The Journal of Korean Academy of Prosthodontics (대한치과보철학회지)

The Korean Academy of Prosthodonitics (대한치과보철학회)
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A review of biocompatibility of zirconia: In vitro experiment

지르코니아의 생체적합성에 대한 연구: In vitro 실험 문헌 고찰

  • Suh, Da-Won (School of Dentistry, Seoul National University) ;
  • Kim, Young-Kyun (Department of Oral & Maxillofacial Surgery, Seoul National University Bundang Hospital, Seongnam, School of Dentistry, Seoul National University) ;
  • Yi, Yang-Jin (Department of Prosthodontics, Seoul National University Bundang Hospital, Seongnam, School of Dentistry, Seoul National University)
  • 서다원 (서울대학교 치의학대학원) ;
  • 김영균 (분당서울대병원 구강악안면외과) ;
  • 이양진 (분당서울대병원 치과보철과)
  • Received : 2018.09.19
  • Accepted : 2018.10.19
  • Published : 2018.10.31
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Abstract

Increasing demands for zirconia material in clinics, assessment of biocompatibility of zirconia is essential. In this article, a review of in vitro studies of zirconia compatibility was performed. Zirconia showed great biocompatibility at in vitro studies with various cell lines such as fibroblasts, osteoblasts, and lymphocytes. Many studies reported that zirconia caused no cytotoxicity or mutation. Zirconia also showed less bacterial adhesion. There were no adverse effects except for small reduced strength with in vitro study mimicking long-term exposure of body fluid. According to the study with ostoblast-like cells, zirconia could regulate genes of immunity, molecular transport, and cell cycle. Such gene regulating was considered as one of the reasons of zirconia biocompatibility. With biocompatibility of zirconia powders, in vitro studies had controversial conclusions. It seems that zirconia powders might have cytotoxicity.

진료실에서 지르코니아의 수요가 증가하고 있음에 따라 지르코니아의 생체적합성에 대한 평가가 필수적이다. 이번 논문에서는 지르코니아의 생체적 합성에 대한 문헌 중 in vitro 실험에서의 결과를 고찰하였다. Fibroblast, osteoblast, lymphocyte 등 다양한 세포를 이용한 in vitro 실험에서 지르코니아 블록은 뛰어난 생체적합성을 보였다. 여러 연구에서 지르코니아에 대한 세포독성 및 돌연변이 유발이 관찰되지 않았으며, 세균부착도 적은 것으로 나타났다. 장기간 체액노출조건을 모방한 in vitro 실험에서는 약간의 기계적 강도의 감소 외에는 악영향이 관찰되지 않았다. Osteoblast-like cell을 이용한 연구에서, 지르코니아 블록이 면역반응, 물질이동, 세포주기조절에 관여하는 유전자를 조절하여 생체적합을 높이는 것으로 관찰되었다. 여러 in vitro 연구에서 지르코니아 분말의 생체적합성에 대해서는 상이한 보고가 나타나고 있다. 종합적으로 지르코니아 분말은 어느 정도 세포독성을 가지고 있는 것으로 생각된다.

Keywords

References

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