Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Hyperbaric Oxygen Intervention on Alcohol-Induced Oxidative Stress and Hangover in Hyperbaric Oxygen Chamber

고압산소챔버 중재가 알코올에 의한 산화적 스트레스 및 숙취 해소에 미치는 영향

  • Kwon, Hyeok Chan (Department of Biomedical Engineering, Graduate School, Konyang University) ;
  • Park, Soon Won (Department of Biomedical Engineering, Graduate School, Konyang University) ;
  • Cho, Hyun Jeong (Department of Biomedical Laboratory Science, Konyang University) ;
  • Kang, Ji Hyun (Department of Family Medicine, Konyang University Hospital) ;
  • Lee, Hyun Ju (Department of Physical Therapy, Konyang University) ;
  • Tae, Ki Sik (Department of Biomedical Engineering, Graduate School, Konyang University)
  • 권혁찬 (건양대학교대학원 의료공학과) ;
  • 박순원 (건양대학교대학원 의료공학과) ;
  • 조현정 (건양대학교 임상병리학과) ;
  • 강지현 (건양대학교병원 가정의학과) ;
  • 이현주 (건양대학교 물리치료학과) ;
  • 태기식 (건양대학교대학원 의료공학과)
  • Received : 2018.08.12
  • Accepted : 2018.09.18
  • Published : 2018.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study is to evaluate the reliability and effectiveness of hyperbaric oxygen chamber on alcohol-induced oxidative stress and hangover. In order to evaluate them, 20 healthy adults were tested for blood and hangover stress tests. When an exponential change was examined after 3 interventions (hangover drink, hyperbaric oxygen chamber, and normal chamber as placebo effect) of 1 hour, the heart rate of subjects experiencing a hyperbaric oxygen chamber showed a statistically significant decrease (p < 0.001). The tests of blood alcohol concentration (BAC) as for exquisite hematology analysis, glucose, creatinine, and AST (aspartate aminotransferase) as well as ALT (alanine aminotransferase) used as liver-damage indicator show that the hyperbaric chamber has the effective effect. In the test of lactic acid, CRP (c-reactive protein), cortisol, and creatinine, the hyperbaric chamber shows much more excellent effect than the hangover drink and normal chamber as control groups. Further studies on hyperbaric oxygen chamber intervention including this study could be very helpful for improving lives of both the patients and healthy people.

