Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
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Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene

  • Choi, Ah-rum (Institute of Occupational and Environmental Health, Korean Industrial Heath Association) ;
  • Im, Sung-guk (Institute of Occupational and Environmental Health, Korean Industrial Heath Association) ;
  • Lee, Mi-young (Occupational Safety and Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Lee, Se-Hoon (Seoul Occupational Health Center, Korean Industrial Heath Association)
  • Received : 2017.05.30
  • Accepted : 2018.07.17
  • Published : 2019.03.30
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Abstract

Background: This study was designed to provide logical backgrounds for the revision of biological exposure indices (BEIs) for styrene exposure in Korea. In order to investigate the correlation between airborne styrene and biological exposure indices, we measured urinary mandelic acid (MA) and phenylglyoxylic acid (PGA) in workers exposed to styrene occupationally, as well as airborne styrene at workplaces. Methods: Surveys were conducted for 56 subjects. The concentrations of airborne styrene and urinary metabolites of styrene were measured in 36 workers who were occupationally exposed to styrene, and in 20 controls. Air samples were collected using personal air samplers and analyzed by gas chromatography. Urine samples were collected at the end of the shift and analyzed by high performance liquid chromatography. Results: The geometric mean concentration of airborne styrene was 9.6 ppm. The concentrations of urinary MA, PGA, and MA+PGA in the exposure group were 267.7, 143.3, and 416.8 mg/g creatinine, respectively. The correlation coefficients for correlation between airborne styrene and MA, PGA, and MA+PGA were 0.714, 0.604, and 0.769, respectively. The sum of urinary MA and PGA corresponding to an exposure of 20 ppm styrene was 603 mg/g creatinine. Conclusion: The correlation of the sum of urinary MA and PGA with airborne styrene was better than the correlation of each individual urinary determinant. It is considered appropriate to amend the concentration of urinary MA+PGA to 600 mg/g creatinine as a BEI, which corresponds to an airborne styrene concentration of 20 ppm in Korea.

