Journal of the Korean neurological association (대한신경과학회지)

Korean Neurological Association (대한신경과학회)
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Bilateral Lesions in the Posterior Limb of Internal Capsule Attributed to Combination Therapy of Isoniazid and Rifampin

이소니아지드와 리팜핀 복합 치료에 의하여 발생한 속섬유막뒤다리의 양측성 병변

  • Park, Min Won (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Roh, Jinhong (Department of Neurology, Saetongyoung Hospital) ;
  • Im, Seojun (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Kim, Min Ok (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Kim, Young-Soo (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Kang, Jongsoo (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Kim, Do-Hyung (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Kwon, Oh-Young (Department of Neurology and Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine)
  • 박민원 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원) ;
  • 노진홍 (새통영병원 신경과) ;
  • 임서준 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원) ;
  • 김민옥 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원) ;
  • 김영수 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원) ;
  • 강종수 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원) ;
  • 김도형 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원) ;
  • 권오영 (경상대학교 의과대학 경상대학교병원 신경과 건강과학연구원)
  • Received : 2018.07.13
  • Accepted : 2018.09.03
  • Published : 2018.11.30
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Abstract

Transient isoniazid-induced brain lesions have rarely been reported. The lesions were in the dentate nucleus of cerebellum and thalamus. Meanwhile, the neurotoxicity of rifampin has not been reported evidently. We observed bilateral lesions in the internal capsule in a young woman after taking a combination of isoniazid and rifampin. She transiently suffered numbness in both hands, dysarthria, and left side motor weakness while taking the medication. Isoniazid may induce structural lesions in various brain areas including the internal capsule.

Keywords

References

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