Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
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A Case of Surgical Treatment of Intractable Vocal Fold Scar Using Basic Fibroblast Growth Factor and Collagen Scaffold

기본섬유아세포 성장인자와 콜라겐 골격으로 치료한 난치성 성대 반흔 1예

  • Kang, Hyun Tag (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Hyo Jun (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Park, Ki Nam (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Lee, Seung Won (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital)
  • 강현택 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 김효준 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 박기남 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 이승원 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실)
  • Received : 2019.01.21
  • Accepted : 2019.07.09
  • Published : 2019.12.30
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Abstract

Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal microsurgery. Many methods are available to treat these, including voice therapy, stem cells, regenerative scaffolds, and growth factors. However, no standard treatment strategy has yet been established, and novel techniques are required. Basic fibroblast growth factor has been shown to be effective for the treatment of mild chronic vocal fold scarring. The combined use of basic fibroblast growth factor and regenerative scaffolds is currently under investigation. Here, we report a female patient in whom vocal fold scarring developed after two laryngeal microsurgeries. We performed laryngeal microsurgery to remove the scar tissue and used basic fibroblast growth factor and a collagen scaffold to promote healing. The patient's voice quality was greatly increased, and she was content with her voice after 2 years of follow-up. This is the first report of this methodology in Korea and is presented along with a review of the literature.

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References

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