BMB Reports
- Volume 52 Issue 1
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- Pages.3-4
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- 2019
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- 1976-670X(eISSN)
DOI QR Code
Juxtacrine regulation of cellular senescence
- Narita, Masashi (Cancer Research UK Cambridge Institute, University of Cambridge)
- Received : 2018.11.04
- Published : 2019.01.31
Abstract
Cellular senescence is defined as a state of stable cell cycle exit in response to various stimuli, which include both cytotoxic stress and physiological cues. In addition to the core non-proliferative aspect, senescence is associated with diverse functionalities, which contribute to the role of senescence in a wide range of pathological and physiological processes. Such functionality is often mediated by the capability of senescent cells to communicate with their surroundings. Emerging evidence suggests that senescence is not a single entity, but a dynamic and heterogeneous collective phenotype. Understanding the diverse nature of senescence should provide insights into the complexity of tissue homeostasis and its disruption, such as in aging and tumorigenesis.