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장애 환자의 전신 마취를 위한 세보플루란 흡입 유도 시 발생한 호흡 저하의 혈액 가스 분석

Blood Gas Analysis of Respiratory Depression during Sevoflurane Inhalation Induction for General Anesthesia in the Disabled Patients

  • 윤태완 (단국대학교 치과대학 소아치과학교실) ;
  • 김승오 (단국대학교 치과대학 치과마취학교실)
  • Yoon, Taewan (Department of Pediatric Dentistry, School of Dentistry, Dankook University) ;
  • Kim, Seungoh (Department of Anesthesiology, School of Dentistry, Dankook University)
  • 투고 : 2018.09.18
  • 심사 : 2018.10.12
  • 발행 : 2018.11.30

초록

세보플루란에 의한 일회 환기량은 낮은 용량에서는 호흡수의 증가로 안정적이다. 그러나 진정 깊이가 증가하면 폐포 환기는 세보플루란에 의해 감소되어 결과적으로는 $PaCO_2$가 증가한다. 호흡 억제의 발생은 깊이 진정된 장애 환자에서 심한 저산소증과 고탄산혈증의 위험을 증가시킨다. 세보플루란 흡입 마취는 여러 위험성이 내제되어 있으며 체내 산 염기 상태에 따라 혈역학적 변화가 발생하기에 예기치 못한 문제 상황이 발생할 수 있다. 세보플루란으로 장애인의 마취 유도 시 발생하는 호흡 억제로 인한 체내 산 염기 상태가 안정한지 알아보고자 이 연구를 진행하였다. 마취 유도는 4 vol% 세보플루란, 4 L/min 아산화질소, 4 L/min 산소를 자발 호흡 하에서 환자 안면부에 마스크를 거치하여 유도하였다. 그 뒤 환자의 의식소실 및 근육 긴장 완화 후 즉시 전문가에 의해 IV line을 거치한 뒤 정맥 채혈을 하여 정맥 내 혈액가스 분석을 하였다. 깊은 진정 상태에서 전체 환자의 평균 pH는 $7.36{\pm}0.06$으로 측정되었다. $PvCO_2$는 전체 환자에서는 평균 $48.8{\pm}8.50mmHg$로 측정되었다. $HCO_3{^-}$는 전체 환자에서 평균 $27.2{\pm}3.0mmol/L$로 측정되었다. 결론적으로 장애인을 대상으로 한 치과 진료시 세보플루란을 이용한 흡입 진정에 대한 체내 산 염기 반응은 비교적 안정적이었다.

Tidal volume by sevoflurane in small amounts is stable due to the increase in the breathing rate. But alveolus ventilation decreases due to sevoflurane as the degree of sedation increases; this ultimately causes $PaCO_2$ to rise. The occurrence of suppression of breath increases the risk of severe hypoxia and hypercapnia in deeply sedated patients with disabilities. Sevoflurane inhalation anesthesia has a number of risks and may have unexpected problems with hemodynamic changes depending on the underlying state of the body. This study was conducted to examine the stability of internal acid-base system caused by respiratory depression occurring when patients with disabilities are induced by sevoflurane. Anesthetic induction was carried out by placing a mask on top of the patient's face and through voluntary breathing with 4 vol% of sevoflurane, 4 L/min of nitrous oxide, and 4 L/min of oxygen. After the patient's loss of consciousness and muscle relaxation, IV line was inserted by an expert and intravenous blood gas was analyzed by extracting blood from vein. In a deeply sedated state, the average amount of pH of the entire patients was measured as $7.36{\pm}0.06$. The average amount of $PvCO_2$ of the entire patients was measured as $48.8{\pm}8.50mmHg$. The average amount of $HCO_3{^-}$ of the entire patients was measured as $27.2{\pm}3.0mmol/L$. In conclusion, in dental treatment of patients with disabilities, the internal acid base response to inhalation sedation using sevoflurane is relatively stable.

