DOI QR코드

DOI QR Code

A Case of Multifocal Primary Cutaneous Anaplastic Large Cell Lymphoma Managed without Surgical Treatment

외과적 치료 없이 관해된 피부 역형성 대세포 림프종 1예

  • Lim, Joonho (Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Park, Eonju (Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Eun, Seokchan (Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • 임준호 (분당서울대학교병원 성형외과) ;
  • 박언주 (분당서울대학교병원 성형외과) ;
  • 은석찬 (분당서울대학교병원 성형외과)
  • Received : 2019.10.21
  • Accepted : 2019.11.18
  • Published : 2019.11.30

Abstract

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is rare among skin malignancies. C-ALCL usually manifests as reddish or violet nodules. Surgical excision or radiation therapy is generally considered as first-line therapy, but a clinically aggressive disease may require multiagent chemotherapy. Establishing a proper diagnosis of C-ALCL is challenging but should be made to avoid inappropriate treatment and its consequences. The authors report a case of medically resolved C-ALCL in an 81-year-old man presented with well-defined nodular lesions on the forehead.

Keywords

References

  1. Sokolowska-Wojdylo M, Olek-Hrab K, Ruckemann-Dziurdzinska K. Primary cutaneous lymphomas: diagnosis and treatment. Postepy Dermatol Alergol. 2015;32:368-383.
  2. Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133:1703-1714. https://doi.org/10.1182/blood-2018-11-881268
  3. Wilson LD, Hinds GA, Yu JB. Age, race, sex, stage, and incidence of cutaneous lymphoma. Clin Lymphoma Myeloma Myeloma Leuk. 2012;12:291-296. https://doi.org/10.1016/j.clml.2012.06.010
  4. Lee HS, Suh KS, Lee DY, Cho KH, Oh SH, Kim SC, et al. Cutaneous lymphoma in Korea: A nationwide retrospective study. Acta Derm Venereol. 2016;96:535-539. https://doi.org/10.2340/00015555-2283
  5. Kempf W, Pfaltz K, Vermeer MH, Cozzio A, Ortiz-Romero PL, Bagot M, et al. EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: Lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood. 2011;118:4024-4035. https://doi.org/10.1182/blood.v118.21.4024.4024
  6. Kempf W, Sander CA. Classification of cutaneous lymphomas: An update. Histopathology. 2010;56:57-70. https://doi.org/10.1111/j.1365-2559.2009.03455.x
  7. Sidiropoulos KG, Martinez-Escala ME, Yelamos O, Guitart J, Sidiropoulos M. Primary cutaneous T-cell lymphomas: A review. J Clin Pathol. 2015;68:1003-1010. https://doi.org/10.1136/jclinpath-2015-203133
  8. Fujita H, Nagatani T, Miyazawa M, Wada H, Koiwa K, Komatsu H, et al. Primary cutaneous anaplastic large cell lymphoma successfully treated with low-dose oral methotrexate. Eur J Dermatol. 2008;18:360-361. https://doi.org/10.1684/ejd.2008.0420