구강생물연구 (Oral Biology Research)

  • 제42권4호
  • /
  • Pages.198-207
  • /
  • 2018
  • /
  • 2508-2558(pISSN)
  • /
  • 2508-2566(eISSN)
조선대학교 치의학연구원 (The Institute of Dental Science, Chosun University)
권호 표지
DOI QR코드

DOI QR Code

A study of bone regeneration effect according to the two different graft bone materials in the cranial defects of rabbits

  • Song, Hyun-Jong (Department of Dentistry, Suncheon Hankook Hospital) ;
  • Kim, Hyun-Woo (Department of Periodontology, School of Dentistry, Chosun University) ;
  • Min, Gwi-Hyeon (Department of Periodontology, School of Dentistry, Chosun University) ;
  • Lee, Won-Pyo (Department of Periodontology, School of Dentistry, Chosun University) ;
  • Yu, Sang-Joun (Department of Periodontology, School of Dentistry, Chosun University) ;
  • Kim, Byung-Ock (Department of Periodontology, School of Dentistry, Chosun University)
  • 투고 : 2018.12.11
  • 심사 : 2018.12.13
  • 발행 : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Guided tissue regeneration (GBR) has been used to promote new bone formation in alveolar bone reconstruction at defective bone sites following tooth loss. Bone grafts used in GBR can be categorized into autogenous, xenogenous, and synthetic bones, and human allografts depending on the origin. The purpose of this study was to compare the rates of bone regeneration using two different bone grafts in the cranial defects of rabbits. Ten New Zealand rabbits were used in this study. Four defects were created in each surgical site. Each defect was filled as follows: with nothing, using a 50% xenograft and 50% human freeze-dried bone allograft (FDBA) depending on the volume rate, human FDBA alone, and xenograft alone. After 4 to 8 weeks of healing, histological and histomorphometric analyses were carried out. At 4 weeks, new bone formation occurred as follows: 18.3% in the control group, 6.5% in group I, 8.8% in group II, and 4.2% in group III. At 8 weeks, the new bone formation was 14.9% in the control group, 36.7% in group I, 39.2% in group II, and 16.8% in group III. The results of this study suggest that the higher the proportion of human FDBA in GBR, the greater was the amount of clinically useful new bone generated. The results confirm the need for adequate healing period to ensure successful GBR with bone grafting.

