Journal of the Korean neurological association (대한신경과학회지)

Korean Neurological Association (대한신경과학회)
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Orthostatic Hypotension and Cognitive Function in Parkinson's Disease

파킨슨병에서 기립저혈압과 인지 기능의 관계

  • Kim, Sooyoung (Department of Neurology, Chungnam National University School of Medicine) ;
  • Lee, Juyoun (Department of Neurology, Chungnam National University School of Medicine) ;
  • Oh, Eungseok (Department of Neurology, Chungnam National University School of Medicine) ;
  • Sohn, Eun Hee (Department of Neurology, Chungnam National University School of Medicine) ;
  • Lee, Ae Young (Department of Neurology, Chungnam National University School of Medicine)
  • 김수영 (충남대학교 의과대학 신경과학교실) ;
  • 이주연 (충남대학교 의과대학 신경과학교실) ;
  • 오응석 (충남대학교 의과대학 신경과학교실) ;
  • 손은희 (충남대학교 의과대학 신경과학교실) ;
  • 이애영 (충남대학교 의과대학 신경과학교실)
  • Received : 2018.04.29
  • Accepted : 2018.09.03
  • Published : 2018.11.30
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Abstract

Background: Although orthostatic hypotension (OH) and cognitive impairment (CI) are common non- motor symptoms of Parkinson's disease (PD), the relationship between OH and CI remains to be clarified. This study was aimed to investigate the relationship between OH and CI in PD. Methods: We recruited 192 patients who were diagnosed as PD based on the UK Brain Bank diagnostic criteria. The Hoehn & Yahr stages were ranged I to III and patients underwent extensive clinical evaluation, including brain magnetic resonance imaging (MRI) for cerebral white matter hyperintensity (WMH), tilt table test, the Korean version of Montreal Cognitive Assessments and the Korean version of Mini-Mental Status Examination in one month from the first clinic visit. The participants were divided into two groups according to the presence of OH (OH+ vs. OH-) and cognitive function (cognitive normal, CN vs. CI), respectively. Results: Significant relationship between OH and cognitive function (p=0.04) was found in our patients. The patients with OH+ had higher risk of CI by 2.6 times than that of OH- patients. Maximum heart rate change during tilt table test was correlated with cognitive function and white matter changes, whereas blood pressure change during tilt table test showed no correlation with those parameters. Conclusions: There was significant relationship between OH and CI in PD. Therefore, PD patients with either symptom may need periodic evaluation and proper management for OH and cognitive functions.

Keywords

References

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