DOI QR코드

DOI QR Code

Is Cross-reactivity with Nontuberculous Mycobacteria a Systematic Problem in the Xpert MTB/RIF Assay?

  • Huh, Hee Jae (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Song, Dong Joon (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Ki, Chang-Seok (Green Cross Genome) ;
  • Lee, Nam Yong (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2018.09.15
  • Accepted : 2018.10.23
  • Published : 2019.01.31

Abstract

Keywords

References

  1. Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N. Xpert(R) MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev 2014;(1):CD009593.
  2. Jeon D. WHO treatment guidelines for drug-resistant tuberculosis, 2016 update: applicability in South Korea. Tuberc Respir Dis 2017;80:336-43. https://doi.org/10.4046/trd.2017.0049
  3. Huh HJ, Jeong BH, Jeon K, Koh WJ, Ki CS, Lee NY. Performance evaluation of the Xpert MTB/RIF assay according to its clinical application. BMC Infect Dis 2014;14:589. https://doi.org/10.1186/s12879-014-0589-x
  4. Marlowe EM, Novak-Weekley SM, Cumpio J, Sharp SE, Momeny MA, Babst A, et al. Evaluation of the Cepheid Xpert MTB/RIF assay for direct detection of Mycobacterium tuberculosis complex in respiratory specimens. J Clin Microbiol 2011;49:1621-3. https://doi.org/10.1128/JCM.02214-10
  5. Pang Y, Lu J, Su B, Zheng H, Zhao Y. Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay. Infection 2017;45:677-81. https://doi.org/10.1007/s15010-017-1044-x
  6. Ryu YJ, Koh WJ, Daley CL. Diagnosis and treatment of nontuberculous mycobacterial lung disease: clinicians' perspectives. Tuberc Respir Dis 2016;79:74-84. https://doi.org/10.4046/trd.2016.79.2.74
  7. Pang Y, Tan Y, Chen J, Li Y, Zheng H, Song Y, et al. Diversity of nontuberculous mycobacteria in eastern and southern China: a cross-sectional study. Eur Respir J 2017;49:1601429. https://doi.org/10.1183/13993003.01429-2016
  8. Koh WJ, Jeong BH, Kim SY, Jeon K, Park KU, Jhun BW, et al. Mycobacterial characteristics and treatment outcomes in Mycobacterium abscessus lung disease. Clin Infect Dis 2017;64:309-16. https://doi.org/10.1093/cid/ciw724
  9. Greendyke R, Byrd TF. Differential antibiotic susceptibility of Mycobacterium abscessus variants in biofilms and macrophages compared to that of planktonic bacteria. Antimicrob Agents Chemother 2008;52:2019-26. https://doi.org/10.1128/AAC.00986-07
  10. Cepheid. Xpert MTB/RIF assay, 301-1404 Rev. B [package insert]. Sunnyvale: Cepheid; 2015.

Cited by

  1. Diagnosis of Osteoarticular Tuberculosis: Perceptions, Protocols, Practices, and Priorities in the Endemic and Non-Endemic Areas of the World—A WAIOT View vol.8, pp.9, 2019, https://doi.org/10.3390/microorganisms8091312
  2. Non-Tuberculous Mycobacteria: Molecular and Physiological Bases of Virulence and Adaptation to Ecological Niches vol.8, pp.9, 2019, https://doi.org/10.3390/microorganisms8091380