DOI QR코드

DOI QR Code

Praziquantel Treatment of Eosinophilic Gastritis Suspected to Be Due to Cerebral Sparganosis

뇌 스파르가눔증으로 인한 호산구성 위염 환자에서의 프라지콴텔 치료

  • Lee, Sang-Hoon (Department of Internal Medicine, Kangwon National University School of Medicine) ;
  • Nam, Seung-Joo (Department of Internal Medicine, Kangwon National University School of Medicine) ;
  • Lee, Sung Joon (Department of Internal Medicine, Kangwon National University School of Medicine) ;
  • Kang, Chang Don (Department of Internal Medicine, Kangwon National University School of Medicine) ;
  • Choi, Dae Hee (Department of Internal Medicine, Kangwon National University School of Medicine) ;
  • Choi, Jang Won (Department of Internal Medicine, Kangwon National University School of Medicine) ;
  • Lee, SeungKoo (Department of Anatomic Pathology, Kangwon National University School of Medicine)
  • 이상훈 (강원대학교 의학전문대학원 내과학교실) ;
  • 남승주 (강원대학교 의학전문대학원 내과학교실) ;
  • 이성준 (강원대학교 의학전문대학원 내과학교실) ;
  • 강창돈 (강원대학교 의학전문대학원 내과학교실) ;
  • 최대희 (강원대학교 의학전문대학원 내과학교실) ;
  • 최장원 (강원대학교 의학전문대학원 내과학교실) ;
  • 이승구 (강원대학교 의학전문대학원 해부병리학교실)
  • Received : 2016.04.04
  • Accepted : 2017.09.01
  • Published : 2018.10.01

Abstract

Eosinophilic gastritis is characterized by eosinophilic infiltration of the gastrointestinal tract, which is associated with abdominal pain, diarrhea, nausea, and vomiting. The possible etiologies of secondary eosinophilic gastritis, including drug reactions, parasitic infestation, and malignancy, must be evaluated. Herein we report the case of a 65-year-old North Korean defector who presented with nausea and vomiting for 1 year. Secondary (reactive) eosinophilic gastritis caused by cerebral sparganosis was suspected after a workup that included brain magnetic resonance imaging, cerebrospinal fluid tapping, and gastric mucosal biopsy. The patient showed dramatic clinical improvement with high-dose praziquantel treatment. Even though secondary (reactive) eosinophilic gastritis caused by parasites is very rare, this case shows the importance of considering parasitic infection in eosinophilic gastritis.

저자들은 최근 구역과 구토로 내원한 65세 남자에서 위내시경을 통하여 위체부에 다발성 홍반을 발견하였고, 조직 검사 결과 다수의 호산구 침윤을 확인하였다. 또한 생식을 한 과거력을 바탕으로 혈청과 뇌척수액 검사를 통한 기생충 검사 그리고 뇌 자기공명영상을 시행하여 뇌 스파르가눔증을 의심하였다. 뇌 스파르가눔에 대한 수술적 치료는 시행하지 못하였으나 프라지콴텔을 투여하여 소화기 증상 및 신경학적 증상이 호전되었다. 호산구성 위염의 치료를 위해서는 기생충 감염, 약물, 알레르기 질환 등 이차성 호산구성 위염의 원인을 배제하는 것이 중요하며, 특히 뱀과 개구리를 생식하는 우리나라에서는 병력 청취 및 검사를 통하여 기생충 감염증을 고려하는 것이 필요할 것으로 사료된다.

Keywords

References

  1. Valent P, Klion AD, Horny HP, et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol 2012;130:607-612. https://doi.org/10.1016/j.jaci.2012.02.019
  2. Nayak VH, Engin NY, Burns JJ, Ameta P. Hypereosinophilic syndrome with eosinophilic gastritis. Glob Pediatr Health 2017;4:2333794X17705239.
  3. Muraoka A, Suehiro I, Fujii M, et al. Acute gastric anisakiasis: 28 cases during the last 10 years. Dig Dis Sci 1996;41:2362-2365. https://doi.org/10.1007/BF02100128
  4. Rivasi F, Pampiglione S, Boldorini R, Cardinale L. Histopathology of gastric and duodenal strongyloides stercoralis locations in fifteen immunocompromised subjects. Arch Pathol Lab Med 2006;130:1792-1798.
  5. Oncu K, Yazgan Y, Kaplan M, et al. An extremely uncommon case of parasitic infection presenting as eosinophilic ascites in a young patient. Case Rep Gastroenterol 2011;5:139-143. https://doi.org/10.1159/000326927
  6. Lee JH, Kim GH, Kim SM, et al. A case of sparganosis that presented as a recurrent pericardial effusion. Korean Circ J 2011;41:38-42. https://doi.org/10.4070/kcj.2011.41.1.38
  7. Choi MH, Kim HT, Kwak TY, et al. Praziquantel treatment of an eosinophilic pleuritis patient suspected to be due to sparganum infection. Infect Chemother 2012;44:522-525. https://doi.org/10.3947/ic.2012.44.6.522
  8. Park HY, Lee SU, Kim SH, et al. Epidemiological significance of sero-positive inhabitants against sparganum in Kangwon-do, Korea. Yonsei Med J 2001;42:371-374. https://doi.org/10.3349/ymj.2001.42.4.371
  9. Lee SH, Kim MN, Back BY, Choi JY, Kim TH, Hwang YS. Analysis of parasite-specific-antibody positive patients for clonorchis sinensis, paragonimus westermani, cysticercus and sparganum using ELISA. Korean J Lab Med 2003;23:126-131.
  10. Gonzenbach RR, Kong Y, Beck B, Buck A, Weller M, Semmler A. High-dose praziquantel therapy for cerebral sparganosis. J Neurol 2013;260:1423-1425. https://doi.org/10.1007/s00415-013-6901-7