Keywords

References

  1. C.T. Reinhard, N.J. Planavsky, S.L. Olson, T.W. Lyons, and D.H. Erwin, "Earth's oxygen cycle and the evolution of animal life," Proceedings of the National Academy of Sciences of the United States of America, vol. 32, pp. 8933-8938, 2016.
  2. P.M. Tibbles and J.S. Edelberg, "Hyperbaric-oxygen therapy," New England Journal of Medicine, vol. 334, pp. 1642-1648, 1996. https://doi.org/10.1056/NEJM199606203342506
  3. H.W. Hopf and J. Holm, "Hyperoxia and infection," Best Practice and Research Clinical Anaesthesiology, vol. 22, pp. 553-569, 2008. https://doi.org/10.1016/j.bpa.2008.06.001
  4. H. Andreas, K. Roland, M. Sabine, and W. Urban, "Ture and false concerns about neuroenhancerment, a response to "neu-roenhancers," addiction and research ethics: by D M Shaw", Journal of Medical Ethics, vol. 40, pp. 286-287, 2013.
  5. Y.H. You, H.D. Kim, H. Kim, S.C. Choi, and G.W. Kim, "Clinical applications and contemporary trends of hyperbaric oxygen therapy in Korea," Journal of the Korean Medical Association, vol. 7, pp. 601-606, 2014.
  6. B.H.M. Branco, D.H. Fukuda, L.V. Andreato, J.F.dS. Santos, J.V.D.C. Esteves, and E. Franchini , "The Effects of Hyperbaric Oxygen Therapy on Post-Training Recovery in Jiu-Jitsu Athletes," PLoS ONE, vol. 11, 2016.
  7. H.D. Wilson, J.R. Wilson, and P.N. Fuchs, "Hyperbaric oxygen treatment decreases inflammation and mechanical hypersensitivity in an animal model of inflammatory pain," Brain Research, vol. 1098, pp. 126-128, 2006. https://doi.org/10.1016/j.brainres.2006.04.088
  8. S.H. Kim, M.Y. Young, H.J. Kwon, S.P. Hong, J.H. Choi, and S.Y. Jung "Establishment of Functionality Evaluation System for Hangover Settlement of Health Functional Food," Korea Food and Drug Administration, 2003.
  9. T. Utkan, F. Yildiz, G. Ilbay, S. Ozdemirci, and B.F. Erden, "Blood pressure and vascular reactivity to endothelin-1, phenylephrine, serotonin, KCl and acetylcholine following chronic alcohol consumption in vitro," Fundamental and Clinical Pharmacology, vol. 15, pp. 157-165, 2001. https://doi.org/10.1046/j.1472-8206.2001.00024.x
  10. J.H. Jung, "Effects of 'Morning 7' a natural food ingredient complex, on the hangover," The Sustainability Science Society conference, pp.157-175, 2011.
  11. S.M. Park, B.K. Kang, and T.H Chung, "The Effect of Mildronate on Serum Alcohol Concentration and Hangover Syndrome?," J of Korean Society of food science and nutrition, vol. 27, pp. 168-174, 1998.
  12. K.H. Noh, J.H. Kang, J.J. Kim, J.H. Shin, D.K. Kim, and Y.S. Song, "Effect of Dandelion Juice Supplementation on Alcohol-Induced Oxidative Stress and Hangover in Healthy MaleCollege Students," J of Korean Society of food science and nutrition, vol. 38, pp. 683-693, 2009. https://doi.org/10.3746/jkfn.2009.38.6.683
  13. Z.C. Chung, Y.S. Nam, S.I. Cho, S.H. Yim, J.S. Bang, U.D. Sohn, J.M. Kim, MiS. Kim, K.H. Koo, Z.C. Chung, and J.H. Jeong, "Effects of Curcuma long gum preparation on the Blood Alcohol Level and Hangover," Kor. J. Clin. Pharm., vol. 20, pp. 1-8, 2010.
  14. C.R. Tirapelli, E. Legros, I. Brochu, J.C. Honore, V.L. Lanchote, S.A. Uyemura, A.M. de Olivelira, and P. D'Orleans-Juste, "Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats," British Journal of Pharmacology, vol. 154, pp. 971-981, 2008. https://doi.org/10.1038/bjp.2008.157
  15. M. Malik, A.J. Camm, J.T. Bigger, G. Breithardt, S. Cerutti, R.J. Cohen, P. Coumel, E.L. Fallen, H.L. Kennedy, R.E. Kleiger, F. Lombardi, A. Malliani, A.J. Moss, J.N. Rottman, G. Schmidt, P.J. Schwartz, and D.H. Singer, "Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use," European Heart Journal, vol. 17, pp. 354-381, 1996. https://doi.org/10.1093/oxfordjournals.eurheartj.a014868
  16. E. Schmidt and F.W. Schmidt "Enzymes in Hepatic Disease, In Diagnostic Enzymology," Clinical Biochemistry, vol. 26, pp. 241-251, 1993. https://doi.org/10.1016/0009-9120(93)90123-N
  17. A. Reuben, "Alcohol and the Liver," Current Opinion in Gastroenterology, vol. 22, pp. 263-271, 2006.
  18. D. Kerr, I.A. Macdonald, S.R. Heller, and R.B. Tattersall, "Alcohol Causes Hypoglycaemic Unawareness in Healthy Volunteers and Patients with Type 1(insulin-dependent) Diabetes," Diabetologia, vol. 33, pp. 216-221, 1990. https://doi.org/10.1007/BF00404799
  19. B.C. Turner, E. Jenkins, D. Kerr, R.S. Sherwin, and D.A. Cavan, "The Effect of Evening Alcohol Consumption on Next-morning Glucose Control in Type 1 Diabetes," Diabetes Care, vol. 16, pp. 1888-1893, 2001.
  20. C.J. Glueck, E. Hogg, C. Allen, and P.S. Gartside, "Effects of Alcohol Ingestion on Lipids and Lipoproteins in Normal Men: Isocaloric Metabolic Studies," The American Journal of Clinical Nutrition, vol. 33, pp. 2287-2293, 1980. https://doi.org/10.1093/ajcn/33.11.2287
  21. M. Oscar-Berman and K. Marinkovic, "Alcoholism and the Brain: an Overview," Alcohol Research and Health, vol. 27, pp. 125-133, 2003.
  22. H.D. Wilson, J.R. Wilson, and P.N. Fuchs, "Relationship of Early Life Stress and Psychological Functioning to Adult CReactive Protein in the Coronary Artery Risk Development in Young Adults Study," Brain Research, vol. 1098, pp. 126-128, 2006. https://doi.org/10.1016/j.brainres.2006.04.088
  23. W.R. Lovallo, S.L, Dickensheets, D.A. Myers, T.L. Thomas, and S.J. Nixon, "Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men," Alcoholism: Clinical and Experimental Research, vol. 24, pp. 651-658, 2000. https://doi.org/10.1111/j.1530-0277.2000.tb02036.x
  24. E. Savdie, G.M. Grosslight, and M.A. Adena, "Relation of Alcohol and Cigarette Consumption to Blood Pressure and Serum Creatinine Levels," J of Chronic Diseases, vol. 37, pp, 617-623, 1984. https://doi.org/10.1016/0021-9681(84)90111-5