Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Brachial Artery Thrombosis in an 8-year-old Boy with Antiphospholipid Antibodies Induced by Mycoplasma pneumoniae Infection: a Case Report

  • Woo, Jung Hee (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Kwon, Jung Hyun (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Je, Bo-Kyung (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Shin, Jae Seoung (Department of Thoracic and Cardiovascular Surgery, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Seo, Won Hee (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Jang, Gi Young (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine)
  • Received : 2018.09.04
  • Accepted : 2018.12.09
  • Published : 2019.04.25
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Abstract

Antiphospholipid antibodies may be produced in cases involving autoimmune diseases and can sometimes be caused by infections, such as Mycoplasma pneumoniae infection. However, antiphospholipid antibodies causing thrombosis associated with M. pneumoniae pneumonia in children have rarely been reported. We report a case of an 8-year-old boy with M. pneumoniae pneumonia with antiphospholipid antibodies, complicated by brachial artery thrombosis. He was found to have antiphospholipid antibodies and low protein S levels. The brachial artery thrombus was removed via thrombectomy. The titers of antiphospholipid antibodies turned normal within 5 months. This is a rare case of M. pneumoniae infection with brachial artery thrombosis associated with transient antiphospholipid antibodies.

항인지질항체는 자가면역 질환에서 발생할 수 있고, 때로는 마이코플라즈마와 같은 감염 후에도 발생할 수 있다. 그러나 마이코플라즈마 폐렴 후 항인지질항체의 발현과 혈전의 발생은 매우 드물게 보고되어왔다. 본 8세 환아는 마이코플라즈마 폐렴 입원 치료 중 손가락의 변색 및 감각 저하가 발생하였고 혈액검사 결과 항인지질항체 양성으로 확인되었다. 이로 인해 상완동맥 혈전증이 발생하여 혈전제거술을 시행하여 제거하였다. 양성이었던 항인지질항체는 5개월 내 다시 정상화되었다. 마이코플라즈마 폐렴의 합병증은 피부 병변을 포함하여 체내 많은 장기에 다양한 증상을 보이지만, 그 중 항인지질항체의 발현으로 인한 혈전의 발생은 치명적이므로, 마이코플라즈마 폐렴의 치료에 있어 고려해야 할 합병증의 사례를 보고한다.

Keywords

References

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