Infection and chemotherapy

The Korean Society of Infectious Diseases (대한감염학회)
권호 표지
DOI QR코드

DOI QR Code

Successful Treatment of Catheter Related Blood Stream Infection By Millerozyma farinosa with Micafungin: A Case Report

  • Hong, Sun In (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Suh, Young Sun (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Kim, Hyun-Ok (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine) ;
  • Bae, In-Gyu (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Shin, Jong Hee (Department of Laboratory Medicine, Chonnam National University Medical School) ;
  • Cho, Oh-Hyun (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine)
  • Received : 2017.11.12
  • Accepted : 2017.12.27
  • Published : 2018.12.31
⟨ Previous Next ⟩

Abstract

Millerozyma farinosa (formerly Pichia farinosa) is halotolerant yeast mainly found in food and ubiquitous in the environment. It was a rare yeast pathogen, but it has recently emerged as a cause of fungemia in immunocompromised patients. Optimal therapy for invasive fungal infection by this pathogen remains unclear. We report a case of catheter related blood stream infection caused by M. farinosa in a 71-year-old patient who recovered successfully after removal of the central venous catheter and treatment with micafungin.

Keywords

Acknowledgement

Supported by : Gyeongsang National University Hospital (GNUH)

References

  1. Dujon B. Yeast evolutionary genomics. Nat Rev Genet 2010;11:512-24.
  2. Lages F, Silva-Graca M, Lucas C. Active glycerol uptake is a mechanism underlying halotolerance in yeasts: a study of 42 species. Microbiology 1999;145:2577-85. https://doi.org/10.1099/00221287-145-9-2577
  3. Suzuki C, Ando Y, Machida S. Interaction of SMKT, a killer toxin produced by Pichia farinosa, with the yeast cell membranes. Yeast 2001;18:1471-8. https://doi.org/10.1002/yea.791
  4. Mallet S, Weiss S, Jacques N, Leh-Louis V, Sacerdot C, Casaregola S. Insights into the life cycle of yeasts from the CTG clade revealed by the analysis of the Millerozyma (Pichia) farinosa species complex. PLoS One 2012;7:e35842. https://doi.org/10.1371/journal.pone.0035842
  5. Anaissie E, Bodey GP, Kantarjian H, Ro J, Vartivarian SE, Hopfer R, Hoy J, Rolston K. New spectrum of fungal infections in patients with cancer. Rev Infect Dis 1989;11:369-78. https://doi.org/10.1093/clinids/11.3.369
  6. Hofmeyr A, Slavin MA. Emerging opportunistic yeast infections in haematology patients. Leuk Lymphoma 2006;47:1736-7. https://doi.org/10.1080/10428190600741161
  7. Adler A, Hidalgo-Grass C, Boekhout T, Theelen B, Sionov E, Polacheck I. Pichia farinosa bloodstream infection in a lymphoma patient. J Clin Microbiol 2007;45:3456-8. https://doi.org/10.1128/JCM.00788-07
  8. Garcia-Martos P, Mira J, Galan F, Hernandez JM. Sexual forms of yeasts in clinical samples. Mycopathologia 1996-1997;136:67-70. https://doi.org/10.1007/BF00437497
  9. Paula CR, Sampaio MC, Birman EG, Siqueira AM. Oral yeasts in patients with cancer of the mouth, before and during radiotherapy. Mycopathologia 1990;112:119-24. https://doi.org/10.1007/BF00436507
  10. Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 2016;62:e1-50. https://doi.org/10.1093/cid/ciw103
  11. Shin DH, Park JH, Shin JH, Suh SP, Ryang DW, Kim SJ. Pichia ohmeri fungemia associated with phlebitis: successful treatment with amphotericin B. J Infect Chemother 2003;9:88-9. https://doi.org/10.1007/s10156-002-0208-Z
  12. Ostronoff F, Ostronoff M, Calixto R, Domingues MC, Souto Maior AP, Sucupira A, Florencio R, Tagliari C. Pichia ohmeri fungemia in a hematologic patient: an emerging human pathogen. Leuk Lymphoma 2006;47:1949-51. https://doi.org/10.1080/10428190600679031
  13. Yang BH, Peng MY, Hou SJ, Sun JR, Lee SY, Lu JJ. Fluconazole-resistant Kodamaea ohmeri fungemia associated with cellulitis: case report and review of the literature. Int J Infect Dis 2009;13:e493-7. https://doi.org/10.1016/j.ijid.2009.02.003
  14. Shaaban H, Choo HF, Boghossian J, Perez G. Kodamaea ohmeri fungemia in an immunocompetent patient treated with micafungin: case report and review of the literature. Mycopathologia 2010;170:223-8. https://doi.org/10.1007/s11046-010-9315-4
  15. Kanno Y, Wakabayashi Y, Ikeda M, Tatsuno K, Misawa Y, Sato T, Yanagimoto S, Okugawa S, Moriya K, Yotsuyanagi H. Catheter-related bloodstream infection caused by Kodamaea ohmeri: a case report and literature review. J Infect Chemother 2017;23:410-4. https://doi.org/10.1016/j.jiac.2017.01.003
  16. Chan AW, Cartwright EJ, Reddy SC, Kraft CS, Wang YF. Pichia anomala (Candida pelliculosa) fungemia in a patient with sickle cell disease. Mycopathologia 2013;176:273-7. https://doi.org/10.1007/s11046-013-9677-5
  17. Valenza G, Valenza R, Brederlau J, Frosch M, Kurzai O. Identification of Candida fabianii as a cause of lethal septicaemia. Mycoses 2006;49:331-4. https://doi.org/10.1111/j.1439-0507.2006.01240.x
  18. Hamal P, Ostransky J, Dendis M, Horvath R, Ruzicka F, Buchta V, Vejsova M, Sauer P, Hejnar P, Raclavsky V. A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment. Med Mycol 2008;46:601-5. https://doi.org/10.1080/13693780802078180
  19. Gabriel F, Noel T, Accoceberry I. Lindnera (Pichia) fabianii blood infection after mesenteric ischemia. Med Mycol 2012;50:310-4. https://doi.org/10.3109/13693786.2011.587455
  20. Yun JW, Park KS, Ki CS, Lee NY. Catheter-related bloodstream infection by Lindnera fabianii in a neutropenic patient. J Med Microbiol 2013;62:922-5. https://doi.org/10.1099/jmm.0.048306-0