DOI QR코드

DOI QR Code

바이오 이미징을 위한 업컨버전 나노입자(upconversion nanoparticles)의 합성 및 특성화

Synthesis and Functionalization of Upconversion Nanoparticles for Bioimaging

  • 조혜인 (고려대학교 신소재공학부) ;
  • 이재승 (고려대학교 신소재공학부)
  • Cho, Hye In (Department of Materials Science and Engineering, Korea University) ;
  • Lee, Jae-Seung (Department of Materials Science and Engineering, Korea University)
  • 투고 : 2018.08.08
  • 심사 : 2018.08.23
  • 발행 : 2018.09.30

초록

The increasing importance of biomedical imaging technology has led to the development of a variety of luminescent materials, including molecular fluorophores, fluorescent proteins, and quantum dots. Owing to their inherent disadvantages, such as insufficient chemical stability and limited biocompatability, their utilization has been limited with imaging only under highly optimized and controlled conditions. Recently, a new class of luminescent nanoparticles, upconversion nanoparticles (UCNPs), have been emerging as a practically useful nanoprobe for various bioimaging applications. The detailed synthesis, functionalization, properties and in-vitro / in-vivo applications of the UCNPs are introduced and discussed in this Review.

키워드

참고문헌

  1. 송요한, 이강택, "업컨버팅 나노입자(upconverting nanoparticle, UCNP)를 이용한 바이오 이미징(in Korean)," 화학세계, 56 [2] 20-25 (2016).
  2. 조은정, 김민곤, "업컨버팅 나노입자(upconverting nanoparticle, UCNP)의 합성 및 바이오센싱 응용(in Korean)," 화학세계, 56 [2] 13-19 (2016).
  3. Y. M. Yang, "Upconversion nanophosphors for use in bioimaging, therapy, drug delivery and bioassays," Microchimica Acta, 181 [3-4] 263-94 (2014). https://doi.org/10.1007/s00604-013-1139-8
  4. O. S. Wolfbeis, "An overview of nanoparticles commonly used in fluorescent bioimaging," Chemical Society Reviews, 44 [14] 4743-68 (2015). https://doi.org/10.1039/C4CS00392F
  5. B. Zhou, B. Y. Shi, D. Y. Jin, and X. G. Liu, "Controlling upconversion nanocrystals for emerging applications," Nat Nanotechnol, 10 [11] 924-36 (2015). https://doi.org/10.1038/nnano.2015.251
  6. D. G. Yin, C. C. Wang, J. Ouyang, X. Y. Zhang, Z. Jiao, Y. Feng, K. L. Song, B. Liu, X. Z. Cao, L. Zhang, Y. L. Han, and M. H. Wu, "Synthesis of a Novel Core-Shell Nanocomposite $Ag@SiO_2@\;Lu_2O_3$:Gd/Yb/Er for Large Enhancing Upconversion Luminescence and Bioimaging," Acs Appl Mater Inter, 6 [21] 18480-88 (2014). https://doi.org/10.1021/am505633g
  7. D. W. Lu, S. K. Cho, S. Ahn, L. Brun, C. J. Summers, and W. Park, "Plasmon Enhancement Mechanism for the Upconversion Processes in NaYF4: $Yb^{3+},Er^{3+}$ Nanoparticles: Maxwell versus Forster," Acs Nano, 8 [8] 7780-92 (2014). https://doi.org/10.1021/nn5011254
  8. F. Wang and X. G. Liu, "Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals," Chemical Society Reviews, 38 [4] 976-89 (2009). https://doi.org/10.1039/b809132n
  9. F. Wang, D. Banerjee, Y. S. Liu, X. Y. Chen, and X. G. Liu, "Upconversion nanoparticles in biological labeling, imaging, and therapy," Analyst, 135 [8] 1839-54 (2010). https://doi.org/10.1039/c0an00144a
  10. H. J. M. A. A. Zijlmans, J. Bonnet, J. Burton, K. Kardos, T. Vail, R. S. Niedbala, and H. J. Tanke, "Detection of cell and tissue surface antigens using up-converting phosphors: A new reporter technology," Anal Biochem, 267 [1] 30-36 (1999). https://doi.org/10.1006/abio.1998.2965
  11. M. X. Yu, F. Y. Li, Z. G. Chen, H. Hu, C. Zhan, H. Yang, and C. H. Huang, "Laser Scanning Up-Conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-Earth Nanophosphors," Anal Chem, 81 [3] 930-35 (2009). https://doi.org/10.1021/ac802072d
  12. S. Jiang, Y. Zhang, K. M. Lim, E. K. W. Sim, and L. Ye, "NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA," Nanotechnology, 20 [15] (2009).
  13. S. Jiang and Y. Zhang, "Upconversion Nanoparticle-Based FRET System for Study of siRNA in Live Cells," Langmuir, 26 [9] 6689-94 (2010). https://doi.org/10.1021/la904011q
  14. S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C. K. Tung, D. Tank, and R. H. Austin, "In vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans," Nano Lett, 6 [2] 169-74 (2006). https://doi.org/10.1021/nl0519175
  15. G. Y. Chen, H. L. Qju, P. N. Prasad, and X. Y. Chen, "Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics," Chem Rev, 114 [10] 5161-214 (2014). https://doi.org/10.1021/cr400425h
  16. C. T. Xu, J. Axelsson, and S. Andersson-Engels, "Fluorescence diffuse optical tomography using upconverting nanoparticles (vol 94, 251107, 2009)," Appl Phys Lett, 95 [3] (2009).
  17. S. L. Gai, C. X. Li, P. P. Yang, and J. Lin, "Recent Progress in Rare Earth Micro/Nanocrystals: Soft Chemical Synthesis, Luminescent Properties, and Biomedical Applications," Chem Rev, 114 [4] 2343-89 (2014). https://doi.org/10.1021/cr4001594
  18. J. Zhou, Y. Sun, X. X. Du, L. Q. Xiong, H. Hu, and F. Y. Li, "Dual-modality in vivo imaging using rareearth nanocrystals with near-infrared to nearinfrared (NIR-to-NIR) upconversion luminescence and magnetic resonance properties," Biomaterials, 31 [12] 3287-95 (2010). https://doi.org/10.1016/j.biomaterials.2010.01.040