Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Antidiabetic and Antioxidative Effects of Bitter Melon on Streptozotocin-induced Diabetic Rats

당뇨유발 흰쥐에 있어 여주분말의 항당뇨 및 항산화작용에 대한 연구

  • Kim, Yeon-Jeoung (Department of Food and Nutrition, Daejeon University) ;
  • Wang, Soo-Gyoung (Department of Food and Nutrition, Daejeon University) ;
  • Park, Un-Kyu (Department of Biomedical Laboratory Science, Daejeon University) ;
  • Oh, Ji-Hye (Department of Biomedical Laboratory Science, Daejeon University) ;
  • Hwang, Seock-Yeon (Department of Biomedical Laboratory Science, Daejeon University)
  • 김연정 (대전대학교 식품영양학과) ;
  • 왕수경 (대전대학교 식품영양학과) ;
  • 박운규 (대전대학교 임상병리학과) ;
  • 오지혜 (대전대학교 임상병리학과) ;
  • 황석연 (대전대학교 임상병리학과)
  • Received : 2019.09.22
  • Accepted : 2019.11.15
  • Published : 2019.12.31
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Abstract

The purpose of this study was to determine the antidiabetic and antioxidative effects of Bitter melon on streptozotocin-induced diabetic rats. The normal and the control groups were fed an AIG -93M diet, and the Bitter melon groups were fed 1%, 2% and 3% Bitter melon powder. After two weeks, the control and the experimental group were induced to a diabetic state with the administration of streptozotocin. The blood glucose control and antioxidant activity were analyzed after the animals were sacrificed. The blood glucose levels of all the Bitter melon groups were lower than those of the control group, and the 2% Bitter melon group showed significantly lower blood glucose levels than those of the control group. Serum Triglyceride and HDL-cholesterol of the 2%, and 3% Bitter melon groups were significantly lower than those of the control group. The total cholesterol levels of the bitter melon groups were significantly lower than those of the control group. The serum insulin levels of the induced groups were significantly lower than those of the normal group. The HbA1c levels of the 2% and 3% Bitter melon groups were significantly lower than those of the control group. For the level of antioxidant enzymes in the liver tissues, the 2% Bitter melon group was significantly higher than that of the control group. These results show the antidiabetic and antioxidative effects of Bitter melon for the prevention and treatment of diabetes.

본 연구의 목적은 Streptozotocin에 의한 당뇨 유발 흰쥐에 대한 여주 분말의 항당뇨병 및 항산화능 효과를 알아보기 위한 것이다. 정상 및 대조군에 AIG-93M식이를 공급하였고, 여주첨가 군에는 1%, 2%, 3%의 여주 분말을 공급하였다. 2주 후 Streptozotocin 투여로 당뇨를 유발하였다. 동물 희생 후 혈당조절과 항산화능을 분석하였다. 여주 첨가군의 혈당 수준은 모두 대조군보다 낮았으며, 2% 여주 첨가군은 대조군보다 유의하게 낮은 결과를 보였다. 2%, 3% 여주 첨가군의 혈청 트리글리세라이드와 고밀도지질단백질-콜레스테롤 수치는 대조군보다 유의하게 낮은 결과가 나왔다. 당뇨 유발 군의 혈청 인슐린은 정상군보다 유의하게 낮았다. 당화혈색소는 2% 및 3% 여주첨가 군이 대조군보다 유의하게 낮은 결과를 보였다. 간 조직에서 항산화 효소의 수치는 2% 여주첨가군이 대조군보다 유의하게 높게 나타났다. 이러한 결과는 당뇨병 예방 및 당뇨병 치료를 위한 여주 분말의 항당뇨병 및 항산화 효과를 나타내는 것으로 보여진다.

Keywords

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