Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
권호 표지
DOI QR코드

DOI QR Code

Parkinson's Disease as Risk Factor in Osteoporosis and Osteoporotic Vertebral Fracture : Prevalence Study Using National Inpatient Sample Database in Korea

  • Lee, Jin Yong (Public Health Medical Service, Boramae Medical Center, Seoul National University College of Medicine) ;
  • Lim, Nam Gu (Department of Medical Administration and Information, Daejeon Health Institute of Technology) ;
  • Chung, Chun Kee (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Lee, Jee-Young (Department of Neurology, Seoul National University Boramae Medical Center) ;
  • Kim, Hyun Joo (Department of Nursing Science, Shinsung University) ;
  • Park, Sung Bae (Department of Neurosurgery, Seoul National University Boramae Medical Center)
  • Received : 2018.01.19
  • Accepted : 2018.04.17
  • Published : 2019.01.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : To determine the prevalence of osteoporosis (OP) and osteoporotic vertebral fracture (OVF) in people with Parkinson's disease (PD) in Korea and its association with socioeconomic status. Methods : Using Health Insurance Review and Assessment Service-National Inpatient Sample (HIRA-NIS) data from 2009 to 2013, we estimated the annual prevalence of PD, OP, and OVF and investigated its association with socioeconomic status using data from National Health Insurance (NHI) beneficiaries and Medical Aid (MA) recipients. This study was supported by research funding from Korean Society for Bone and Mineral Research 2015. There were no study-specific biases related to conflicts of interest. Results : The number of PD patients in the HIRA-NIS increased each year from 2009 to 2013. Among patients with PD, the standardized prevalence rates of OP and OVF increased from 2009 to 2013; from 23.2 to 27.8 and from 2.8 to 4.2, respectively. Among patients with PD with OP, the prevalence of OVF were 12.2% and 15.1% in 2009 and 2013, respectively. The standardized prevalence rates of PD with OP and PD with OVF were significantly higher in MA recipients than in NHI beneficiaries. Conclusion : The prevalence of PD both with OP and with OVF increased and the prevalence was higher in MA recipients than in NHI beneficiaries. These findings may suggest that age over 65 years, female and low income may be a significant factor related to PD occurring with OP and OVF.

