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A Feasibility Study on the Improvement of Diagnostic Accuracy for Energy-selective Digital Mammography using Machine Learning

머신러닝을 이용한 에너지 선택적 유방촬영의 진단 정확도 향상에 관한 연구

  • Eom, Jisoo (Department of Medical Science, Konyang University) ;
  • Lee, Seungwan (Department of Medical Science, Konyang University) ;
  • Kim, Burnyoung (Department of Medical Science, Konyang University)
  • Received : 2018.11.26
  • Accepted : 2018.12.27
  • Published : 2019.02.28

Abstract

Although digital mammography is a representative method for breast cancer detection. It has a limitation in detecting and classifying breast tumor due to superimposed structures. Machine learning, which is a part of artificial intelligence fields, is a method for analysing a large amount of data using complex algorithms, recognizing patterns and making prediction. In this study, we proposed a technique to improve the diagnostic accuracy of energy-selective mammography by training data using the machine learning algorithm and using dual-energy measurements. A dual-energy images obtained from a photon-counting detector were used for the input data of machine learning algorithms, and we analyzed the accuracy of predicted tumor thickness for verifying the machine learning algorithms. The results showed that the classification accuracy of tumor thickness was above 95% and was improved with an increase of imput data. Therefore, we expect that the diagnostic accuracy of energy-selective mammography can be improved by using machine learning.

Keywords

References

  1. Korean Breast Cancer. Breast Cancer Facts & Figures 2018. Seoul: Korean Breast Cancer Society; 2018.
  2. Wu T, Stewart A, Stanton M, McCauley T, Phillips W, Kopans DB, et al. Tomographic Mammography using a Limited Number of Low-dose Cone-beam Projection Images. Medical Physics. 2003;30(3): 365-80. https://doi.org/10.1118/1.1543934
  3. Leschka S, Stolzmann P, Schmid FT, Scheffel H, Stinn B, Marincek B, et al. Low Kilovoltage Cardiac Dual-source CT: Attenuation, Noise, and Radiation Dose. European Radiology. 2008;18(9):1809-17. https://doi.org/10.1007/s00330-008-0966-1
  4. Lewin JM, Isaacs PK, Vance V, Larke FJ. Dual-energy Contrast-enhanced Digital Subtraction Mammography: Feasibility. Radiology. 2003;229(1): 261-8. https://doi.org/10.1148/radiol.2291021276
  5. Takahashi T, Watanabe S. Recent Progress in CdTe and CdZnTe Detectors. IEEE Transactions on Nuclear Science. 2001;48(4):950-9. https://doi.org/10.1109/23.958705
  6. Laidevant AD, Malkov S, Flowers CI, Kerlikowske, Shepherd JA. Compositional Breast Imaging using a Dual-energy Mammography Protocol. Medical Physics. 2010;37(1):164-74. https://doi.org/10.1118/1.3259715
  7. Choi Y, Cho H, Lee S, Ryu H, Lee Y. Material Decomposition in Contrast-enhanced Digital Mammography based on Photon Counting: Monte Carlo Simulation Studies. Korean Physical Society. 2011;59(1):161-8. https://doi.org/10.3938/jkps.59.161
  8. Miyajima S, Imagawa K. CdZnTe detector in Mammographic X-ray Spectroscopy, Physics in Medicine and Biology. 2002;47(22):3959. https://doi.org/10.1088/0031-9155/47/22/304
  9. Barber WC, Nygard E, Iwanczyk JS, Zhang M, Frey EC, Tsui BMW, et al. Characterization of a Novel Photon Counting Detector for Clinical CT: Count Rate, Energy Resolution. and Noise Performance. In Medical Imaging 2009: Physics of Medical Imaging. 2009;7258:725824.
  10. Geron A, Hands-on Machine Learning with Scikit-learn & Tensorflow. Korea: Hanbit Media Inc; 2016.
  11. Subasi A, Gursoy MI. EEG Signal Classification using PCA, ICA, LDA and Support Vector Machines. Expert Systems with Applications. 2010;37(12):8659-66. https://doi.org/10.1016/j.eswa.2010.06.065
  12. Zhang H, Berg AC, Marie M, Malik J. SVM-KNN: Discriminative Nearest Neighbor Classification for Visual Category Recognition. In Computer Vision and Pattern Recognition. In Computer Vision and Patten Recognition, 2006 IEEE Computer Society Conference on. 2006;2:2126-36.
  13. Jan S, Benoit D, Becheva E, Cassol F, Descourt P, Frisson T, et al. GATE V6: a Major Enhancement of the GATE Simulation Platform Enabling Modelling of CT and Radiotherapy. Physics in Medicine and Biology. 2011;56(4):881. https://doi.org/10.1088/0031-9155/56/4/001
  14. Lee C. Estimation of Computed Tomography Dose in Various Phantom Shapes and Compositions. Journal of Radiological Science and Technology. 2017;40(1):13-8. https://doi.org/10.17946/JRST.2017.40.1.03
  15. An S, Lee C, Baek C. Monte Carlo Simulation of a Varian 21EX Clinac 6 MV Photon Beam Characteristics Using GATE6. Journal of Radiological Science and Technology. 2016;39(4):571-5. https://doi.org/10.17946/JRST.2016.39.4.12
  16. Youn I, Choi S, Kook S, Choi Y. Mammographic Breast Density Evaluation in Korean Women using fully Automated Volumetric Assessment. Journal of Korean Medical Science. 2016;31(3):457-62. https://doi.org/10.3346/jkms.2016.31.3.457
  17. Castronovo A, Bellahcene A. Evidence that Breast Cancer Associated Microcalcifications are Mineralized Malignant Cell. International Journal of Oncology. 1998;12(2):305-13.
  18. Carney K. Gilmore BJ, Fogarty GWA, Desponds L. Catalogue of Diagnostic X-ray Spectra and Other Data: Report No 78. Institute of Physics and Engineering in Medicine; 1997.
  19. Desai N, Singh A, Valentino DJ. Practical Evaluation of Image Quality in Computed Radiographic (CR) Imaging Systems. In Medical Imaging 2010: Physics of Medical Imaging. International Society for Optic and Photonics. 2010;7622:76224Q.
  20. Bengio Y, Grandvalet Y. No Unbiased Estimator of the Variance of K-fold Cross Validation. Journal of Machine Learning Research. 2004:5:1089-105.
  21. Stehman SV. Selecting and Interpreting Measures of Thematic Classification Accuracy. Remote Sensing of Environment. 1997;62(1):77-89. https://doi.org/10.1016/S0034-4257(97)00083-7
  22. Buades A, Coll B, Morel JM. A Non-local Algorithm for Image Denoising, Ciboyter Vision and PAttern Recognition, 2005. CVPR 2005. IEEE Computer Society Conference on. 2005;2:60-5.
  23. Kourou K, Exarchos TP, Exarchos KP. Machine Learning Applications in Cancer Prognosis and Prediction. Computational and Structural Biotechnology Journal. 2015;13:8-17. https://doi.org/10.1016/j.csbj.2014.11.005
  24. Taguchi K, Iwanczyk JS. version 20/20: Single Photon counting X-ray Detectors in Medical Imaging. Medical Physics. 2013;40(10):100901. https://doi.org/10.1118/1.4820371