The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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A Review on Acne Treatment in Korean Medicine by Analyzing Case Studies with Herbal Medicine Treatment

국내 한약 치험례 분석을 통한 한의학적 여드름 치료법에 대한 고찰

  • Cho, Eun-Chai (College of Korean Medicine, Kyung Hee University) ;
  • Kim, Kyu-Seok (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
  • 조은채 (경희대학교 한의과대학) ;
  • 김규석 (경희대학교 한의과대학 안이비인후피부과)
  • Received : 2018.10.11
  • Accepted : 2018.11.08
  • Published : 2018.11.25
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Abstract

Objectives : The purpose of this study is 1) to explore the general tendency of the herbs or herbal formula for acne treatment in clinical practice 2) and to provide a basis for explaining the principles of acne treatment in Korean Medicine in order to make patients understand more easily based on pharmacological mechanism by analyzing the herbs or herbal formula using for acne treatment in clinical practice. Methods : In the domestic databases (Oriental medicine Advanced Searching Integrated System-OASIS, Korean Traditional Knowledge Portal-KTKP, National Discovery for Science Leader-NDSL, Research Information Sharing Service-RISS), we selected among the papers published using search terms related to "acne". Reports related to sasang constitutional medicine were excluded and a total of 23 papers were finally selected. Results : 29 prescriptions were retrieved from 23 papers. Chungan-tang (淸顔湯) notified formulas ranked first by Cheongsangbangpung- tang (淸上防風湯), Hwangnyeonhaedok-tang (黃連解毒湯), Dangguijakyaksan (當歸芍藥散) and Bipachungpe-eum (枇杷淸肺飮). Commonly used herbs are Forsythiae Fructus (連翹), Scutellariae Radix (黃芩), Gardeniae Fructus (梔子), Ligustici Rhizoma (川芎), and Angelicae Gigantis Radix (當歸). In most patients with inflammatory lesions or excessive flushing, exterior-releasing medicinal (解表藥) and heat-clearing medicinal (淸熱藥) were mainly prescribed for acne treatment, while in patients with acne accompanied hyperkeratinization, Excess sebum secretion, Dysmenorrhea or indigestion, qi-tonifying medicinal (補氣藥) or blood-tonifying medicinal (補血藥) were mainly used. KAGS (Korean Acne Grading System) was the most commonly used method for acne severity assessment. Conclusions : These findings suggest that the herbs or herbal formula for acne treatment in Korean Medicine is prescribed differently according to the cause and symptoms of acne in a unique way for control the whole body balance. Also, our findings could provide a basis for explaining the principles of acne treatment in Korean Medicine in order to make patients understand more easily based on pharmacological mechanism in clinical practice.

