Korean Journal of Anesthesiology

  • 제71권6호
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  • Pages.440-446
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  • 2018
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  • 2005-6419(pISSN)
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  • 2005-7563(eISSN)
대한마취통증의학회 (The Korean Society of Anesthesiologists)
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Aprepitant in combination with palonosetron for the prevention of postoperative nausea and vomiting in female patients using intravenous patient-controlled analgesia

  • Yoo, Jae Hwa (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital) ;
  • Kim, Soon Im (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital) ;
  • Chung, Ji Won (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital) ;
  • Jun, Mi Roung (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital) ;
  • Han, Yoo Mi (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital) ;
  • Kim, Yong Jik (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital)
  • 투고 : 2018.01.12
  • 심사 : 2018.04.28
  • 발행 : 2018.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background: The aim of this study was to evaluate aprepitant in combination with palonosetron as compared to palonosetron alone for the prevention of postoperative nausea and vomiting (PONV) in female patients receiving fentanyl-based intravenous patient-controlled analgesia (IV-PCA). Methods: In this randomized single-blinded study, 100 female patients scheduled for elective surgery under general anesthesia were randomized to two groups: Group AP (80 mg aprepitant plus 0.075 mg palonosetron, n = 50) and Group P (0.075 mg palonosetron, n = 50). The patients in group AP received 80 mg aprepitant per oral 1-3 h before surgery, while all patients received 0.075 mg palonosetron after induction of standardized anesthesia. All patients had postoperative access to fentanyl-based IV-PCA. The incidence of nausea and vomiting, use of rescue medication, and severity of nausea were evaluated at 6 and 24 h after surgery. Results: The incidence of nausea (54%) and vomiting (2%) in group AP did not differ significantly from that in group P (48% and 14%, respectively) during the first 24 h after surgery (P > 0.05). Patient requirements for rescue medication in group AP (29%) were similar to those in group P (32%) at 24 h after surgery (P > 0.05). There was no difference between the groups in severity of nausea during the first 24 h after surgery (P > 0.05). Conclusions: Aprepitant combined with palonosetron did not reduce the incidence of PONV as compared to palonosetron alone within 24 h of surgery in women receiving fentanyl-based IV-PCA.

키워드

과제정보

연구 과제 주관 기관 : Soonchunhyang University

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피인용 문헌

  1. Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting vol.131, pp.2, 2018, https://doi.org/10.1213/ane.0000000000004833
  2. Prevention and Treatment of Postoperative Nausea and Vomiting (PONV): A Review of Current Recommendations and Emerging Therapies vol.16, pp.None, 2018, https://doi.org/10.2147/tcrm.s256234
  3. Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review vol.9, pp.None, 2018, https://doi.org/10.12688/f1000research.21832.1
  4. Neurokinin-1 Antagonists for Postoperative Nausea and Vomiting vol.81, pp.10, 2021, https://doi.org/10.1007/s40265-021-01532-y