Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Clinical Features of Staphylococcal Scalded Skin Syndrome Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus in Changwon City, Korea, during 2006 and 2015

2006년부터 2015년까지 창원 지역에서 발생한 지역사회관련 메티실린내성 황색포도알균에 의한 포도알균 열상 피부증후군의 임상양상

  • Park, Jun Hyeong (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Min Chae (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kang, Jin Han (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Choi, Jae Won (Department of Pediatrics, Changwon Fatima Hospital) ;
  • Lee, Hak Sung (Department of Pediatrics, Changwon Fatima Hospital) ;
  • Shin, Ju Hwa (Department of Pediatrics, Changwon Fatima Hospital) ;
  • Lee, Je Chul (Department of Microbiology, Kyungpook National University School of Medicine) ;
  • Ma, Sang Hyuk (Department of Pediatrics, Changwon Fatima Hospital)
  • 박준형 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김민채 (가톨릭대학교 의과대학 소아과학교실) ;
  • 강진한 (가톨릭대학교 의과대학 소아과학교실) ;
  • 최재원 (창원파티마병원 소아과학교실) ;
  • 이학성 (창원파티마병원 소아과학교실) ;
  • 신주화 (창원파티마병원 소아과학교실) ;
  • 이제철 (경북대학교 의과대학 미생물학교실) ;
  • 마상혁 (창원파티마병원 소아과학교실)
  • Received : 2016.10.01
  • Accepted : 2016.10.27
  • Published : 2019.04.25
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Abstract

Purpose: We investigated the clinical features and epidemiology of staphylococcal scalded skin syndrome (SSSS) from year 2006 to 2015 in Changwon city, Korea. Methods: We reviewed medical records of 69 patients diagnosed with SSSS from year 2006 to 2015. Antibiotic susceptibility testing was performed by agar dilution method. Methicillinresistant Staphylococcus aureus (MRSA) was phenotypically identified by oxacillin susceptibility testing and genotypically confirmed by the existence of the mecA gene. Results: The median age of patients was 2.0 years (range 0.2-6 years). Three (4.3%), 53 (76.8%), and 13 (18.9%) patients showed the generalized type, the intermediate type, and the abortive type, respectively. Patients occurred throughout the year, but most patients occurred between July and October. MRSA was isolated from 54 of the 60 patients regardless of the clinical types. All patients recovered without any complications. Conclusions: There was a constant occurrence of SSSS patients caused by MRSA in Changwon area during 2006 and 2015. It is needed to constantly monitor the occurrence of patients with SSSS.

목적: 경남 창원지역에서 발생한 포도알균 열상 피부 증후군의 임상 및 역학적 특징을 알아보았다. 방법: 2006년부터 2015년까지 포도알균 열상 피부 증후군으로 진단받은 69명의 환자들을 대상으로 의무기록을 검토하였다. 항생제 감수성 검사는 Clinical and Laboratory Standards Institute의 지침에 따라 한천 평판 우무 희석법을 시행하였으며, MRSA는 oxacillin 감수성검사로표현형을확인한후, mecA 유전자를 polymerase chain reaction로증폭하여최종확인하였다. 결과: 환자들의 중간연령은 2.0세이었고(범위, 0.2-6세) 임상형은 전신형이 3명(4.3%), 중간형이 53명(76.8%), 부전형이 13명(18.9%)이었다. 환자들은 연중 발생하였으나, 주로 7월부터 10월 사이에 많이 발생하였다. 배양검사를 실시한 60명의 환자 중 54명에게서 MRSA 균이 배양되었고 모든 환자들이 특별한 합병증 없이 회복되었다. 결론: 2006년부터 2015년 사이에 창원지역에서 포도알균 열상 피부 증후군 환자의 지속적인 발생이 있었다. SSSS 환자 발생에 대한 지속적인 모니터링이 필요할 것으로 생각된다.

Keywords

References

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