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References

  1. Lee WG, Kim BH, Jeon SW, Kim KS, Nam HJ, Kim YB. The Latest Trends of Treatment for Acne Vulgaris in PubMed. J Korean Med Ophthalmol Otolaryngol Dermatol. 2011;24(2):41-56. https://doi.org/10.6114/JKOOD.2011.24.2.041
  2. Kim WS, Cho SK, Kim MB, Park JH, Sung MK, CHO HR, et al. Effect of Chungan-tang and Acupuncture on Acne Patients. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015;28(4):122-9. https://doi.org/10.6114/jkood.2015.28.4.122
  3. Rhee SH. The clinical classification as identifiy of symptoms about 54 cases of patients with Acne. Korean J Korean Med Institute Dermatol Aesthetics. 2005;1(1);114-26.
  4. Na SK, Na ES. A Clinical report on Acne with Bad Smell Treated By Acupunture, Cupping and Herbs. J Soc Korean Med Diagnostics. 2014;17(2);169-77.
  5. Kyung Hee University Hospital at Gangdong Homepage. News&Data. Information about Health. 2018 July-Oct[cited 2018 Oct 10] Available form: URL: http://www.khnmc.or.kr/healthinfo/healthview.do?seq=176
  6. Jo HC, Oh EY, Jee SY, Seo BI. The Antimicrobial Activity of Cheongsangbangpungtang and its composition oriental medicines against Staphylococcus aureus. Koream J Herbol. 2003;18(2):37-47.
  7. Korean Med Ophthalmol Otolaryngol Dermatol textbook compilation committee. Text of Traditional Korean Dermatology & Surgery. 1st ed. Seoul.:Seounwoo. 2007:139-40.
  8. Oh CS, Kim MS, Kim I, Kim HY, Park SI, Choi SI, et al. Acne Treatment Cases with Hwangryeonhaedok-tang. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015;28(3):114-25. https://doi.org/10.6114/jkood.2015.28.3.114
  9. Lim JH, Oh EY, Jee SY. A Clinical Report about the Effect of Chungsangbangpungtang on Acne. J Korean Med Ophthalmol Otolaryngol Dermatol. 2003;16(2):177-88.
  10. Choi SY, Hwang DS, Lee JM, Jang JB, Lee KS, Lee CH. Acne Vulgaris Improbed in Female Patients Diagnosed as 'Stagnation Pattern' Treated with Yukul-tang Gamibang and External Treatments: 2-Case Report. J Korean Obstet Gynecol. 2015;28(2):133-42. https://doi.org/10.15204/jkobgy.2015.28.2.133
  11. Choi IH. A Clinical study of Recurrent Acne in the Oriental Medicine. J Korean Med Ophthalmol Otolaryngol Dermatol. 2000;13(2):140-51.
  12. Kim IS, Oh HS, Shin MK, Lee YS. Antimicrobial Activity of Hwangryunheadoktang, and Scutellariae Radix Extract, Phellodendri Cortex Extract, Coptis Rhizoma Extract, Gardenia Jasminoides Extract against Staphylococcus aureus. J Korean Oriental Internal Med. 2014;35(4):455-71.
  13. Yang HJ, Joo HA, Baek SC, Park JS, Hong SH. Anti-inflammatory effects of Hwangnyeonhaedok-tang and Fermented Hwangnyeonhaedok-tang. J Korean Med Ophthalmol Otolaryngol Dermatol. 2011;24(2):1-15. https://doi.org/10.6114/JKOOD.2011.24.2.001
  14. Seo ES, Hwang CY, KIm NK. Experimental study of Gagam-Cheongsan BangPungTang on the anti-inflammatory effects. J Korean Med Ophthalmol Otolaryngol Dermatol. 2008;21(2):54-70.
  15. Kim SY. Cheongsangbangpung-tang ameliorates acute inflammatory response via the inhibition of NF-kB activation and MAPK phosphorylation. Ph. D. Thesis. Daegu Haany University. Daegu, Republic of Korea. 2016. 83p.
  16. Lee ES, Seo BI. The Antimicrobial Activity of Cheongsangbangpungtang on Proteus sp. Korean J Herbol. 2004;19(2):101-8.
  17. Jo HC, Oh EY, Jee SY, Seo BI. The Antimicrobial Activity of Cheongsangbangpungtang and its composition oriental medicines against Staphylococcus aureus. Korean J Herbol. 2003;18(2):37-47.
  18. Chu CK, Jung SK, Jung HJ, Kim JJ. Research on Anti-inflammatory Effects of Forsythiae Frctus. J Korean Oriental Internal Med. 2010;31(2):242-53.
  19. Lee YS, Jung M, Lim KS, Yun YG. Study on the Anti-inflammatory Effects of the Remedy Prescripted with Lonicera japonica and Scutellaria baicalensis Radix in U937 cells. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015;28(3):1-13. https://doi.org/10.6114/jkood.2015.28.3.001
  20. Shon DH, Choi DW, Kim MH. Improvement of Anti-inflammatory Activity of Gardeniae fructus Extract by the Treatment of $\beta$-Glucosidase. Korean J food science technol. 2012;44(3):331-6. https://doi.org/10.9721/KJFST.2012.44.3.331
  21. Korean Pharmacology textbook compilation committee. Text of Koreatn Pharmacology. 4th ed. Seoul:ShinilBooks. 2015.
