Natural Product Sciences

  • 제25권1호
  • /
  • Pages.76-80
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  • 2019
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
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Nitric Oxide Inhibitory Constituents from the Fruits of Amomum tsao-ko

  • 투고 : 2018.12.31
  • 심사 : 2019.03.06
  • 발행 : 2019.03.31
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초록

Bioactivity-guided fractionation of MeOH extract of the dried fruits of Amomum tsao-ko led to isolation of nine compounds (1 - 9). Their structures were elucidated by spectroscopic methods including extensive 1D and 2D-NMR, as alpinetin (1), naringenin-5-O-methyl ether (2), naringenin (3), hesperetin (4), 2',4',6'-trihydroxy-4-methoxy chalcone (5), tsaokoin (6), boesenbergin B (7), 4-hydroxyboesenbergin B (8), and tsaokoarylone (9). Of these, compound 8 was isolated from a natural source for the first time, which was previously reported as a synthetic product. The isolated compounds (1 - 9) were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Among them, three chalcone derivatives (compounds 5, 7, and 8) and a diarylheptanoid (compound 9) exhibited significant inhibitory activity on the NO production with $IC_{50}$ values ranging from 10.9 to $22.5{\mu}M$.

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피인용 문헌

  1. Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko vol.82, pp.7, 2019, https://doi.org/10.1021/acs.jnatprod.9b00155
  2. Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp. vol.26, pp.4, 2019, https://doi.org/10.20307/nps.2020.26.4.340
  3. 초과(草果)의 RBL-2H3 세포 항원 유도 탈과립 억제성분 vol.64, pp.1, 2021, https://doi.org/10.3839/jabc.2021.004
  4. Chemistry and bioactivity of plants from the genus Amomum vol.281, 2019, https://doi.org/10.1016/j.jep.2021.114563