Journal of Medicine and Life Science

Institute for Medical Science (제주대학교 의과학연구소)
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Effect and mechanism of docosahexaenoic acid on the proliferation of dermal papilla cells

Docosahexaenoic acid의 모유두세포 증식 효능 및 기전

  • Ko, Jiyeon (Department of Medicine, School of Medicine, Jeju National University) ;
  • Oh, Il-Joong (Department of Medicine, School of Medicine, Jeju National University) ;
  • Kang, Jung-Il (Department of Medicine, School of Medicine, Jeju National University) ;
  • Choi, Youn Kyung (Department of Medicine, School of Medicine, Jeju National University) ;
  • Yoon, Hoon-Seok (Department of Medicine, School of Medicine, Jeju National University) ;
  • Yoo, Eun-Sook (Department of Medicine, School of Medicine, Jeju National University) ;
  • Ko, Chang-Ik (Choung Ryong Fisheries Co. Ltd.) ;
  • Ahn, Yong-Seok (Choung Ryong Fisheries Co. Ltd.)
  • 고지연 (제주대학교 의학전문대학원 의학과) ;
  • 오일중 (제주대학교 의학전문대학원 의학과) ;
  • 강정일 (제주대학교 의학전문대학원 의학과) ;
  • 최윤경 (제주대학교 의학전문대학원 의학과) ;
  • 윤훈석 (제주대학교 의학전문대학원 의학과) ;
  • 유은숙 (제주대학교 의학전문대학원 의학과) ;
  • 고창익 (주식회사 청룡수산 연구소) ;
  • 안용석 (주식회사 청룡수산 연구소)
  • Received : 2019.10.24
  • Accepted : 2019.11.13
  • Published : 2019.12.31
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Abstract

Docosahexaenoic acid (DHA), a principal of mackerel-derived fermented fish oil, increases the proliferation of dermal papilla cells (DPCs) via the upregulation of cell cycle-associated proteins such as cyclin D1 and cdc2 p34, and might promote hair-growth. However, the intracellular mechanisms that underlie the action of DHA in the proliferation of DPCs have not been investigated fully. In this study, we addressed the action mechanisms of DHA to trigger the activation of anagen in DPCs. DHA activated β-catenin signaling by the increased phosphorylation at serine 552 and serine 675 as well as the translocation and accumulation of activated β-catenin into the nucleus. In the other hand, DHA inhibited canonical TGF-β/Smad signaling by the decreased phosphorylation of Smad2/3. Taken together, the results indicate that DHA might stimulate anagen signaling via the activation of Wnt/β-catenin pathway, while the inactivation of canonical TGF-β signaling pathway in DPCs.

Keywords

References

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