Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Superficial malignant peripheral nerve sheath tumor from recurrent neurofibroma in the abdominal wall of a patient without neurofibromatosis type 1

  • Jung, Chang Yeon (Department of Surgery, Yeungnam University College of Medicine) ;
  • Bae, Jung Min (Department of Surgery, Yeungnam University College of Medicine) ;
  • Choi, Joon Hyuk (Department of Pathology, Yeungnam University College of Medicine) ;
  • Jung, Ki Hoon (Department of Surgery, Dongguk University College of Medicine)
  • Received : 2018.06.19
  • Accepted : 2018.09.12
  • Published : 2019.01.31
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Abstract

Malignant peripheral nerve sheath tumor (MPNST) is rare, accounting for 5-10% of all soft tissue sarcomas. MPNST is characteristically aggressive and has a poor prognosis. Fifty percent of patients with MPNST have neurofibromatosis type 1 (NF1). NF-associated MPNST occurs more often at younger ages than sporadic MPNST, but the survival difference is controversial. Superficial MPNST from a recurrent neurofibroma is extremely rare and only a limited number of cases have been reported in the literature. Herein, we report an unusual case of superficial MPNST from a recurrent neurofibroma in a patient without NF1.

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References

  1. Hwang IK, Hahn SM, Kim HS, Kim SK, Kim HS, Shin KH, et al. Outcomes of treatment for malignant peripheral nerve sheath tumors: different clinical features associated with neurofibromatosis type 1. Cancer Res Treat 2017;49:717-26. https://doi.org/10.4143/crt.2016.271
  2. Farid M, Demicco EG, Garcia R, Ahn L, Merola PR, Cioffi A, et al. Malignant peripheral nerve sheath tumors. Oncologist 2014;19:193-201. https://doi.org/10.1634/theoncologist.2013-0328
  3. Kim CH. An unusual case of a malignant peripheral nerve sheath tumor. Arch Plast Surg 2013;40:285-7. https://doi.org/10.5999/aps.2013.40.3.285
  4. Chen HJ, Chen HS, Chang YL, Wu YY. Malignant peripheral nerve sheath tumor of the neck: transformation from a recurrent neurofibroma in a patient without neurofibromatosis. Tzu Chi Med J 2010;22:195-9. https://doi.org/10.1016/S1016-3190(10)60071-7
  5. Kwon Y, Lee SE, Hwang DW, Lim CS, Jang JY, Kim SW. Malignant peripheral nerve sheath tumor of the pancreas: a case report. Korean J Hepatobiliary Pancreat Surg 2008;12:307-11.
  6. Zhang M, Wang Y, Jones S, Sausen M, McMahon K, Sharma R, et al. Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nat Genet 2014;46:1170-2. https://doi.org/10.1038/ng.3116
  7. Schaefer IM, Fletcher CD. Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse-type neurofibroma: clinicopathologic characterization in a series of 9 cases. Am J Surg Pathol 2015;39:1234-41. https://doi.org/10.1097/PAS.0000000000000447
  8. Allison KH, Patel RM, Goldblum JR, Rubin BP. Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis. Am J Clin Pathol 2005;124:685-92. https://doi.org/10.1309/V8XMK5R78Q96V090
  9. Feng CJ, Ma H, Liao WC. Superficial or cutaneous malignant peripheral nerve sheath tumor-clinical experience at Taipei Veterans General Hospital. Ann Plast Surg 2015;74(Suppl 2):S85-8. https://doi.org/10.1097/SAP.0000000000000465
  10. Thomas C, Somani N, Owen LG, Malone JC, Billings SD. Cutaneous malignant peripheral nerve sheath tumors. J Cutan Pathol 2009;36:896-900. https://doi.org/10.1111/j.1600-0560.2008.01151.x
  11. Njoumi N, Elabsi M, Attolou G, Elouazzani H, Elalami FH, Chkoff MR. Solitary preperitoneal neurofibroma: a case report. BMC Res Notes 2015;8:115. https://doi.org/10.1186/s13104-015-1098-8
  12. Azani AB, Bishop JA, Thompson LD. Sinonasal tract neurofibroma: a clinicopathologic series of 12 cases with a review of the literature. Head Neck Pathol 2015;9:323-33. https://doi.org/10.1007/s12105-014-0593-x
  13. Boto J, Boudabbous S, Lobrinus JA, Gourmaud J, Terraz S. Solitary neurofibroma of the spermatic cord: a case report. J Radiol Case Rep 2015;9:19-28.
  14. Schaefer IM, Fletcher CD, Hornick JL. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. Mod Pathol 2016;29:4-13. https://doi.org/10.1038/modpathol.2015.134
  15. Kang Y, Pekmezci M, Folpe AL, Ersen A, Horvai AE. Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma. Mod Pathol 2014;27:55-61. https://doi.org/10.1038/modpathol.2013.115
  16. Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, et al. Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol 2015;28:187-200. https://doi.org/10.1038/modpathol.2014.109