Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제45권2호
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  • Pages.108-115
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  • 2019
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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Risk factors of medication-related osteonecrosis of the jaw: a retrospective study in a Turkish subpopulation

  • Sahin, Onur (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University) ;
  • Odabasi, Onur (Department of Oral and Maxillofacial Surgery, Ankara Yildirim Beyazit University) ;
  • Aliyev, Toghrul (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University) ;
  • Tatar, Birkan (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Celebi University)
  • 투고 : 2018.07.02
  • 심사 : 2018.07.31
  • 발행 : 2019.04.30
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초록

Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a well-known side effect of certain drugs that are used to influence bone metabolism to treat osteometabolic disease or cancers. The purpose of our study was to investigate how high-concentration and low-concentration bisphosphonate (BP) intake affects the disease severity. Materials and Methods: Data collected from the medical records of 52 patients treated with BPs, antiresorptive, antiangiogenic drugs and diagnosed with MRONJ were included in this study. Age, sex, type of systemic disease, type of drug, duration of drug treatment, jaw area with MRONJ, drug administration protocol, and MRONJ clinical and radiological findings were obtained. Patients were divided into two groups: anti-neoplastic (Group I, n=23) and anti-osteoporotic (Group II, n=29). Statistical evaluations were performed using the IBM SPSS ver. 21.0 program. Results: In both groups, more females had MRONJ. MRONJ was found in the mandibles of 30 patients (Group I, n=14; Group II, n=16). When we classified patients according to the American Association of Oral and Maxillofacial Surgeons staging system, significant differences were seen between groups (${\chi}^2=12.23$, P<0.01). More patients with advanced stage (stage 2-3) MRONJ were found in Group I (60.9%). Conclusion: According to our results, high-concentration BP intake, age and duration of drug intake increased disease severity.

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참고문헌

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피인용 문헌

  1. Antiresorptive medication in oncology: the clinical and dental profile of patients in a reference center vol.47, pp.1, 2019, https://doi.org/10.5125/jkaoms.2021.47.1.20
  2. Conservative Management of Medication-Related Osteonecrosis of the Jaws (MRONJ): A Retrospective Cohort Study vol.10, pp.2, 2021, https://doi.org/10.3390/antibiotics10020195