Neonatal Medicine

The Korean Society of Neonatology (대한신생아학회)
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Bilateral Acute Retinal Necrosis and Encephalomalacia Due to Herpes Simplex Virus Infection in a Premature Infant

  • Bae, Mi Hye (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute) ;
  • Lee, Na Rae (Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine) ;
  • Han, Young Mi (Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine) ;
  • Yoon, Lira (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute) ;
  • Kim, Young Mi (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute) ;
  • Byun, Shin Yun (Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine) ;
  • Lee, Jae Jung (Department of Ophthalmology, Pusan National University School of Medicine) ;
  • Kwon, Han Jo (Biomedical Research Institute, Pusan National University Hospital) ;
  • Kwak, Min Jung (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute) ;
  • Park, Kyung Hee (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute)
  • Received : 2018.08.10
  • Accepted : 2018.11.29
  • Published : 2019.02.28
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Abstract

Herpes simplex virus (HSV) is a common pathogen, that causes a broad spectrum of diseases, ranging from minor skin infections to severe encephalitis and widespread infections. Acute retinal necrosis (ARN), one of the most serious manifestations of HSV infection, is defined as a rapidly progressing necrotizing retinopathy that presents discrete areas of circumferential retinal necrosis, along with signs of uveitis, vitreitis, and retinal vasculitis. We encountered a case of a female infant, born at 33 weeks of gestation with a body weight at birth of 2,080 g, who had ARN and encephalomalacia due to HSV infection. ARN associated with HSV infection should be suspected when nonspecific retinal exudates are observed in neonates, especially preterm infants.

Keywords

Acknowledgement

This work was supported by a clinical research grant from Pusan National University Hospital 2017.

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