Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
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Long-Term Survival and Tumor Recurrence in Patients with Superficial Esophageal Cancer after Complete Non-Curative Endoscopic Resection: A Single-Center Case Series

  • Lee, Ji Wan (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Cho, Charles J. (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Do Hoon (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Ahn, Ji Yong (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Lee, Jeong Hoon (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi, Kee Don (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Song, Ho June (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Park, Sook Ryun (Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Lee, Hyun Joo (Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Yong Hee (Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Lee, Gin Hyug (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Jung, Hwoon-Yong (Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Sung-Bae (Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Jong Hoon (Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Park, Seung-Il (Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center)
  • Received : 2018.01.15
  • Accepted : 2018.04.25
  • Published : 2018.09.30
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Abstract

Background/Aims: To report the long-term survival and tumor recurrence outcomes in patients with superficial esophageal cancer (SEC) after complete non-curative endoscopic resection (ER). Methods: We retrieved ER data for 24 patients with non-curatively resected SEC. Non-curative resection was defined as the presence of submucosal and/or lymphovascular invasion on ER pathology. Relevant clinical and tumor-specific parameters were reviewed. Results: The mean age of the 24 study patients was $66.3{\pm}8.3years$. Ten patients were closely followed up without treatment, while 14 received additional treatment. During a mean follow-up of $59.0{\pm}33.2months$, the 3- and 5-year survival rates of all cases were 90.7% and 77.6%, respectively. The 5-year overall survival rates were 72.9% in the close observation group and 82.1% in the additional treatment group (p=0.958). The 5-year cumulative incidences of all cases of recurrence (25.0% vs. 43.3%, p=0.388), primary EC recurrence (10.0% vs. 16.4%, p=0.558), and metachronous EC recurrence (16.7% vs. 26.7%, p=0.667) were similar between the two groups. Conclusions: Patients with non-curatively resected SEC showed good long-term survival outcomes. Given the similar oncologic outcomes, close observation may be an option with appropriate caution taken for patients who are medically unfit to receive additional therapy.

Keywords

References

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Cited by

  1. Non-Curative Endoscopic Resection for Superficial Esophageal Cancer vol.51, pp.5, 2018, https://doi.org/10.5946/ce.2018.138
  2. Close Observation versus Additional Surgery after Noncurative Endoscopic Resection of Esophageal Squamous Cell Carcinoma vol.38, pp.3, 2018, https://doi.org/10.1159/000515717