키워드

과제정보

연구 과제 주관 기관 : Chosun University Dental Hospital

참고문헌

  1. Bartee BK. Extraction site reconstruction for alveolar ridge preservation. Part 1: rationale and materials selection. J Oral Implantol 2001;27:187-193. doi: 10.1563/1548-1336(2001)027<0187:ESRFAR>2.3.CO;2.
  2. Sclar AG. Strategies for management of single-tooth extraction sites in aesthetic implant therapy. J Oral Maxillofac Surg 2004;62(9 Suppl 2):90-105. doi: 10.1016/j.joms.2004.06.041.
  3. Jambhekar S, Kernen F, Bidra AS. Clinical and histologic outcomes of socket grafting after flapless tooth extraction: a systematic review of randomized controlled clinical trials. J Prosthet Dent 2015;113:371-382. doi: 10.1016/j.prosdent.2014.12.009.
  4. Trombelli L, Farina R, Marzola A, Bozzi L, Liljenberg B, Lindhe J. Modeling and remodeling of human extraction sockets. J Clin Periodontol 2008;35:630-639. doi: 10.1111/j.1600-051X.2008.01246.x.
  5. Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res 2012;23 Suppl 5:1-21. doi: 10.1111/j.1600-0501.2011.02375.x.
  6. Van der Weijden F, Dell'Acqua F, Slot DE. Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review. J Clin Periodontol 2009;36:1048-1058. doi: 10.1111/j.1600-051X.2009.01482.x.
  7. Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol 2005;32:212-218. doi: 10.1111/j.1600-051X.2005.00642.x.
  8. Araujo MG, Sukekava F, Wennstrom JL, Lindhe J. Ridge alterations following implant placement in fresh extraction sockets: an experimental study in the dog. J Clin Periodontol 2005;32:645-652. doi: 10.1111/j.1600-051X.2005.00726.x.
  9. Araujo M, Linder E, Wennström J, Lindhe J. The influence of Bio-Oss Collagen on healing of an extraction socket: an experimental study in the dog. Int J Periodontics Restorative Dent 2008;28:123-135. doi: 10.11607/prd.00.0789.
  10. Araujo MG, Lindhe J. Ridge alterations following tooth extraction with and without flap elevation: an experimental study in the dog. Clin Oral Implants Res 2009;20:545-549. doi: 10.1111/j.1600-0501.2008.01703.x.
  11. Pelegrine AA, da Costa CE, Correa ME, Marques JF Jr. Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft. Clin Oral Implants Res 2010;21:535-542. doi: 10.1111/j.1600-0501.2009.01891.x.
  12. Barone A, Aldini NN, Fini M, Giardino R, Calvo Guirado JL, Covani U. Xenograft versus extraction alone for ridge preservation after tooth removal: a clinical and histomorphometric study. J Periodontol 2008;79:1370-1377. doi: 10.1902/jop.2008.070628.
  13. Brownfield LA, Weltman RL. Ridge preservation with or without an osteoinductive allograft: a clinical, radiographic, micro-computed tomography, and histologic study evaluating dimensional changes and new bone formation of the alveolar ridge. J Periodontol 2012;83:581-589. doi: 10.1902/jop.2011.110365.
  14. Camargo PM, Lekovic V, Weinlaender M, Klokkevold PR, Kenney EB, Dimitrijevic B, Nedic M, Jancovic S, Orsini M. Influence of bioactive glass on changes in alveolar process dimensions after exodontia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:581-586. doi: 10.1067/moe.2000.110035.
  15. Festa VM, Addabbo F, Laino L, Femiano F, Rullo R. Porcinederived xenograft combined with a soft cortical membrane versus extraction alone for implant site development: a clinical study in humans. Clin Implant Dent Relat Res 2013;15:707-713. doi: 10.1111/j.1708-8208.2011.00398.x.
  16. Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA, Scheetz JP. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol 2003;74:990-999. doi: 10.1902/jop.2003.74.7.990.
  17. Serino G, Biancu S, Iezzi G, Piattelli A. Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: a clinical and histological study in humans. Clin Oral Implants Res 2003;14:651-658. doi: 10.1034/j.1600-0501.2003.00970.x.
  18. Ten Heggeler JM, Slot DE, Van der Weijden GA. Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: a systematic review. Clin Oral Implants Res 2011;22:779-788. doi: 10.1111/j.1600-0501.2010.02064.x.
  19. Breine U, Branemark PI. Reconstruction of alveolar jaw bone. An experimental and clinical study of immediate and preformed autologous bone grafts in combination with osseointegrated implants. Scand J Plast Reconstr Surg 1980;14:23-48. https://doi.org/10.3109/02844318009105733
  20. Melcher AH. On the repair potential of periodontal tissues. J Periodontol 1976;47:256-260. doi: 10.1902/jop.1976.47.5.256.
  21. Becker W, Becker BE. Guided tissue regeneration for implants placed into extraction sockets and for implant dehiscences: surgical techniques and case report. Int J Periodontics Restorative Dent 1990;10:376-391.
  22. Becker W, Becker BE, Handelsman M, Ochsenbein C, Albrektsson T. Guided tissue regeneration for implants placed into extraction sockets: a study in dogs. J Periodontol 1991;62:703-709. doi: 10.1902/jop.1991.62.11.703.
  23. Wachtel HC, Langford A, Bernimoulin JP, Reichart P. Guided bone regeneration next to osseointegrated implants in humans. Int J Oral Maxillofac Implants 1991;6:127-135.