Keywords

References

  1. Benito-Leon J, Bermejo-Pareja F, Rodriguez J, Molina JA, Gabriel R, Morales JM, et al. : Prevalence of PD and other types of parkinsonism in three elderly populations of central Spain. Mov Disord 18 : 267-274, 2003 https://doi.org/10.1002/mds.10362
  2. Caslake R, Taylor K, Scott N, Gordon J, Harris C, Wilde K, et al. : Age-, gender-, and socioeconomic status-specific incidence of Parkinson's disease and parkinsonism in northeast Scotland: the PINE study. Parkinsonism Relat Disord 19 : 515-521, 2013 https://doi.org/10.1016/j.parkreldis.2013.01.014
  3. Claveria LE, Duarte J, Sevillano MD, Perez-Sempere A, Cabezas C, Rodriguez F, et al. : Prevalence of Parkinson's disease in Cantalejo, Spain: a door-to-door survey. Mov Disord 17 : 242-249, 2002 https://doi.org/10.1002/mds.10087
  4. Cole ZA, Dennison EM, Cooper C : Osteoporosis epidemiology update. Curr Rheumatol Rep 10 : 92-96, 2008 https://doi.org/10.1007/s11926-008-0017-6
  5. Cummings SR, Melton LJ : Epidemiology and outcomes of osteoporotic fractures. Lancet 359 : 1761-1767, 2002 https://doi.org/10.1016/S0140-6736(02)08657-9
  6. de Lau LM, Breteler MM : Epidemiology of Parkinson's disease. Lancet Neurol 6 : 525-535, 2006 https://doi.org/10.1016/S1474-4422(06)70471-9
  7. de Rijk MC, Breteler MM, Graveland GA, Ott A, Grobbee DE, van der Meche FG, et al. : Prevalence of Parkinson's disease in the elderly: the Rotterdam study. Neurology 45 : 2143-2146, 1995 https://doi.org/10.1212/WNL.45.12.2143
  8. Dowding CH, Shenton CL, Salek SS. A review of the health-related quality of life and economic impact of Parkinson's disease. Drugs Aging 23 : 693-721, 2006 https://doi.org/10.2165/00002512-200623090-00001
  9. Findley L, Aujla M, Bain PG, Baker M, Beech C, Bowman C, et al. : Direct economic impact of Parkinson's disease: a research survey in the United Kingdom. Mov Disord 18 : 1139-1145, 2003 https://doi.org/10.1002/mds.10507
  10. Guttman M, Slaughter PM, Theriault ME, DeBoer DP, Naylor CD : Parkinsonism in Ontario: physician utilization. Can J Neurol Sci 29 : 221-226, 2002 https://doi.org/10.1017/S0317167100001980
  11. Invernizzi M, Carda S, Viscontini GS, Cisari C : Osteoporosis in Parkinson's disease. Parkinsonism Relat Disord 5 : 339-346, 2009
  12. Kim J, Rhee CK, Yoo KH, Kim YS, Lee SW, Park YB, et al. : The health care burden of high grade chronic obstructive pulmonary disease in Korea: analysis of the Korean Health Insurance Review and Assessment Service data. Int J Chron Obstruct Pulmon Dis 8 : 561-568, 2013
  13. Kim KH, Lee K, Ko YJ, Kim SJ, Oh SI, Durrance DY, et al. : Prevalence, awareness, and treatment of osteoporosis among Korean women: the Fourth Korea National Health and Nutrition Examination Survey. Bone 50 : 1039-1047, 2012 https://doi.org/10.1016/j.bone.2012.02.007
  14. Kim L, Kim JA, Kim S : A guide for the utilization of Health Insurance Review and Assessment Service National Patient Samples. Epidemiol Health 30 : e2014008, 2014
  15. Kim L, Sakong J, Kim Y, Kim S, Kim S, Tchoe B, et al. : Developing the inpatient sample for the National Health Insurance claims data. Health Policy Manag 23 : 152-161, 2013 https://doi.org/10.4332/KJHPA.2013.23.2.152
  16. Kim YE, Lee WW, Yun JY, Yang HJ, Kim HJ, Jeon BS : Musculoskeletal problems in Parkinson's disease: neglected issues. Parkinsonism Relat Disord 19 : 666-669, 2013 https://doi.org/10.1016/j.parkreldis.2013.03.002
  17. Lee YK, Jang S, Jang S, Lee HJ, Park C, Ha YC, et al. : Mortality after vertebral fracture in Korea: analysis of the National Claim Registry. Osteoporos Int 23 : 1859-1865, 2012 https://doi.org/10.1007/s00198-011-1833-5
  18. Lix LM, Hobson DE, Azimaee M, Leslie WD, Burchill C, Hobson S : Socioeconomic variations in the prevalence and incidence of Parkinson's disease: a population-based analysis. J Epidemiol Community Health 64 : 335-340, 2010 https://doi.org/10.1136/jech.2008.084954
  19. Lyell V, Henderson E, Devine M, Gregson C : Assessment and management of fracture risk in patients with Parkinson's disease. Age Ageing 44 : 34-41, 2015 https://doi.org/10.1093/ageing/afu122