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References

  1. Chung HK, Kang SK, Yang JS, Kim KW, Lee JS, Cho YS, et al. Styrene in air and blood and mandelic acid in urine in the workers exposed to styrene. Kor J Occup Med 1994;6:113-21 [in Korean]. https://doi.org/10.35371/kjoem.1994.6.1.113
  2. Cho HY, Cho SH, Kim EA, Kim BG, Park SH, Kang SK. A survey on the status of using styrene in Korea. J Korean Soc Occup Environ Hyg 2008;18:310-7 [in Korean].
  3. Ministry of Environment. The chemical circulation increased by 3.5% (compared to 2006) to 4.3 billion tons in 2010, vol. 7; 2012. 4: 11 p. [in Korean].
  4. Ministry of Environment. Survey on pollutant release in 2001. Seoul (Korea): Ministry of Environment; 2003. 5 p. [in Korean].
  5. Ministry of Environment. Survey on pollutant release in 2010. Seoul (Korea): Ministry of Environment; 2012. 10 p. [in Korean].
  6. Brooks SM, Anderson L, Emmett E, Carson A, Tsay JY, Elia V, et al. The effect of protective equipment on styrene exposure in workers in the reinforced plastic industry. Arch Environ Health 1980;35:287-94. https://doi.org/10.1080/00039896.1980.10667507
  7. Crandall MS. Worker exposure to styrene monomer in the reinforced plastic boat-making industry. Am Ind Hyg Assoc J 1981;42:499-502. https://doi.org/10.1080/15298668191420143
  8. Schumacher RL, Breysse PA, Carlyon WR, Hibbard RP. Styrene exposure in the fiberglass fabrication industry in Washington State. Am Ind Hyg Assoc J 1981;42:143-9. https://doi.org/10.1080/15298668191419488
  9. Ikeda M, Koizumi A, Miyasaka M, Watanabe T. Styrene exposure and biologic monitoring in FRP production plant. Int Arch Occup Environ Health 1982;49:325-39. https://doi.org/10.1007/BF00377941
  10. Okun AH, Beaumont JJ, Meinhardt TJ, Crandall MS. Mortality patterns among styrene-exposed boat builders. Am J Ind Med 1985;8:193-205. https://doi.org/10.1002/ajim.4700080305
  11. Lemasters GK, Carson A, Samuels SJ. Occupational styrene exposure for twelve product categories in the reinforced plastic industry. Am Ind Hyg Assoc J 1985;46:434-41. https://doi.org/10.1080/15298668591395120
  12. Tranfo G, Gherardi M, Paci E, Gatto M, Gordiani A, Caporossi L, et al. Occupational exposure to styrene in the fibreglass reinforced plastic industry: comparison between two different manufacturing processes. Med Lav 2012;103:402-12.
  13. Dutkiewicz T, Tyras H. Skin absorption of toluene, styrene and xylene by man. Br J Ind Med 1968;25:243.
  14. Astrand I. Uptake of solvents in blood and tissues of man. A review. Scand J Work Environ Health 1975;1:199-218. https://doi.org/10.5271/sjweh.2845
  15. Berode M, Droz PO, Guillemin M. Human exposure to styrene: VI. Percutaneous absorption in human volunteers. Int Arch Occup Environ Health 1985;55:331-6. https://doi.org/10.1007/BF00377691
  16. Frieden TR. Toxicological profile for styrene. Agency for Toxic Substances and Disease Registry (ATSDR); 2010. 283 p.
  17. American Conference of Governmental Industrial Hygienists. Styrene, documentation of the threshold limit values and biological exposure indices. 7th ed.; 2011. Cincinnati.
  18. Guillemin MP, Bauer D. Biological monitoring of exposure to styrene by analysis of combined urinary mandelic and phenylglyoxylic acids. Am Ind Hyg Assoc J 1978;39:873-9. https://doi.org/10.1080/0002889778507877
  19. Ong CN, Shi CY, Chia SE, Chua SC, Ong HY, Lee BL, et al. Biological monitoring of exposure to low concentrations of styrene. Am J Ind Med 1994;25:719-30. https://doi.org/10.1002/ajim.4700250511
  20. Ahn KD, Ki YH, Ki YS, Lee SK, Lee SS, Kim HS. Standard of biological exposure indices and analytical method I. Incheon (Korea): Occupational Safety and Health Research Institute; 2010. p. 188-9. Report No.: OSHRI 2010-64-880. [in Korean].
  21. Korean Occupational Safety and Health Agency. KOSHA guide H-151-2016; 2016. 9 p [in Korean].
  22. Korean Occupational Safety and Health Agency. KOSHA guide A-70-2012; 2012. p. 9-12 [in Korean].
  23. National Institute for Occupational Safety and Health. NIOSH Manual of analytical methods. 4th ed.; 2003. Method 1501.
  24. Bartolucci GB, Derosa E, Gori GP, Chiesura Corona P, Perbellini L, Brugnone F. Biomonitoring of occupational exposure to styrene. Appl Ind Hyg 1986;1:125-31. https://doi.org/10.1080/08828032.1986.10390495
  25. HO MH, Dillon HK. Biological monitoring of exposure to Chemicals. New York: A Wiley-interscience publication; 1987. p. 155-68.
  26. Lee CH, Moon DH, Lee H, Park JH, Kim DH, Lee JT, et al. Urinary metabolites and neurobehavioral test on styrene exposure workers. Korean J Prev Med 1996;29:863-76 [in Korean].
  27. Oh SU, Won JI. A study on the urinary metabolites of styrene exposed workers. Korean J Sanitation 1996;11:1-7 [in Korean].
  28. Prieto MJ, Marhuenda D, Cardona A. Analysis of styrene and its metabolites in blood and urine of workers exposed to both styrene and acetone. J Anal Toxicol 2002;26:23-8. https://doi.org/10.1093/jat/26.1.23
  29. Occupational Safety and Health Research Institute. Worker's health examination practice guidelines. 3rd. Incheon (Korea): Occupational Safety and Health Research Institute; 2013. p. 181-2. Report No.: 2013-Research Institute-1466. [in Korean].
  30. Triebig G, Schaller KH. Addendum to styrene, BAT value documentation. Wiley-VCH Verlag GmbH & Co. KGaA; 2010.
  31. Guillemin MP, Bauer D, Martin B, Marazzi A. Human exposure to styrene. IV. Industrial hygiene investigations and biological monitoring in the polyester industry. Int Arch Occup Environ Health 1982;51:139-50. https://doi.org/10.1007/BF00378158
  32. Droz PO, Guillemin MP. Human styrene exposure. V. Development of a model for biological monitoring. Int Arch Occup Environ Health 1983;53:19-36. https://doi.org/10.1007/BF00406174
  33. Haufroid V, Buchet JP, Gardinal S, Ghittori S, Imbriani M, Hirvonen A, et al. Importance of genetic polymorphisms of drug metabolizing enzymes for the interpretation of biomarkers of exposure to styrene. Biomarkers 2001;6:236-49. https://doi.org/10.1080/13547500010014540
  34. Wilson HK, Robertson SM, Waldron HA, Gompertz D. Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour. Br J Ind Med 1983;40:75-80.
  35. Lee KJ, Park JB, Lee KW, Lim KJ, Jang KY, Bang CW. Relationship between phenylglyoxylic acid in urine and postural body sway in styrene exposed workers. Korean J Occup Environ Med 2002;14:459-67 [in Korean]. https://doi.org/10.35371/kjoem.2002.14.4.459
  36. Cherry N, Gautrin D. Neurotoxic effects of styrene: further evidence. Br J Ind Med 1990;47:29-37.
  37. Shi CY, Chua SC, Lee BL, Ong HY, Jeyaratam J, Ong CN. Kinetics of styrene urinary metabolites: a study in a low-level occupational exposure setting in Singapore. Int Arch Occup Environ Health 1994;65:319-23. https://doi.org/10.1007/BF00405696
  38. Bonanni R, Gatto M, Paci E, Gordiani A, Gherardi M, Tranfo G. Biomonitoring for exposure assessment to styrene in the fibreglass reinforced plastic industry: determinants and interferents. Ann Occup Hyg 2015;59:1000-11. https://doi.org/10.1093/annhyg/mev047

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