Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
권호 표지
DOI QR코드

DOI QR Code

The Use of Salivary Gland Scintigraphy for Diagnosis of Primary Sjögren Syndrome and Thyroid Disease in Patients with Dry Mouth

  • Park, Keun Jeong (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry) ;
  • Kim, Bok Eum (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry) ;
  • Lee, Jung Eun (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry) ;
  • Park, YounJung (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry) ;
  • Kwon, Jeong-Seung (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry) ;
  • Ahn, Hyung-Joon (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry) ;
  • Choi, Jong-Hoon (Department of Orofacial Pain and Oral Medicine, Dental Hospital of Yonsei University College of Dentistry)
  • Received : 2019.11.28
  • Accepted : 2019.12.10
  • Published : 2019.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Sjögren syndrome (SS) is a chronic autoimmune disease characterized by dryness of the mouth and eyes due to lymphocytic infiltration of the exocrine glands. In American European Consensus Group (AECG) criteria, abnormal salivary gland scintigraphy (SGS) result is one of the objective signs of SS and it has been proposed as a valid and non-invasive alternative approach to functional evaluation of salivary gland, especially in the case when unstimulated whole salivary flow is more than 1.5 mL in 15 minutes or other AECG criteria is unmet. Patients with SS are more likely to have the thyroid disease (TD), but this association remains controversial. We present a case of the use of SGS for diagnosis of primary SS and TD in patients with dry mouth and burning sensation of tongue. Through this case, we suggest the usefulness of salivary scintigraphy for screening TD in addition to diagnosis of SS.

Keywords

References

  1. Dugonjic S, Stefanovic D, Ethurovic B, Spasic-Jokic V, Ajdinovic B. Evaluation of diagnostic parameters from parotid and submandibular dynamic salivary glands scintigraphy and unstimulated sialometry in Sjogren's syndrome. Hell J Nucl Med 2014;17:116-122.
  2. Aksoy T, Kiratli PO, Erbas B. Correlations between histopathologic and scintigraphic parameters of salivary glands in patients with Sjogren's syndrome. Clin Rheumatol 2012;31:1365-1370. https://doi.org/10.1007/s10067-012-2024-2
  3. Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-558. https://doi.org/10.1136/ard.61.6.554
  4. Umehara I, Yamada I, Murata Y, Takahashi Y, Okada N, Shibuya H. Quantitative evaluation of salivary gland scintigraphy in Sjorgen's syndrome. J Nucl Med 1999;40:64-69.
  5. Vinagre F, Santos MJ, Prata A, da Silva JC, Santos AI. Assessment of salivary gland function in Sjogren's syndrome: the role of salivary gland scintigraphy. Autoimmun Rev 2009;8:672-676. https://doi.org/10.1016/j.autrev.2009.02.027
  6. Jara LJ, Navarro C, Brito-Zeron Mdel P, Garcia-Carrasco M, Escarcega RO, Ramos-Casals M. Thyroid disease in Sjogren's syndrome. Clin Rheumatol 2007;26:1601-1606. https://doi.org/10.1007/s10067-007-0638-6
  7. Biro E, Szekanecz Z, Czirjak L, et al. Association of systemic and thyroid autoimmune diseases. Clin Rheumatol 2006;25:240-245. https://doi.org/10.1007/s10067-005-1165-y
  8. Sun X, Lu L, Li Y, Yang R, Shan L, Wang Y. Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis. PeerJ 2019;7:e6737. https://doi.org/10.7717/peerj.6737
  9. Mavragani CP, Fragoulis GE, Moutsopoulos HM. Endocrine alterations in primary Sjogren's syndrome: an overview. J Autoimmun 2012;39:354-358. https://doi.org/10.1016/j.jaut.2012.05.011
  10. Tektonidou MG, Anapliotou M, Vlachoyiannopoulos P, Moutsopoulos HM. Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases. Ann Rheum Dis 2004;63:1159-1161. https://doi.org/10.1136/ard.2004.022624
  11. Jung JH, Lee CH, Son SH, et al. High prevalence of thyroid disease and role of salivary gland scintigraphy in patients with xerostomia. Nucl Med Mol Imaging 2017;51:169-177. https://doi.org/10.1007/s13139-016-0455-4
  12. Talattof Z, Dabbaghmanesh MH, Parvizi Y, Esnaashari N, Azad A. The association between burning mouth syndrome and level of thyroid hormones in Hashimotos thyroiditis in public hospitals in Shiraz, 2016. J Dent (Shiraz) 2019;20:42-47.
  13. Afzelius P, Nielsen MY, Ewertsen C, Bloch KP. Imaging of the major salivary glands. Clin Physiol Funct Imaging 2016;36:1-10. https://doi.org/10.1111/cpf.12199