  20. National Health Insurance Service : Annual Report of National Health Insurance Statistics 2014. Available at : http://www.nhis.or.kr/menu/ retriveMenuSet.xx?menuId=F3321
  21. Navarro MC, Sosa M, Saavedra P, Lainez P, Marrero M, Torres M, et al. : Poverty is a risk factor for osteoporotic fractures. Osteoporos Int 20 : 393-398, 2009 https://doi.org/10.1007/s00198-008-0697-9
  22. Navarro Mdel C, Saavedra P, Jodar E, Gomez de Tejada MJ, Mirallave A, Sosa M : Osteoporosis and metabolic syndrome according to socioeconomic status, contribution of PTH, vitamin D and body weight: the Canarian Osteoporosis Poverty Study (COPS). Clin Endocrinol (Oxf) 78 : 681-686, 2013 https://doi.org/10.1111/cen.12051
  23. Nussbaum RL, Ellis CE : Alzheimer's disease and Parkinson's disease. N Engl J Med 348 : 1356-1364, 2003 https://doi.org/10.1056/NEJM2003ra020003
  24. Park SB, Kim J, Jeong JH, Lee JK, Chin DK, Chung CK, et al. : Prevalence and incidence of osteoporosis and osteoporotic vertebral fracture in Korea: nationwide epidemiological study focusing on differences in socioeconomic status. Spine (Phila Pa 1976) 41 : 328-336, 2016 https://doi.org/10.1097/BRS.0000000000001291
  25. Pressley JC, Louis ED, Tang MX, Cote L, Cohen PD, Glied S, et al. : The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism. Neurology 60 : 87-93, 2003 https://doi.org/10.1212/WNL.60.1.87
  26. Rascol O, Perez-Lloret S, Damier P, Delval A, Derkinderen P, Destee A, et al. : Falls in ambulatory non-demented patients with Parkinson's disease. J Neural Transm (Vienna) 122 : 1447-1455, 2015 https://doi.org/10.1007/s00702-015-1396-2
  27. Reginster JY, Burlet N : Osteoporosis: a still increasing prevalence. Bone 38 (2 Suppl 1) : S4-S9, 2006
  28. Salaffi F, Cimmino MA, Malavolta N, Carotti M, Di Matteo L, Scendoni P, et al. : The burden of prevalent fractures on health-related quality of life in postmenopausal women with osteoporosis: the IMOF study. J Rheumatol 34 : 1551-1560, 2007
  29. Saunders-Pullman R : Estrogens and Parkinson disease: neuroprotective, symptomatic, neither, or both? Endocrine 21 : 81-87, 2003 https://doi.org/10.1385/ENDO:21:1:81
  30. Seo WK, Koh SB, Kim BJ, Yu SW, Park MH, Park KW, et al. : Prevalence of Parkinson's disease in Korea. J Clin Neurosci 14 : 1155-1157, 2007 https://doi.org/10.1016/j.jocn.2006.09.005
  31. Tan L, Wang Y, Zhou L, Shi Y, Zhang F, Liu L, et al. : Parkinson's disease and risk of fracture: a meta-analysis of prospective cohort studies. PLoS One 9 : e94379, 2014 https://doi.org/10.1371/journal.pone.0094379
  32. Tison, F, Dartigues JF, Dubes L, Zuber M, Alperovitch A, Henry P : Prevalence of Parkinson's disease in the elderly: a population study in Gironde, France. Acta Neurol Scand 90 : 111-115, 1994 https://doi.org/10.1111/j.1600-0404.1994.tb02689.x
  33. von Campenhausen S, Bornschein B, Wick R, Botzel K, Sampaio C, Poewe W, et al. : Prevalence and incidence of Parkinson's disease in Europe. Eur Neuropsychopharmacol 15 : 473-490, 2005 https://doi.org/10.1016/j.euroneuro.2005.04.007
  34. Winter Y, Balzer-Geldsetzer M, Spottke A, Reese JP, Baum E, Klotsche J, et al. : Longitudinal study of the socioeconomic burden of Parkinson's disease in Germany. Eur J Neurol 17 : 1156-1163, 2010 https://doi.org/10.1111/j.1468-1331.2010.02984.x
  35. Woo HK, Park JH, Kang HS, Kim SY, Lee SI, Nam HH : Charlson Comorbidity Index as a predictor of long-term survival after surgery for breast cancer: a nationwide retrospective cohort study in South Korea. J Breast Cancer 13 : 409-417, 2010 https://doi.org/10.4048/jbc.2010.13.4.409

Cited by

  1. Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson's Disease vol.2020, 2019, https://doi.org/10.1155/2020/5027973
  2. Experience with ospemifene in patients with vulvar and vaginal atrophy: case studies with bone marker profiles vol.9, 2020, https://doi.org/10.7573/dic.2020-3-3
  3. Epidemiological Study of Tibial Plateau Fractures Combined with Intercondylar Eminence Fractures vol.12, pp.2, 2019, https://doi.org/10.1111/os.12658
  4. Osteoporotic vertebral fracture misdiagnosed as “normal postoperative phenomenon” in post decompression surgery: a case report vol.22, pp.1, 2019, https://doi.org/10.1186/s12891-020-03904-z