Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Bacillus subtilis Spore Surface Display Technology: A Review of Its Development and Applications

  • Zhang, Guoyan (School of Food and Biological Engineering, Jiangsu University) ;
  • An, Yingfeng (College of Biosciences and Biotechnology, Shenyang Agricultural University) ;
  • Zabed, Hossain M. (School of Food and Biological Engineering, Jiangsu University) ;
  • Guo, Qi (School of Food and Biological Engineering, Jiangsu University) ;
  • Yang, Miaomiao (School of Food and Biological Engineering, Jiangsu University) ;
  • Yuan, Jiao (School of Food and Biological Engineering, Jiangsu University) ;
  • Li, Wen (School of Food and Biological Engineering, Jiangsu University) ;
  • Sun, Wenjin (School of Food and Biological Engineering, Jiangsu University) ;
  • Qi, Xianghui (School of Food and Biological Engineering, Jiangsu University)
  • Received : 2018.07.13
  • Accepted : 2018.12.11
  • Published : 2019.02.28
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Abstract

Bacillus subtilis spore surface display (BSSD) technology is considered to be one of the most promising approaches for expressing heterologous proteins with high activity and stability. Currently, this technology is used for various purposes, such as the production of enzymes, oral vaccines, drugs and multimeric proteins, and the control of environmental pollution. This paper presents an overview of the latest developments in BSSD technology and its application in protein engineering. Finally, the major limitations of this technology and future directions for its research are discussed.

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