키워드

참고문헌

  1. Kim SO : A survey of general anesthesia, sevoflurane sedation and intravenous sedation in chungnam dental clinic for the disabled. J Korean Acad Pediatr Dent, 40:28-39, 2013.
  2. Seo KS, Shin TJ, Chang J, et al. : Clinico-statistical Analysis of Cooperation and Anesthetic Induction Method of Dental Patients with Special Needs. J Korean Dent Soc Anesthesiol, 9:9-16, 2009. https://doi.org/10.17245/jkdsa.2009.9.1.9
  3. Shin B, Yoo S, Kim J, et al. : A survey of dental treatment under general anesthesia in a Korean university hospital pediatric dental clinic. J Dent Anesth Pain Med, 16:203-208, 2016. https://doi.org/10.17245/jdapm.2016.16.3.203
  4. Saraswat V : Effects of anaesthesia techniques and drugs on pulmonary function. Indian J Anaesth, 59:557-564, 2015. https://doi.org/10.4103/0019-5049.165850
  5. The Korean Dental Society of Anesthesology : Dental Anesthesiology, 3rd ed. Koonja, Seoul, 431-433, 2015.
  6. Strum DP, Eger EI 2nd : Partition coefficients for sevoflurane in human blood, saline, and olive oil. Anesth Analg, 66:654-656, 1987.
  7. Smith I, Nathanson M, White PF : Sevoflurane-a long awaited volatile anaesthetic. Br J Anaesth, 76:435-445, 1996. https://doi.org/10.1093/bja/76.3.435
  8. Larson CP Jr, Eger EI 2nd, Eisele JH, et al. : The effects of diethyl ether and methoxyflurane on ventilation: II. A comparative study in man. Anesthesiology, 30:174-184, 1969. https://doi.org/10.1097/00000542-196902000-00014
  9. Hickey RF, Severinghaus JW : Regulation of breathing: Drug effects. In: Hornbein TF ed. Marcel Dekker, 1251, 1981.
  10. Fourcade HE, Stevens WC, Eger EI 2nd, et al. : The ventilatory effects of Forane, a new inhaled anesthetic. Anesthesiology, 35:26-31, 1971. https://doi.org/10.1097/00000542-197107000-00008
  11. Eger EI 2nd : Isoflurane: a review. Anesthesiology, 55:559-576, 1981. https://doi.org/10.1097/00000542-198111000-00014
  12. Schwieger I, Gamulin Z, Suter PM : Lung function during anesthesia and respiratory insufficiency in the postoperative period: physiological and clinical implications. Acta Anaesthesiol Scand, 33:527-534, 1989. https://doi.org/10.1111/j.1399-6576.1989.tb02960.x
  13. Ward DS, Temp JA : Neuropharmacology of the control of ventilation. Lippincott-Raven, Philadelphia, 1367-1394, 1997.
  14. Levesque PR : Acid-base disorders: application of total body carbon dioxide titration in anesthesia. Anesth Analg, 54:299-307, 1975.
  15. Berger AJ, Mitchell RA, Severinghaus JW : Regulation of respiration. N Engl J Med, 297:194-201, 1977. https://doi.org/10.1056/NEJM197707282970406
  16. Becker DE, Rosenberg M : Nitrous oxide and the inhalation anesthetics. Anesth Prog, 55:124-130, 2008. https://doi.org/10.2344/0003-3006-55.4.124
  17. Eilers H : Basics of Anesthesia, 4th ed. Churcill Livingstone Elsevier, 97-111, 2007.
  18. Williams AJ : ABC of oxygen: assessing and interpreting arterial blood gases and acid-base balance. BMJ, 317:1213-1216, 1998. https://doi.org/10.1136/bmj.317.7167.1213
  19. Rao SM, Nagendranath V. Arterial blood gas monitoring. Indian J Anaesth, 46:289-297, 2002.
  20. Holaday DA, Smith FR : Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers. Anesthesiology, 54:100-106, 1981. https://doi.org/10.1097/00000542-198102000-00002
  21. The Korean Dental Society of Anesthesology : Dental Anesthesiology, 3rd ed. Koonja, Seoul, 512, 2015.
  22. Lee WH, Park CJ, Yum KW, et al. : Inhalational deep sedation using sevoflurane in Pediatric Dental Patients. J Korean Dent Soc Anesthesiol, 4:90-95, 2004. https://doi.org/10.17245/jkdsa.2004.4.2.90