Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Iron deficiency in Retired Workers exposed to Mineral dust with Chronic Obstructive Pulmonary Disease

만성폐쇄성폐질환을 동반한 광물성분진 노출 이직근로자의 철 결핍

  • Lee, Jong Seong (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Shin, Jae Hoon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Baek, Jin Ee (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Jeong, Ji Yeong (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Kim, Hyeong Geun (Incheon Hospital, Korea Workers' Compensation & Welfare Service) ;
  • Choi, Byung-Soon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service)
  • 이종성 (근로복지공단 직업환경연구원) ;
  • 신재훈 (근로복지공단 직업환경연구원) ;
  • 백진이 (근로복지공단 직업환경연구원) ;
  • 정지영 (근로복지공단 직업환경연구원) ;
  • 김형근 (근로복지공단 인천병원) ;
  • 최병순 (근로복지공단 직업환경연구원)
  • Received : 2019.02.21
  • Accepted : 2019.03.18
  • Published : 2019.03.31
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Abstract

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Iron deficiency is associated with chronic inflammation, such as COPD. The aim of this study was to evaluate the relationship among iron deficiency, iron homeostasis, and inflammation in retired miners with COPD. Methods: The serum levels of ferritin, soluble transferrin receptor(sTfR), and transferrin saturation(TSat) as biomarkers for iron deficiency and high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation and hepcidin as a biomarker for iron homeostasis were measured in 93 male subjects. Iron deficiency was defined as any one or more of (1) sTfR>28.1 nmol/L, (2) TSat<16%, and (3) ferritin< $12{\mu}g/L$. Results: Iron deficiency was found 28% of the study subjects. Median levels of serum hsCRP was significantly increased related to airflow limitation of COPD(GOLD 1, $0.09{\mu}g/dL$ vs. GOLD 2, $0.17{\mu}g/dL$ vs. GOLD $3{\leq}$, $0.30{\mu}g/dL$, p=0.010), and was positively correlated with hepcidin(p=0.009). Mean level of serum hepcidin was lower in COPD subjects with iron deficiency(p=0.004) and serum levels of hepcidin was negatively correlated with %$FEV_1$ predicted(p=0.030). Conclusions: These results suggest that high serum levels of hepcidin are related to severe airflow limitation or inflammation and can decrease iron availability, regardless of iron status.

Keywords

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Figure 1. Scatter plot showing relationship between hepcidin and %FEV1 predicted in the COPD subjects

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Figure 2. Scatter plot showing relationship between hepcidin and hsCRP in the COPD subjects

Table 1. General characteristics of study subjects(N=93)

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Table 2. Levels of hepcidin and hsCRP in serum according to general characteristics

SOOSB1_2019_v29n1_42_t0002.png 이미지

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