  22. Yoon HJ, Park YS. Effects of Scutellaria baicalensis Water Extract on Lipid Metabolism and Antioxidant Defense System in Rats Fed High Diet. J Korean Society Food Science Nutrition. 2010;39(2):219-26. https://doi.org/10.3746/jkfn.2010.39.2.219
  23. Yoon DR, Hong SI, Noh HI, Yi SR, Lee IH, Lew JH. Observation of Inflammatory Marker Levels in Sprague-Dawley Rats with Youngyopaedoc-san-related Antiatherogenic Effect. J Korean Med. 2013;34(3):86-95. https://doi.org/10.13048/jkm.13014
  24. Yu M. Review of the Kind, Pathogenesis, Treatment and Management of Acne. Master's Thesis. Konkuk University. Seoul, Republic of Korea. 2003. 85p.
  25. Kim ND. The Effects of Ginsenosides on the Blood Vessel. Latest Korean Ginseng Research. 2007:135-47.
  26. Sa EH. Antiplatelet and Antihemolysis Activity of Danggi-Jakyak-San in Human blood. Ph. D. Thesis. Dongguk University. Seoul, Republic of Korea. 2002. 28p.
  27. Saelee C. Effects of Thai medicinal herb extracts with anti-psoriatic activity on the expression on NF-kB signaling biomarkers in HaCaT keratinocytes. Mulecules. 2011; 16(5):3908-32. https://doi.org/10.3390/molecules16053908
  28. Shahnaz Begum. Comparative Hair Restorer Efficacy of Medicinal Herb on Nude(Foxn1) Mice. Biomed Res Int. 2014:319795.
  29. Kim HY. Actions of Korean Ginseng and Benzoyl Peroxide on Inflammation Relevant to Acne. J Ginseng Research. 2007;14(3):391-8.
  30. Koo EJ, Han JK, Kim YH. The Effects on Anti-inflammatory Action in HaCaT Cells and Inhibiting Sebum Secretion in SEB-1 Cells by Gleditsiae Fructus Extract. J Pediatr Korean Med. 2016;30(2):96-106. https://doi.org/10.7778/jpkm.2016.30.2.096
  31. Park JW,. Hur EJ, Lee WK. Effects of an Extract from Cimicifug a racemosa in Menopausal Women. Obstet Gynecol Science. 2002.45(1):117-21.
  32. Kim JS, Kim GY. The Clinical Observation of 8 Cases of Acnes Disease. The J Korean Med Ophthalmol Otolaryngol Dermatol. 2011;14(1):66-75.
  33. Bum HB. A Study on Acne Treatment. J Korean Med Ophthalmol Otolaryngol Dermatol.1989;2(1):73-5.
  34. Lee JA, Hong SU. A Clinical Study about the effect of Bojoongikki-tang on Acne. J Korean Med Ophthalmol Otolaryngol Dermatol. 2008:21(2);191-7.
  35. Kim DH, Kang SW, Kim BJ. Treatment for Two Cases of Acne Vulgaris with Rubus coreanus Miquel Extract. Korean J Med Mycol. 2010:15(3);140-5.
  36. Kim HS. A Case Report for Adult Acne treated by Daesiho-tang based on Shanghanlun provisions with Extrusion therapy. J Korean Med Assoc Clin Sanghan-Geumgwe. 2017;9(1):59-73.
  37. Oh HY. Development of Natural Cosmetic for Acne and Clinical Application. Ph. D. Thesis. Wonkwang University. Iksan, Republic of Korea. 2009.
  38. Kim KJ, Kim KJ. A Case about the Effect of Onkyung-tang on Acne. Kyungwon University Korea Medical Research Institute, Essay Collection. 2010;12.
  39. Lee YS, Yoon JY, Han JK, Kim YH. A Case Study about the effect of Yukmijihwangtang Gamibang and comedon extraction on Male Acne. Deajeon University Korea Medical Research Institute.2011;20(1):119-25.
  40. Hong SH. The Clincal Study on the Effect of Jeondo-san(Diandao-san) on Acnes. J. Korean Oriental Med. 2005;16(3);74-9.
  41. Kim JH, Yoo DY. A Case Report of Acne Vulgaris Patient Treated with Cheongsangbangpung-tang. Deajeon University Korea Medical Research Institute. 2013;22(1):185-91.
  42. Lee KD. Case series of skin disease. (Acne & Eczema). 1999.
  43. Jin SS, Song YK, Lim HH. Rhee SH. Acne Improved by Oriental Medical Weight Management: 2-Case Report. J Soci Korean Med Obesity Res. 2007;7(2):95-103.
  44. An JH, Kim KJ. Three Cases of Acne Vulgaris. Kyungwon University Korea Medical Research Institute, Essay Collection.2008.12.
  45. Yoon JH. A Clinical Report on 25 Years-old Female Patient With Acne In U.S.A Through Chung-we Mix Extract Powder, Houttuyniae Herba Extract and Comedone Extractor. J Soc Korean Med Diagn. 2013;17(3):287-95.
  46. Kim HY, Sung EJ, Yun CS, Yun C, An MS, Kim HY, et al. One Case Report of Inflammatory Acne Treated With the Ko-Bang(古方) and the Sa-Am acupuncture. J Korean Med Ophthalmol Otolaryngol Dermatol. 2008;21(3);226-34.
  47. National Korean Medical University Joint Coffin Compilation Committee. Text of Herbology. 3nd rev. ed. Korea:Yunglimsa, 2004.