The Korean Journal of Gastroenterology (대한소화기학회지)

The Korean Society of Gastroenterology (대한소화기학회)
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Female Gender is a Poor Predictive Factor of Functional Dyspepsia Resolution after Helicobacter pylori Eradication: A Prospective, Multi-center Korean Trial

기능성 소화불량증 환자에서 헬리코박터 파일로리 제균 치료 효과 및 관련 요인: 국내 전향적, 다기관 연구

  • Kim, Sung Eun (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Kim, Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Park, Seon Mee (Department of Internal Medicine, College of Medicine, Chungbuk National University) ;
  • Kim, Won Hee (Digestive Disease Center, CHA Bundang Medical Center, CHA University) ;
  • Baik, Gwang Ho (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Jo, Yunju (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Park, Kyung Sik (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Lee, Ju Yup (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Shim, Ki-Nam (Department of Internal Medicine, Ewha Womans University College of Medicine) ;
  • Kim, Gwang Ha (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Lee, Bong Eun (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Hong, Su Jin (Department of Internal Medicine and Research Institute, Soonchunhyang University College of Medicine) ;
  • Park, Seon-Young (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Choi, Suck Chei (Department of Internal Medicine, Wonkwang University School of Medicine) ;
  • Oh, Jung Hwan (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hyun Jin (Department of Internal Medicine, Gyeongsang National University School of Medicine)
  • 김성은 (고신대학교 의과대학 내과학교실) ;
  • 김나영 (분당서울대학교병원 내과) ;
  • 박선미 (충북대학교 의과대학 내과학교실) ;
  • 김원희 (차의과학대학교 분당차병원 소화기센터) ;
  • 백광호 (한림대학교 의과대학 내과학교실) ;
  • 조윤주 (을지대학교 의과대학 내과학교실) ;
  • 박경식 (계명대학교 의과대학 내과학교실) ;
  • 이주엽 (계명대학교 의과대학 내과학교실) ;
  • 심기남 (이화여자대학교 의과대학 내과학교실) ;
  • 김광하 (부산대학교 의학전문대학원 내과학교실 및 부산대학교병원 의생명연구원) ;
  • 이봉은 (부산대학교 의학전문대학원 내과학교실 및 부산대학교병원 의생명연구원) ;
  • 홍수진 (순천향대학교 의과대학 내과학교실 소화기병연구소) ;
  • 박선영 (전남대학교 의과대학 내과학교실) ;
  • 최석채 (원광대학교 의과대학 내과학교실) ;
  • 오정환 (가톨릭대학교 의과대학 내과학교실) ;
  • 김현진 (경상대학교 의학전문대학원 내과학교실)
  • Received : 2018.09.02
  • Accepted : 2018.11.07
  • Published : 2018.12.25
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Abstract

Background/Aims: The predictive factors of functional dyspepsia (FD) remain controversial. Therefore, we sought to investigate symptom responses in FD patients after Helicobacter pylori (H. pylori) eradication and used predictive factor analysis to identify significant factors of FD resolution at one-year after commencing eradication therapy. Methods: This prospective, multi-center clinical trial was performed on 65 FD patients that met Rome III criteria and had H. pylori infection. Symptom responses and factors that predicted poor response were determined by analysis one year after commencing H. pylori eradication therapy. Results: A total of 63 patients completed the one-year follow-up. When an eradication success group (n=60) and an eradication failure group (n=3) were compared with respect to FD response rate at one year, results were as follows; complete response 73.3% and 0.0%, satisfactory response 1.7% and 0.0%, partial response 10.0% and 33.3%, and refractory response 15.0% and 66.7%, respectively (p=0.013). Univariate analysis showed persistent H. pylori infection (p=0.021), female gender (p=0.025), and medication for FD during the study period (p=0.013) were associated with poor FD response at one year. However, age, smoking, alcohol consumption, and underlying disease were not found to affect response. Finally, multivariate analysis showed that female gender (OR, 4.70; 95% CI, 1.17-18.88) was the sole independent risk factor of poor FD response at one year after commencing H. pylori eradication therapy. Conclusions: Female gender was found to predict poor response in FD patients despite H. pylori eradication. Furthermore, successful H. pylori eradication appears to be associated with FD improvement, but the number of non-eradicated patients was too small to conclude.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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