Curr. Pharm. Des. 2014, 20, 6529-6542. https://doi.org/10.2174/1381612820666140826152822
  19. Talero, E.; Avila-Roman, J.; Motilva, V. Curr. Pharm. Des. 2012, 18, 3939-3965. https://doi.org/10.2174/138161212802083725
  20. Zhu, Y.; Hao, W.; Li, X. Zhongguo Zhong Yao Za Zhi 1997, 22, 598-601.
  21. Wells, A.; Grahovac, J.; Wheeler, S.; Ma, B.; Lauffenburger, D. Trends Pharmacol. Sci. 2013, 34, 283-289. https://doi.org/10.1016/j.tips.2013.03.001
  22. Li, Y.; Han, C.; Wang, J.; Xiao, W.; Wang, Z.; Zhang, J.; Yang, Y.; Zhang, S.; Ai, C. J. Ethnopharmacol. 2014, 151, 452-460. https://doi.org/10.1016/j.jep.2013.10.067
  23. Riaz, A.; Rasul, A.; Hussain, G.; Zahoor, M. K.; Jabeen, F.; Subhani, Z.; Younis, T.; Ali, M.; Sarfraz, I.; Selamoglu, Z. Adv. Pharmacol. Sci. 2018, 2018, 9794625. https://doi.org/10.1155/2018/9794625
  24. Soromou, L. W.; Chen, N.; Jiang, L.; Huo, M.; Wei, M.; Chu, X.; Millimouno, F. M.; Feng, H.; Sidime, Y.; Deng, X. Biochem. Biophys. Res. Commun. 2012, 419, 256-261. https://doi.org/10.1016/j.bbrc.2012.02.005
  25. Cho, I. H.; Gong, J. H.; Kang, M. K.; Lee, E. J.; Park, J. H.; Park, S. J.; Kang, Y. H. BMC Pulm. Med. 2014, 14, 122. https://doi.org/10.1186/1471-2466-14-122
  26. Chen, M.; Cai, F.; Zha, D.; Wang, X.; Zhang, W.; He, Y.; Huang, Q.; Zhuang, H.; Hua, Z. C. Oncotarget 2017, 8, 26941-26958. https://doi.org/10.18632/oncotarget.15264
  27. Choi, S.; Ko, H. C.; Ko, S. Y.; Hwang, J. H.; Park, J. G.; Kang, S. H.; Han, S. H.; Yun, S. H.; Kim, S. J. Biol. Pharm. Bull. 2007, 30, 772-778. https://doi.org/10.1248/bpb.30.772
  28. Chen, Q. C.; Zhang, W. Y.; Jin, W.; Lee, I. S.; Min, B. S.; Jung, H. J.; Na, M.; Lee, S.; Bae, K. Planta Med. 2010, 76, 79-81. https://doi.org/10.1055/s-0029-1185944
  29. Ganeshpurkar, A.; Saluja, A. K. Saudi Pharm. J. 2017, 25, 149-164. https://doi.org/10.1016/j.jsps.2016.04.025
  30. Lin, J. P.; Yang, J. S.; Lu, C. C.; Chiang, J. H.; Wu, C. L.; Lin, J. J.; Lin, H. L.; Yang, M. D.; Liu, K. C.; Chiu, T. H.; Chung, J. G. Leuk. Res. 2009, 33, 823-828. https://doi.org/10.1016/j.leukres.2008.09.032
  31. Chen, H.; Miao, Q.; Geng, M.; Liu, J.; Hu, Y.; Tian, L.; Pan, J.; Yang, Y. Scientific World Journal 2013, 2013, 269165.
  32. Araujo, J. R.; Goncalves, P.; Martel, F. Nutr. Res. 2011, 31, 77-87. https://doi.org/10.1016/j.nutres.2011.01.006