Urogenital Tract Infection

The Korean Association of Urogenital Tract Infection and Inflammation (대한요로생식기감염학회)
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Comparison of the Efficacy between the Single-Dose and Three-Day Prophylactic Antibiotic Regimens for the Prevention of Bacterial Infections in Patients with Percutaneous Nephrolithotomy: A Randomized Controlled Study

  • Chae, Han Kyu (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Myong (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shin, Jung Hyun (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Hyung Keun (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2018.08.09
  • Accepted : 2018.09.13
  • Published : 2018.12.31
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Abstract

Purpose: To determine the appropriate regimen of antibiotic prophylaxis for the prevention of bacterial infections in patients receiving percutaneous nephrolithotomy (PCNL). Materials and Methods: Forty patients, who planned to undergo PCNL from October 2015 to August 2017, were assigned randomly into two groups. Patients in the single-dose group (n=20) were administered an intravenous single dose of 2 g ceftriaxone 30 minutes before PCNL, whereas those in the three-days regimen group (n=20) were administered a preoperative intravenous single dose of 2 g ceftriaxone and an additional postoperative oral cefpodoxime proxetil (100 mg twice a day) for three days. The incidences of infectious complications in the two groups, such as pyrexia, systemic inflammatory response syndrome (SIRS), and sepsis, were compared. Results: Fever (axillary temperature >$38.0^{\circ}C$) did not develop in any of the patients in the single-dose group but developed in one patient (5.0%) in the three-day regimen group due to pneumonia (p=0.3). SIRS developed in a total of eight patients (20.0%), four patients from each group. None of the patients in either group developed sepsis after PCNL. Conclusions: The three-day prophylactic antibiotic regimen did not demonstrate better efficacy for the prevention of bacterial infections in patients with PCNL compared to the single-dose prophylactic antibiotic regimen.

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References

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