Journal of the Korean neurological association (대한신경과학회지)

Korean Neurological Association (대한신경과학회)
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Small Fiber Neuropathy and Postural Orthostatic Tachycardia Syndrome after Human Papillomavirus Vaccination

사람유두종바이러스 백신접종 후 발생한 소섬유신경병과 기립빈맥증후군

  • Lee, Chaewon (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lim, Young-Min (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ko, Myung-A (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Hyunjin (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Kwang-Kuk (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine)
  • 이채원 (울산대학교 의과대학 서울아산병원 신경과) ;
  • 임영민 (울산대학교 의과대학 서울아산병원 신경과) ;
  • 고명아 (울산대학교 의과대학 서울아산병원 신경과) ;
  • 김현진 (울산대학교 의과대학 서울아산병원 신경과) ;
  • 김광국 (울산대학교 의과대학 서울아산병원 신경과)
  • Received : 2018.03.15
  • Accepted : 2018.06.18
  • Published : 2018.11.30
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Abstract

We describe a 44-year-old woman with paresthesia, fatigue, and palpitation, 10 days after human papillomavirus (HPV) vaccination. The quantitative sensory test showed abnormal detection threshold in her foot. Tilt test result indicated postural orthostatic tachycardia syndrome. Symptoms were improved after immunomodulating therapy, pain control drug, and oral beta blocker medication. This is first case report for small fiber neuropathy and autonomic dysfunction after HPV vaccination in Korea.

Keywords

References

  1. Garland SM, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007;356:1928-1943. https://doi.org/10.1056/NEJMoa061760
  2. Martinez-Lavin M, Martinez-Martinez LA, Reyes-Loyola P. HPV vaccination syndrome. a questionnaire-based study. Clin Rheumatol 2015;34:1981-1983. https://doi.org/10.1007/s10067-015-3070-3
  3. Brinth L, Theibel AC, Pors K, Mehlsen J. Suspected side effects to the quadrivalent human papilloma vaccine. Dan Med J 2015;62:A5064.
  4. Berger M, McCallus DE, Lin CS. Rapid and reversible responses to IVIG in autoimmune neuromuscular diseases suggest mechanisms of action involving competition with functionally important autoantibodies. J Peripher Nerv Syst 2013;18:275-296. https://doi.org/10.1111/jns5.12048
  5. Rodriguez-Galan MA, Perez-Vilar S, Diez-Domingo J, Tuells J, Gomar-Fayos J, Morales-Olivas F, et al. Adverse reactions to human papillomavirus vaccine in the Valencian community (2007-2011). An Pediatr (Barc) 2014;81:303-309. https://doi.org/10.1016/j.anpedi.2013.11.031
  6. Oaklander AL. Immunotherapy prospects for painful small-fiber sensory neuropathies and ganglionopathies. Neurotherapeutics 2016;13:108-117. https://doi.org/10.1007/s13311-015-0395-1
  7. Martinez-Lavin M. Hypothesis: human papillomavirus vaccination syndrome--small fiber neuropathy and dysautonomia could be its underlying pathogenesis. Clin Rheumatol 2015;34:1165-1169. https://doi.org/10.1007/s10067-015-2969-z
  8. Blitshteyn S. Postural tachycardia syndrome following human papillomavirus vaccination. Eur J Neurol 2014;21:135-139. https://doi.org/10.1111/ene.12272
  9. Kinoshita T, Abe RT, Hineno A, Tsunekawa K, Nakane S, Ikeda S. Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine. Intern Med 2014;53:2185-2200. https://doi.org/10.2169/internalmedicine.53.3133
  10. Poddighe D, Vadala M, Laurino C, Palmieri B. Somatoform and neurocognitive syndromes after HPV immunization are not associated to cell-mediated hypersensitivity to aluminum. Toxicol In Vitro 2017;43:58-61. https://doi.org/10.1016/j.tiv.2017.06.003