Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Terahertz (THz) imaging technology for therapeutic and diagnostic applications of cancer incorporating with radiopharmaceutical fields

  • Min, Sun-Hong (Korea Institute of Radiological & Medical Sciences) ;
  • Cho, Ilsung (Korea Institute of Radiological & Medical Sciences) ;
  • Park, Chawon (Korea Institute of Radiological & Medical Sciences) ;
  • Jung, Wongyun (Korea Institute of Radiological & Medical Sciences) ;
  • Hwang, Won Taek (Korea Institute of Radiological & Medical Sciences) ;
  • Kim, Minho (Korea Institute of Radiological & Medical Sciences) ;
  • Lee, Kyo Chul (Korea Institute of Radiological & Medical Sciences) ;
  • Lee, Yong Jin (Korea Institute of Radiological & Medical Sciences) ;
  • Lim, Sang Moo (Korea Institute of Radiological & Medical Sciences) ;
  • Hong, Bong Hwan (Korea Institute of Radiological & Medical Sciences)
  • Received : 2019.12.12
  • Accepted : 2019.12.28
  • Published : 2019.12.30
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Abstract

Radiopharmaceuticals include therapeutic radiopharmaceuticals and diagnostic radiopharmaceuticals. Therapeutic radiopharmaceuticals are administered to the body and ingested at specific organs to detect radiation emitted from the site and to construct an image to diagnose the disease. Diagnostic radiopharmaceuticals are used to treat diseases by killing cells with radiation emitted from radiopharmaceuticals, such as cancer cells, vascular endothelial cells, arthritis, and Alzheimer's disease. The application possibilities of terahertz imaging technology for the combination of radiopharmaceuticals and molecular imaging medicine are discussed and experimental methods are presented. Terahertz imaging is expected to be a powerful technique because of the effective piercing feasibility, which enables to perform safe and high resolutive imaging. To investigate the response of cell to the terahertz wave, both the pulsed and CW THz wave systems are employed. THz imaging of a rat's paraffin-embedded epithelial cell with tumor is studied in advance.

Keywords

References

  1. Wilmink GJ, Grundt JE. Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation. J Infrared Milli Terahz Waves 2011;32:1074-1122 https://doi.org/10.1007/s10762-011-9794-5
  2. Chan WL, Deibel J, Mittleman DM. Imaging with terahertz radiation. Rep. Prog. Phys. 2007;70:1325-1379 https://doi.org/10.1088/0034-4885/70/8/R02
  3. Shon CH, Chong WY, Jeon SG, Kim GJ, Kim JI, Jin YS. High Speed Terahertz Pulse Imaging in the Reflection Geometry and Image Quality Enhancement by Digital Image Processing. Int J Infrared Milli Waves 2008;29:79-88 https://doi.org/10.1007/s10762-007-9302-0
  4. Hou L, Shi. Fast broadband inexpensive weakly ionised plasma detector used in terahertz continuous-wave imaging. Electron. Lett. 2012;48:20 https://doi.org/10.1049/el.2011.2573
  5. Cheon HY, Yang HJ, Son JH. Toward Clinical Cancer Imaging Using Terahertz Spectroscopy. IEEE J. Sel. Top. Quantum Electron. 2017;23:4:8600109
  6. Park GS, Kim YH, Han HW, Han JK, Ahn JW, Son JH, Park WY, Jeong YU. Convergence of Terahertz Sciences in Biomedical Systems. Springer; 2012
  7. Pike ER, and Brown RGW. Optical Compressive Imaging. CRC Press: Taylor & Francis Group; 2017
  8. Son JH. Terahertz Biomedical Science& Technology. CRC PressTaylor & Francis Group; 2014
  9. Yin X, Brian W, Abbott D. Terahertz Imaging for Biomedical Applications. Springer: Science+Business Media, LLC; 2012
  10. Peiponen KE, Zeitler JA, and Makoto KG. Terahertz Spectroscopy and Imaging. Springer-Verlag Berlin Heidelberg; 2013
  11. Song HJ, Nagatsuma T. Handbook of Terahertz Technologies DEVICES AND APPLICATIONS. CRC Press: Taylor & Francis Group; 2015
  12. Shayne CG. Drug safety evaluation. John Wiley & Sons, Inc.; 2017
  13. Stylianou A, Talias MA. Nanotechnology-supported THz medical imaging. F1000Research 2013;2:100 https://doi.org/10.12688/f1000research.2-100.v1
  14. Sei N, Sakai T, Hayakawa K, Tanaka T, Hayakawa Y, Nakao K, Nogami K, Inagaki M. Proposal of coherent Cherenkov radiation matched to circular plane wave for intense terahertz light source. Physics Letters A 2015;379:38:2399-2404 https://doi.org/10.1016/j.physleta.2015.05.033
  15. Lee SB, Yoon GS, Lee SW, Jeong SY, Ahn BC, Lim DK, Lee JT, and Jeon YH. Combined Positron Emission Tomography and Cerenkov Luminescence Imaging of Sentinel Lymph Nodes Using PEGylated Radionuclide-Embedded Gold Nanoparticles. Small 2016;12:35:4894-4901 https://doi.org/10.1002/smll.201601721
  16. Shaffer TM, Pratt EC, Grimm J. Utilizing the power of Cerenkov light with nanotechnology. Nat. Nanotechnol. 2017;12:106-117 https://doi.org/10.1038/nnano.2016.301
  17. Vyas K. Molecular Imaging Emerges as a Cancer Surgery Tool. Photonics media 2019