The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Takayasu Arteritis: Update on Monitoring of Disease Activity and Management

타카야수동맥염의 최신 진료 및 치료 동향

  • Park, Eun Hye (Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Lee, Eun Young (Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Song, Yeong Wook (Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine)
  • 박은혜 (서울대학교 의과대학 내과학교실 류마티스내과) ;
  • 이은영 (서울대학교 의과대학 내과학교실 류마티스내과) ;
  • 송영욱 (서울대학교 의과대학 내과학교실 류마티스내과)
  • Published : 2018.10.01
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Abstract

Takayasu arteritis (TAK) is a chronic inflammatory disease characterized by granulomatous vasculitis of the aorta and its major branches. The rarity of the disease along with its heterogeneous clinical presentation typically lead to late diagnosis and delayed treatment. Furthermore, clinical and serological indices for monitoring disease activity are suboptimal, with no definitive evidence supporting therapeutic approaches in TAK. Nevertheless, there have been recent advances in disease assessment with new scoring systems (Indian Takayasu Arteritis Score), biomarkers including pentraxin 3 and soluble human leukocyte antigen-E, and imaging modalities such as $^{18}F$-fluorodeoxyglucose-positron emission tomography. Most of the new information for management of TAK has come from increasing experience with biological agents, such as tumor necrosis factor inhibitors and tocilizumab, used in the treatment of resistant TAK. A number of potential new therapeutic targets that may be useful for the treatment of TAK have been reported, and randomized controlled trials are needed to establish optimal therapeutic approaches.

Keywords

References

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