  24. Zablotsky M, Meffert R, Caudill R, Evans G. Histological and clinical comparisons of guided tissue regeneration on dehisced hydroxylapatite-coated and titanium endosseous implant surfaces: a pilot study. Int J Oral Maxillofac Implants 1991;6:294-303.
  25. Holtzclaw D, Toscano N, Eisenlohr L, Callan D. The safety of bone allografts used in dentistry: a review. J Am Dent Assoc 2008;139:1192-1199. doi: 10.14219/jada.archive.2008.0334.
  26. Boyce T, Edwards J, Scarborough N. Allograft bone. The influence of processing on safety and performance. Orthop Clin North Am 1999;30:571-581. doi: 10.1016/S0030-5898(05)70110-3.
  27. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL. Regeneration of periodontal tissue: bone replacement grafts. Dent Clin North Am 2010;54:55-71. doi: 10.1016/j.cden.2009.09.003.
  28. Gross JS. Bone grafting materials for dental applications: a practical guide. Compend Contin Educ Dent 1997;18:1013-1018, 1020-1022, 1024.
  29. Baldini N, De Sanctis M, Ferrari M. Deproteinized bovine bone in periodontal and implant surgery. Dent Mater 2011;27:61-70. doi: 10.1016/j.dental.2010.10.017.
  30. Poulias E, Greenwell H, Hill M, Morton D, Vidal R, Shumway B, Peterson TL. Ridge preservation comparing socket allograft alone to socket allograft plus facial overlay xenograft: a clinical and histologic study in humans. J Periodontol 2013;84:1567-1575. doi: 10.1902/jop.2013.120585.
  31. Froum SJ, Wallace SS, Elian N, Cho SC, Tarnow DP. Comparison of mineralized cancellous bone allograft (Puros) and anorganic bovine bone matrix (Bio-Oss) for sinus augmentation: histomorphometry at 26 to 32 weeks after grafting. Int J Periodontics Restorative Dent 2006;26:543-551. doi: 10.11607/prd.00.0717.
  32. Piattelli A, Scarano A, Corigliano M, Piattelli M. Comparison of bone regeneration with the use of mineralized and demineralized freeze-dried bone allografts: a histological and histochemical study in man. Biomaterials 1996;17:1127-1131. doi: 10.1016/S0142-9612(99)00015-0.
  33. Kim SK, Kim SG, Oh JS, Jung JW, Yang SS, Lee SY, Park JS, Lim SC, Jeong MA. Evaluation of bone formation after grafting with cancellous and cortical bone allografts in the treatment of bone defects around implants. Oral Biol Res 2011;35:96-102. https://doi.org/10.21851/obr.35.2.201109.96
  34. Lee KI, Lee JS, Jung HH, Lee HY, Moon SH, Kang KT, Shim YB, Jang JW. Inactivation of enveloped and non-enveloped viruses in the process of chemical treatment and gamma irradiation of bovine-derived grafting materials. Xenotransplantation 2012;19:365-369. doi: 10.1111/xen.12011.
  35. Lee KI, Lee JS, Lee KS, Jung HH, Ahn CM, Kim YS, Shim YB, Jang JW. Mechanical-chemical analyses and sub-chronic systemic toxicity of chemical treated organic bovine bone. Regul Toxicol Pharmacol 2015;73:747-753. doi: 10.1016/j.yrtph.2015.10.027.
  36. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop Relat Res 1986;(205):299-308.
  37. Dohan Ehrenfest DM, Lemo N, Jimbo R, Sammartino G. Selecting a relevant animal model for testing the in vivo effects of Choukroun's platelet-rich fibrin (PRF): rabbit tricks and traps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:413-416. doi: 10.1016/j.tripleo.2010.05.057.
  38. Frame JW. A convenient animal model for testing bone substitute materials. J Oral Surg 1980;38:176-180.
  39. Paknejad M, Rokn AR, Yaghobee S, Moradinejad P, Heidari M, Mehrfard A. Effects of two types of anorganic bovine bone on bone regeneration: a histological and histomorphometric study of rabbit calvaria. J Dent (Tehran) 2014;11:687-695.
  40. Torres J, Tamimi FM, Tresguerres IF, Alkhraisat MH, Khraisat A, Lopez-Cabarcos E, Blanco L. Effect of solely applied platelet-rich plasma on osseous regeneration compared to Bio-Oss: a morphometric and densitometric study on rabbit calvaria. Clin Implant Dent Relat Res 2008;10:106-112. doi: 10.1111/j.1708-8208.2007.00068.x.
  41. Gu SJ, Sohn JY, Lim HC, Um YJ, Jung UW, Kim CS, Lee YK, Choi SH. The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite. J Korean Acad Periodontol 2009;39:321-329. doi: 10.5051/jkape.2009.39.3.321.
  42. Lee DW, Koo KT, Seol YJ, Lee YM, Ku Y, Rhyu IC, Chung CP, Kim TI. Bone regeneration effects of human allogenous bone substitutes: a preliminary study. J Periodontal Implant Sci 2010;40:132-138. doi: 10.5051/jpis.2010.40.3.132.
  43. Ryu HC, Park JB, Kwon YH, Herr Y, Chung JH, Jue SS. Histologic evaluation of the regenerated bone using bone graft materials. J Korean Acad Periodontol 2006;36:289-303. doi: 10.5051/jkape.2006.36.2.289.
  44. Gothi R, Bansal M, Kaushik M, Khattak BP, Sood N, Taneja V. A comparative evaluation of freeze dried bone allograft and decalcified freeze dried bone allograft in the treatment of intrabony defects: a clinical and radiographic study. J Indian Soc Periodontol 2015;19:411-415. doi: 10.4103/0972-124X.154169.
  45. Kim TI, Chung CP, Heo MS, Park YJ, Rhee SH. Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects. J Periodontal Implant Sci 2010;40:220-226. doi: 10.5051/jpis.2010.40.5.220.